Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Akiyo Shigematsu"'
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 32:149-162
A marked difference in the healing process of the inferior vena cava in rats following a stab with a 17-G (1.48 mm phi) ultrahard zirconium ceramic (Zr) needle and with a common stainless steel (St) needle (also 1.48 mm phi was observed. This was inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9839a20f1b734d33a63f5a2e7a4d902
https://doi.org/10.1007/bf03190477
https://doi.org/10.1007/bf03190477
Autor:
Dong Hyuk Shin, Yasuhiko Hatori, Kyong Bae Park, Cheol Kwak, Junko Nishigaki, Seung Kyoo Seong, Jei Man Ryu, Sang Eun Lee, Eun Jeong Bae, Akiyo Shigematsu
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 32:910-917
The objective of this study was to determine the fate of the 166Ho-chitosan complex (DW-166HC) in rats by examining its absorption, distribution and excretion after administration into the prostate. About 100 μCi of DW-166HC [containing 0.1875 mg of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::334540785dac7a269f04f8a958a7887a
https://doi.org/10.1007/s00259-005-1792-1
https://doi.org/10.1007/s00259-005-1792-1
Autor:
Yasuyuki Debori, Hisamichi Yamabayashi, Hiroyuki Kuroiwa, Norihiro Takeuchi, Noriko Higashi, Yuichi Sato, Akiyo Shigematsu, Naoshi Kawai, Awazu Shoji, Joji Yui, Yuko Hamai, Akiko Hatori, Takeo Yamamoto
Publikováno v:
Regulatory Toxicology and Pharmacology. 40:207-218
A synchronous evaluation was performed, using a quick in vivo [2- 14 C]thymidine labeling method, of the toxico- and pharmaco-dynamics of a given dose of yttrium-90 ( 90 Y) at a given time after injection to nude BALB/c mice loaded with 10 7 HuO9 cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f8fbc4baca3d69ff0f791935f6d87c
https://doi.org/10.1016/j.yrtph.2004.07.012
https://doi.org/10.1016/j.yrtph.2004.07.012
Autor:
Hiroyuki Fukuda, Akiyo Shigematsu, Naomi Motoji, Mitsunobu Okuyama, Takaho Watayo, Masaaki Ebara, Hiromitsu Saisho, Masaharu Yoshikawa, Nobuyuki Sugiura, Ryo Shimizu
Publikováno v:
Carcinogenesis. 23:2019-2023
The aim of this study was to determine the metabolizing activities in the liver of patients with hepatocellular carcinoma (HCC). Thin-layer chromatography autoradioluminography was used to measure metabolizing activities. Succinate-producing activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a714c8cd4fa67d1ef45c7b1897942686
https://doi.org/10.1093/carcin/23.12.2019
https://doi.org/10.1093/carcin/23.12.2019
Publikováno v:
Experimental and Molecular Pathology. 69:119-143
In an attempt to improve liver slice culture for in vitro tests of newly developed drugs, we found that a relatively thick 2-mm slice was much more viable, long-lived, and metabolically functional than the conventionally used 300-μm-thick slices. Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a22691210f95ae7c4d411330c02f6b02
https://doi.org/10.1006/exmp.2000.2325
https://doi.org/10.1006/exmp.2000.2325
Autor:
Naomi Motoji, Yuko Hamai, Michiaki Aihara, Yasuhiko Hatori, Sadahiko Iwai, Kenji Miura, Akiyo Shigematsu, Masashi Ogawa, Masayasu Asaumi
Publikováno v:
Experimental and Molecular Pathology. 67:75-90
To assess recent improvements in quantitative whole-body autoradioluminography (QWBA), the entire QWBA procedure was divided into five processes. Each process was then investigated carefully to determine whether there were any problems in defining a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71125e7340f7472145bd39ef71b429e3
https://doi.org/10.1006/exmp.1999.2272
https://doi.org/10.1006/exmp.1999.2272
Autor:
Noriaki Tatsuta, Naomi Suzuki, Keizo Koya, Takae Mochizuki, Naomi Motoji, Masayuki Kawakami, Lan Bo Chen, Akiyo Shigematsu, Tadao Shishido, Hiroyuki Kuroiwa
Publikováno v:
Cancer Chemotherapy and Pharmacology. 43:295-301
MKT-077 (1-ethyl-2-[[3-ethyl-5-(3-methylbenzothiazolin-2-yliden)]-4- oxothiazolidin-2-ylidenemethyl] pyridinium chloride), a novel rhodacyanine dye in phase I/II clinical trials, may provide a new approach to cancer therapy based on the accumulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c3bb8746ada93f3d77f655600bdf8c
https://doi.org/10.1007/s002800050898
https://doi.org/10.1007/s002800050898
Autor:
Yukio Kato, Yuki Izumi, Yuichi Sugiyama, Akiyo Shigematsu, Hiroshi Kiwada, Tatsuro Irimura, Kazuhiko Shirota, Naomi Motoji, Hideyoshi Harashima, Naomi Mizuno
Publikováno v:
Journal of Hepatology. 28:878-885
Background/Aims/Methods: The distribution characteristics of a human colon carcinoma cell line, KM12-HX cells, were examined. After intraportal vein (i.p.v.) or intravenous (i.v.) injection into rats, almost all the injected tumor cells are distribut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b44ba6f00855ef76c551a060322fd441
https://doi.org/10.1016/s0168-8278(98)80239-0
https://doi.org/10.1016/s0168-8278(98)80239-0
Autor:
Akiyo Shigematsu, Akira Narita, Sadami Shibabe, Masahiko Kumakura, Masayuki Ito, Toshio Nanbo
Publikováno v:
Journal of Reproduction and Development. 44:205-208
Immature epidermis, dermis and subcutaneous tissues were histologically observed in the fetal skin of rats on day 17 of pregnancy. The tissues had become thicker in the fetal skin by day 19, and formed the basement membrane. The strata corneum and gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c99b988186f40dd545df29cbf3e5cfc
https://doi.org/10.1262/jrd.44.205
https://doi.org/10.1262/jrd.44.205
Publikováno v:
Regulatory Toxicology and Pharmacology. 22:122-142
Autoradiographic data of distinctive tissue distributions of 14 C atoms obtained by labeling at two different positions of a new drug suggest the metabolic fates of each labeled compound in experimental animals. A more accurate determination of blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd3fd7b24e83191ff399b09ae451331
https://doi.org/10.1006/rtph.1995.1078
https://doi.org/10.1006/rtph.1995.1078