Zobrazeno 1 - 10
of 220
pro vyhledávání: '"Akiva, Mintz"'
Autor:
Masih Tazhibi, Nicholas McQuillan, Hong-Jian Wei, Matthew Gallitto, Ethan Bendau, Andrea Webster Carrion, Xander Berg, Danae Kokossis, Xu Zhang, Zhiguo Zhang, Chia-Ing Jan, Akiva Mintz, Robyn D. Gartrell, Hasan R. Syed, Adriana Fonseca, Jovana Pavisic, Luca Szalontay, Elisa E. Konofagou, Stergios Zacharoulis, Cheng-Chia Wu
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background Diffuse midline glioma (DMG) is a pediatric tumor with dismal prognosis. Systemic strategies have been unsuccessful and radiotherapy (RT) remains the standard-of-care. A central impediment to treatment is the blood–brain barrier
Externí odkaz:
https://doaj.org/article/159f8aa414984404a35643a5ecfeb319
Autor:
Naresh Damuka, Miranda E. Orr, Avinash H. Bansode, Ivan Krizan, Mack Miller, Jillian Lee, Shannon L. Macauley, Christopher T. Whitlow, Akiva Mintz, Suzanne Craft, Kiran Kumar Solingapuram Sai
Publikováno v:
EJNMMI Research, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Background Microtubules (MTs) are critical for cell structure, function, and survival. MT instability may contribute to Alzheimer’s disease (AD) pathogenesis as evidenced by persistent negative regulation (phosphorylation) of the neuronal
Externí odkaz:
https://doaj.org/article/55965fc1ff5845699b0af3989855e83d
Autor:
Pedro A. C. Costa, Walison N. Silva, Pedro H. D. M. Prazeres, Caroline C. Picoli, Gabriela D. A. Guardia, Alinne C. Costa, Mariana A. Oliveira, Pedro P. G. Guimarães, Ricardo Gonçalves, Mauro C. X. Pinto, Jaime H. Amorim, Vasco A. C. Azevedo, Rodrigo R. Resende, Remo C. Russo, Thiago M. Cunha, Pedro A. F. Galante, Akiva Mintz, Alexander Birbrair
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-41 (2021)
Abstract Sensory neurons have recently emerged as components of the tumor microenvironment. Nevertheless, whether sensory neuronal activity is important for tumor progression remains unknown. Here we used Designer Receptors Exclusively Activated by a
Externí odkaz:
https://doaj.org/article/3bc21826b70242beab95f440ca474ea2
[18F]KS1, a novel ascorbate-based ligand images ROS in tumor models of rodents and nonhuman primates
Autor:
Naresh Damuka, Nagaraju Bashetti, Akiva Mintz, Avinash H. Bansode, Mack Miller, Ivan Krizan, Cristina Furdui, Bhuvanachandra Bhoopal, Krishna Kumar Gollapelli, JV Shanmukha Kumar, Gagan Deep, Greg Dugan, Mark Cline, Kiran Kumar Solingapuram Sai
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 156, Iss , Pp 113937- (2022)
Over production of reactive oxygen species (ROS) caused by altered redox regulation of signaling pathways is common in many types of cancers. While PET imaging is recognized as the standard tool for cancer imaging, there are no clinically-approved PE
Externí odkaz:
https://doaj.org/article/9037725abf044ab3a4b3c63fe778673b
Autor:
Brittanie Partridge, Allison Eardley, Brianna E. Morales, Sabrina N. Campelo, Melvin F. Lorenzo, Jason N. Mehta, Yukitaka Kani, Josefa K. Garcia Mora, Etse-Oghena Y. Campbell, Christopher B. Arena, Simon Platt, Akiva Mintz, Richard L. Shinn, Christopher G. Rylander, Waldemar Debinski, Rafael V. Davalos, John H. Rossmeisl
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
The blood-brain barrier (BBB) presents a formidable obstacle to the effective delivery of systemically administered pharmacological agents to the brain, with ~5% of candidate drugs capable of effectively penetrating the BBB. A variety of biomaterials
Externí odkaz:
https://doaj.org/article/4dd41ae5e6864af2948892771284a5a7
Autor:
Caroline C. Picoli, Alinne C. Costa, Beatriz G.S. Rocha, Walison N. Silva, Gabryella S.P. Santos, Pedro H.D.M. Prazeres, Pedro A.C. Costa, Anderson Oropeza, Rodrigo A. daSilva, Vasco A.C. Azevedo, Rodrigo R. Resende, Thiago M. Cunha, Akiva Mintz, Alexander Birbrair
Publikováno v:
Stem Cells Translational Medicine, Vol 10, Iss 3, Pp 346-356 (2021)
Abstract Niches are specialized tissue microenvironments that control stem cells functioning. The bone marrow mesenchymal stem cell niche defines a location within the marrow in which mesenchymal stem cells are retained and produce new cells througho
Externí odkaz:
https://doaj.org/article/09633ec821a04618ae4e1e842efa5018
Autor:
Avinash H. Bansode, Bhuvanachandra Bhoopal, Krishna Kumar Gollapelli, Naresh Damuka, Ivan Krizan, Mack Miller, Suzanne Craft, Akiva Mintz, Kiran Kumar Solingapuram Sai
Publikováno v:
Pharmaceuticals, Vol 16, Iss 4, p 495 (2023)
Impairment and/or destabilization of neuronal microtubules (MTs) resulting from hyper-phosphorylation of the tau proteins is implicated in many pathologies, including Alzheimer’s disease (AD), Parkinson’s disease and other neurological disorders.
Externí odkaz:
https://doaj.org/article/8dad077cc62f4e1189a1a046efddcb2a
Autor:
Andrei Molotkov, Nikunj Bhatt, Mikhail Doubrovin, John Castrillon, Christopher Massa, Adam Gerber, Jeanine D’Armiento, Monica Goldklang, Akiva Mintz
Publikováno v:
Molecular Biomedicine, Vol 1, Iss 1, Pp 1-8 (2020)
Abstract Inflammatory changes caused by viruses, bacteria, exposure to toxins, commonly used drugs and even surgical intervention have the potential of causing abnormal epithelial permeability, which is manifest as infiltrative processes on computed
Externí odkaz:
https://doaj.org/article/8ec095a932fe456a97ffde44e172bdda
Autor:
Andrei Molotkov, Mikhail Doubrovin, Nikunj Bhatt, Fang-Chi Hsu, Amanda Beserra, Rajiv Chopra, Akiva Mintz
Publikováno v:
Drug Delivery, Vol 27, Iss 1, Pp 1686-1694 (2020)
Multimodality 3D Optical Imaging (OI)/CT has the potential to play a major role in drug development for glioblastomas (GBM), as it is an accessible preclinical method. To demonstrate the potential of 3D OI/CT to visualize orthotopic GBM implantation,
Externí odkaz:
https://doaj.org/article/cf5e582a4e624e938411347f7e2f6418
Autor:
Kathleen M. Capaccione, Mikhail Doubrovin, Brian Braumuller, Dev Leibowitz, Nikunj Bhatt, Fatemeh Momen-Heravi, Andrei Molotkov, Michael Kissner, Kimberly Goldner, Mark Soffing, Alessandra Ali, Akiva Mintz
Publikováno v:
Cancers, Vol 14, Iss 19, p 4575 (2022)
Immunotherapy has dramatically improved outcomes for some cancer patients; however, novel treatments are needed for more patients to achieve a long-lasting response. FAP-targeted molecular radiotherapy has shown efficacy in both preclinical and clini
Externí odkaz:
https://doaj.org/article/6349643139974c0d8d39f6bf9fab4c44