Zobrazeno 1 - 10
of 288
pro vyhledávání: '"Akitoshi Ishizaka"'
Publikováno v:
Allergology International, Vol 57, Iss 4, Pp 307-312 (2008)
Prostaglandin D2 (PGD2) is one of the most abundant lipid mediators present in the airways of asthmatics. However, little was known of the role it plays in the pathophysiology of asthma, until the identification of DP (DP1, PTGDR) and CRTH2 (DP2), tw
Externí odkaz:
https://doaj.org/article/b3f15fdcb4714808abae702c2123b2ea
Autor:
Masahito Ebina, Hiroyuki Taniguchi, Taku Miyasho, Shingo Yamada, Naoko Shibata, Hiromitsu Ohta, Shu Hisata, Shinya Ohkouchi, Tsutomu Tamada, Hidekazu Nishimura, Akitoshi Ishizaka, Ikuro Maruyama, Yoshinori Okada, Kondo Takashi, Toshihiro Nukiwa
Publikováno v:
Pulmonary Medicine, Vol 2011 (2011)
The pathogenesis of acute exacerbation of idiopathic pulmonary fibrosis (IPF) remains to be elucidated. To evaluate the roles of inflammatory mediators in acute exacerbation, the concentrations of high mobility group protein B1 (HMGB1), a chief media
Externí odkaz:
https://doaj.org/article/fce6f359a2074833a45ff66deda7e1f4
Autor:
Katsuhisa Tanjoh, Teruo Sakamoto, Akitoshi Ishizaka, Nobuaki Shime, Shigeto Oda, Kenichi Matsuda, Shigeatsu Endo, Hiroyuki Hirasawa, Yasufumi Asai, Joji Kotani, Hiroyuki Yokota, Yoshihiro Yamaguchi
Publikováno v:
Journal of the Japanese Society of Intensive Care Medicine. 21:155-163
Autor:
Yasushi Kawasaki, Masahiro Shinozaki, Shigeatsu Endo, Akitoshi Ishizaka, Nobuyuki Taenaka, Hiroyuki Hirasawa, Yasuhiro Yamamoto, Toshiaki Ikeda, Hisashi Sugimoto, Shuji Shimazaki, Naoki Aikawa
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 24:549-554
Introduction Sivelestat, a neutrophil elastase inhibitor, has been approved in Japan for the treatment of patients with acute lung injury (ALI) associated with systemic inflammatory response syndrome (SIRS). The Pharmaceuticals and Medical Devices Ag
Autor:
Koichiro Asano, Shizuko Kagawa, Koichi Makimura, Koichi Fukunaga, Takahisa Takihara, Tetsuya Shiomi, Kazuo Satoh, Craig M. Lilly, Koichi Sayama, Katsuyoshi Tomomatsu, Akitoshi Ishizaka, Yoshiki Shiraishi, Soichiro Ueda, Yukikazu Natori, Nao Ohmori, Tsuyoshi Oguma, Motohiro Kodama
Publikováno v:
The Journal of Immunology. 187:999-1005
Allergic bronchopulmonary mycosis, characterized by excessive mucus secretion, airflow limitation, bronchiectasis, and peripheral blood eosinophilia, is predominantly caused by a fungal pathogen, Aspergillus fumigatus. Using DNA microarray analysis o
Autor:
Shinnosuke Ikemura, Akitoshi Ishizaka, Katsuhiko Naoki, Sohei Nakayama, Takashi Sato, Satoshi Yoda, Ichiro Kawada, Yuichiro Hayashi, Hideki Terai, Hideo Watanabe, Ichiro Nakachi, Hiroyuki Yasuda, Ryosuke Satomi, Kenzo Soejima
Publikováno v:
Lung Cancer. 72:32-38
Purpose Bronchoscopic microsampling (BMS) is a novel and direct method with which to obtain epithelial lining fluid (ELF) from the lungs. Analysis of DNA hypermethylation of tumor suppressor genes (TSGs) is expected to be a sensitive tool for the ear
Autor:
Satoshi Ogawa, Toshihisa Anzai, Shingo Yamada, Akitoshi Ishizaka, Hideyuki Shimizu, Ryohei Yozu, Takashi Kohno, Hidehiro Kaneko, Tsutomu Yoshikawa, Yasuo Sugano
Publikováno v:
Heart and Vessels. 26:306-312
High-mobility group box 1 protein (HMGB1) is a late mediator of inflammatory responses that can cause acute lung injury. We examined the significance of serum HMGB1 elevation in the development of systemic inflammatory response syndrome (SIRS) and lu
Autor:
Carolyn S. Calfee, Sandra Brady, Jin Woo Song, Akitoshi Ishizaka, Harold R. Collard, Dong Soon Kim, Talmadge E. King, Paul J. Wolters, Kirk D. Jones, Sang-Bum Hong, Michael A. Matthay
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 299:L3-L7
Little is known about the pathobiology of acute exacerbation of idiopathic pulmonary fibrosis (IPF), a condition that shares clinical and histopathological features with acute lung injury. Plasma biomarkers have been well studied in acute lung injury
Autor:
Wakako Yamada-Yamasawa, Tatsu Matsuzaki, Koichi Fukunaga, Koichi Sayama, Kazuhiro Yamaguchi, Haruhiko Hakuno, Akitoshi Ishizaka, Koichiro Asano, Hiroyasu Kudoh, Rika Hiraoka, Takahiro Nakajima, Yosuke Harada, Akira Nagabukuro, Tsuyoshi Oguma
Publikováno v:
Respirology. 15:849-854
BACKGROUND AND OBJECTIVE Whether beta(2)-adrenoceptor gene (ADRB2) polymorphisms are associated with airway responsiveness to beta(2)-agonist medications remains controversial, partly due to factors that may confound pharmacogenetic associations, inc
Autor:
Tomoko Hagiwara, Satoru Hashimoto, Minoru Okamoto, Kazufumi Kawasako, Hiroya Takeuchi, Yosuke Funakoshi, Ikuro Maruyama, Yoshiro Saikawa, Kazuhiro Suganuma, Taku Miyasho, Shingo Yamada, Koichi Suda, Akitoshi Ishizaka, Norihito Wada, Hiroshi Yokota, Yuko Kitagawa, Koichi Fukunaga
Publikováno v:
Shock. 33:526-531
Sivelestat sodium hydrate is a selective inhibitor of neutrophil elastase, which is effective in acute lung injury associated with systemic inflammatory response syndrome. However, the effectiveness of sivelestat in sepsis has not been fully examined