Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Akiyoshi Komuro"'
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/57ada5f9d3ae49d7b35cf4d41f18533f
Publikováno v:
Cell Death and Disease, Vol 15, Iss 2, Pp 1-13 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is considered one of the most lethal forms of cancer. Although in the last decade, an increase in 5-year patient survival has been observed, the mortality rate remains high. As a first-line treatment f
Externí odkaz:
https://doaj.org/article/e52b92cb32444e7285c5deb3aaca81cd
Autor:
Ryo Tanabe, Kohei Miyazono, Tomoki Todo, Nobuhito Saito, Caname Iwata, Akiyoshi Komuro, Satoshi Sakai, Erna Raja, Daizo Koinuma, Masato Morikawa, Bengt Westermark, Carl‐Henrik Heldin
Publikováno v:
Molecular Oncology, Vol 16, Iss 1, Pp 269-288 (2022)
Glioma‐initiating cells (GICs), a major source of glioblastoma recurrence, are characterized by the expression of neural stem cell markers and the ability to grow by forming nonadherent spheres under serum‐free conditions. Bone morphogenetic prot
Externí odkaz:
https://doaj.org/article/f4c4a73f1b084baab8b336259bb1ce03
KDM4B promotes acute myeloid leukemia associated with AML1‐ETO by regulating chromatin accessibility
Autor:
Takeshi Ueda, Akinori Kanai, Akiyoshi Komuro, Hisayuki Amano, Kazushige Ota, Masahiko Honda, Masahito Kawazu, Hitoshi Okada
Publikováno v:
FASEB BioAdvances, Vol 3, Iss 12, Pp 1020-1033 (2021)
Abstract Epigenetic alterations of chromatin structure affect chromatin accessibility and collaborate with genetic alterations in the development of cancer. Lysine demethylase 4B (KDM4B) has been identified as a JmjC domain‐containing epigenetic mo
Externí odkaz:
https://doaj.org/article/5926bec7943c4cc888c811f78ca73aa2
Autor:
Kazushige Ota, Akiyoshi Komuro, Hisayuki Amano, Akinori Kanai, Kai Ge, Takeshi Ueda, Hitoshi Okada
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Abstract Obesity increases the risk of metabolic disorders like diabetes mellitus and dyslipidemia. However, how metabolic status is sensed and regulates cellular behavior is unclear. Utx is an H3K27 demethylase that influences adipocyte function in
Externí odkaz:
https://doaj.org/article/61739a8843d14250a281079be978bd08
Autor:
Naohiro Oka, Akiyoshi Komuro, Hisayuki Amano, Suman Dash, Masahiko Honda, Kazushige Ota, Shunji Nishimura, Takeshi Ueda, Masao Akagi, Hitoshi Okada
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 4, Pp n/a-n/a (2020)
Abstract Osteosarcoma (OS) is the most common malignant bone tumor and a leading cause of cancer‐related deaths in children and adolescents. Current standard treatments for OS are a combination of preoperative chemotherapy, surgical resection, and
Externí odkaz:
https://doaj.org/article/e023b6ec52b74759824c06d2cf75671c
Autor:
Kazushige Ota, Kit I Tong, Kouichiro Goto, Shuta Tomida, Akiyoshi Komuro, Zhong Wang, Kazuto Nishio, Hitoshi Okada
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173713 (2017)
Understanding the molecular mechanisms that drive adipogenesis is important in developing new treatments for obesity and diabetes. Epigenetic regulations determine the capacity of adipogenesis. In this study, we examined the role of a histone H3 lysi
Externí odkaz:
https://doaj.org/article/e50c2244787e43a59cf6b130d050148b
Autor:
Suman Dash, Takeshi Ueda, Akiyoshi Komuro, Hisayuki Amano, Masahiko Honda, Masahito Kawazu, Hitoshi Okada
Publikováno v:
Molecular Cancer Research. 21:444-457
Pancreatic ductal adenocarcinoma (PDAC) is one of the most life-threatening malignancies. Although the deoxycytidine analog gemcitabine has been used as the first-line treatment for PDAC, the primary clinical challenge arises because of an eventual a
Autor:
Hitoshi Okada, Masahito Kawazu, Masahiko Honda, Hisayuki Amano, Akiyoshi Komuro, Takeshi Ueda, Suman Dash
Supplementary Table 1.sgRNA barcode PCR primers. PCR, polymerase chain reactionSupplementary Table 2.Pool A and Pool B log2 fold change of >10 upregulated sgRNA oligo sequencesSupplementary Table 3.Primer sequences used for RT-qPCR and CRISPR/Cas9 de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10737b7836c4600c92b49cd931f4872f
https://doi.org/10.1158/1541-7786.22725287.v1
https://doi.org/10.1158/1541-7786.22725287.v1
Autor:
Hitoshi Okada, Masahito Kawazu, Masahiko Honda, Hisayuki Amano, Akiyoshi Komuro, Takeshi Ueda, Suman Dash
Pancreatic ductal adenocarcinoma (PDAC) is one of the most life-threatening malignancies. Although the deoxycytidine analog gemcitabine has been used as the first-line treatment for PDAC, the primary clinical challenge arises because of an eventual a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e5d622406d6e43d5be8e0a30d94f59
https://doi.org/10.1158/1541-7786.c.6545925.v2
https://doi.org/10.1158/1541-7786.c.6545925.v2