Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Akiyoshi Shimaya"'
Publikováno v:
In Journal of Pharmacological Sciences 2006 101(4):311-317
Autor:
Akiyoshi Shimaya, Masayuki Shibasaki, Yasuharu Urano, Takeyuki Nagashima, Hirotsugu Tanaka, Teruhiko Shimokawa
Publikováno v:
European Journal of Pharmacology. 645:185-191
Recent evidence suggests that the forkhead transcription factor Foxo1 plays an important role in the regulation of glucose and triglyceride metabolism at the gene transcription level for glucose-6 phosphatase (G6Pase), phosphoenolpyruvate carboxykina
Autor:
Masanori Yokono, Akiyoshi Shimaya, Masayuki Shibasaki, Shigeru Yoshida, Eiji Kurosaki, Ryosuke Nakano, Tatsuya Maruyama
Publikováno v:
Biochemical Pharmacology. 72:42-52
Peroxisome proliferator-activated receptor gamma (PPARgamma) has been reported to play an important role to regulate adiposity and insulin sensitivity. It is not clear whether antagonism of PPARgamma using a synthetic ligand has significant effects o
Publikováno v:
Journal of Pharmacological Sciences, Vol 101, Iss 4, Pp 311-317 (2006)
The novel hypoglycemic agent YM440 ((Z)-1,4-bis{4-[(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)methyl] phenoxy}but-2-ene) is a ligand of the peroxisome proliferator-activated receptor (PPAR) γ. YM440 has unique pharmacological profiles both in vitro and in
Publikováno v:
Journal of Biological Chemistry. 279:55277-55282
Although a number of studies and approaches have indicated that activation of the Ser/Thr kinase called Akt/protein kinase B is critical for the insulin-stimulated increase of glucose uptake in adipocytes, other studies have indicated that this enzym
Autor:
Eiji Kurosaki, Masayuki Shibasaki, Akiyoshi Shimaya, Kazuhiro Momose, Hisataka Shikama, Takayuki Suzuki, Ryosuke Nakano
Publikováno v:
European Journal of Pharmacology. 468:151-158
Using a glucose clamp, we had shown that YM440, ( Z )-1,4-bis{4-[(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)methyl]phenoxy}but-2-ene, reduced the increased hepatic glucose output in obese Zucker rats. We further examined effects of YM440 on 14 C-incorporati
Autor:
Eiji Kurosaki, Akiyoshi Shimaya, Ryosuke Nakano, Masayuki Shibasaki, Hisataka Shikama, Kazuhiro Momose, Takayuki Suzuki
Publikováno v:
Japanese Journal of Pharmacology. 89:274-281
We studied the role of hepatic glycogenesis in glucose intolerance after glucose loading in obese Zucker rats and the effects of YM440 ((Z)-1,4-bis{4-[(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)methyl]phen-oxy}but-2-ene) on it. Lean and obese Zucker rats we
Autor:
Masayuki Shibasaki, Hideaki Minoura, Hirotsugu Tanaka, Akiyoshi Shimaya, Teruhiko Shimokawa, Kenji Negoro, Shigeru Yoshida
Publikováno v:
Life sciences. 94(2)
Aims GPR40 is a free fatty acid receptor that regulates glucose-dependent insulin secretion at pancreatic β-cells and glucagon-like peptide-1 (GLP-1), one of the major incretins, secretion at the endocrine cells of the gastrointestinal tract. We inv
Autor:
Teruhiko Shimokawa, Takeyuki Nagashima, Riyo Maruki, Yasuharu Urano, Akiyoshi Shimaya, Masayuki Shibasaki, Hirotsugu Tanaka, Nobuharu Shigematsu
Publikováno v:
Molecular pharmacology. 78(5)
Excessive hepatic glucose production through the gluconeogenesis pathway is partially responsible for the elevated glucose levels observed in patients with type 2 diabetes mellitus (T2DM). The forkhead transcription factor forkhead box O1 (Foxo1) pla
Publikováno v:
Chemical and Pharmaceutical Bulletin. 40:2783-2786
At least three types of vanadate-insensitive membranous ATPase were identified on rat liver lysosomes: bafilomycin A1-sensitive Mg(2+)-ATPase (H(+)-ATPase), N-ethylmaleimide (NEM)-sensitive but bafilomycin A1-insensitive Mg(2+)-ATPase (ATPase I), and