Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Akito Nakamura"'
Autor:
Tomoko Yamamori Morita, Jie Yu, Yukie Kashima, Ryo Kamata, Gaku Yamamoto, Tatsunori Minamide, Chiaki Mashima, Miyuki Yoshiya, Yuta Sakae, Toyohiro Yamauchi, Yumi Hakozaki, Shun-ichiro Kageyama, Akito Nakamura, Eric Lightcap, Kosuke Tanaka, Huifeng Niu, Karuppiah Kannan, Akihiro Ohashi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Serine/threonine kinase, cell division cycle 7 (CDC7) is critical for initiating DNA replication. TAK-931 is a specific CDC7 inhibitor, which is a next-generation replication stress (RS) inducer. This study preclinically investigates TAK-931
Externí odkaz:
https://doaj.org/article/0ad38046919642518f26ad29da7900e3
Autor:
Yuhong Zhang, Akito Nakamura, Keli Song, Stephen Grossman, Kristina Xega, Allison Berger, Gary Shapiro, Dennis Huszar
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/f03ad2073dd44c508bc2e84bcae80caa
Autor:
Sei Yoshida, Tomoyasu Ishikawa, Masanori Okaniwa, Katherine Galvin, Elizabeth Carideo, Jouhara Chouitar, Jill Donelan, Shuntarou Tsuchiya, Takeo Arita, Akito Nakamura
PDF file - 614K, Cellular effects of TAK-632, vemurafenib, and TAK-733 on MAPK signaling (S1); Model describing RAF paradoxical activation (S2); Effects of TAK-632 and vemurafenib on BRAF kinase activity (S3); Reversibility of TAK-632 and vemurafenib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdcaf05c51ce47ecf2912f5b05346bc5
https://doi.org/10.1158/0008-5472.22398855.v1
https://doi.org/10.1158/0008-5472.22398855.v1
Autor:
Sei Yoshida, Tomoyasu Ishikawa, Masanori Okaniwa, Katherine Galvin, Elizabeth Carideo, Jouhara Chouitar, Jill Donelan, Shuntarou Tsuchiya, Takeo Arita, Akito Nakamura
PDF file - 103K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6e57be0280b50c7eb627a772539273
https://doi.org/10.1158/0008-5472.22398852
https://doi.org/10.1158/0008-5472.22398852
Autor:
Sei Yoshida, Tomoyasu Ishikawa, Masanori Okaniwa, Katherine Galvin, Elizabeth Carideo, Jouhara Chouitar, Jill Donelan, Shuntarou Tsuchiya, Takeo Arita, Akito Nakamura
PDF file - 119K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed2773d2e203edffde7e16a28cb8d4c
https://doi.org/10.1158/0008-5472.22398858.v1
https://doi.org/10.1158/0008-5472.22398858.v1
Autor:
Akito Nakamura, Stephen Grossman, Keli Song, Kristina Xega, Yuhong Zhang, Donna Cvet, Allison Berger, Gary Shapiro, Dennis Huszar
Publikováno v:
Blood. 139(18)
Small ubiquitin-like modifier (SUMO) is a member of a ubiquitin-like protein superfamily. SUMOylation is a reversible posttranslational modification that has been implicated in the regulation of various cellular processes including inflammatory respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c72ba378a9c4ab18e8f4fa3cba8349
https://pubmed.ncbi.nlm.nih.gov/35511190
https://pubmed.ncbi.nlm.nih.gov/35511190
Autor:
Osamu Kurasawa, Yasutomi Asano, Ke Li, Hiroshi Banno, Jun Fujimoto, Georgia Kefala, Gyorgy Snell, Irena Levin, Takuto Kojima, Ryo Mizojiri, Bi-Ching Sang, Richard Tjhen, Michael G. Klein, Scott Weston Lane, Isaac Hoffman, Tsuyoshi Ishii, Douglas R. Cary, Xin Liu, Akito Hata, Tadahiro Nambu, Yasuyuki Debori, Tomoya Sameshima, Terufumi Takagi, Steve C. Ding, Akito Nakamura, Maki Miyamoto
Publikováno v:
ACS Med Chem Lett
[Image: see text] General control nonderepressible 2 (GCN2) is a master regulator kinase of amino acid homeostasis and important for cancer survival in the tumor microenvironment under amino acid depletion. We initiated studies aiming at the discover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662a272fad1883740a1bb55324dbb6d0
https://doi.org/10.1021/acsmedchemlett.9b00400
https://doi.org/10.1021/acsmedchemlett.9b00400
Publikováno v:
Estuarine, Coastal and Shelf Science. 219:210-222
Hypoxic water masses are usually formed in the bottom layer of stratified water columns. However, we found that hypoxia was formed throughout the water column in a well-mixed macrotidal estuary, the Rokkaku River Estuary, Japan. There was a spring-ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f2a497c2512f117912e5ac182debdb5
https://doi.org/10.1016/j.ecss.2019.02.011
https://doi.org/10.1016/j.ecss.2019.02.011
Autor:
Tomoko Yamamori Morita, Jie Yu, Yukie Kashima, Kosuke Tanaka, Tatsunori Minamide, Chiaki Mashima, Yumi Hakozaki, Shun-ichiro Kageyama, Akito Nakamura, Eric Lightcap, Huifeng Niu, Karuppiah Kannan, Akihiro Ohashi
Publikováno v:
Cancer Research. 82:5687-5687
Background: The serine/threonine kinase, cell division cycle 7 (CDC7), is critical for initiating DNA replication. A highly specific CDC7 inhibitor, TAK-931, was developed as a next-generation of replication stress (RS) inducer. This study preclinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd27cef435224cf50a21251699c83e7f
https://doi.org/10.1158/1538-7445.am2022-5687
https://doi.org/10.1158/1538-7445.am2022-5687
Autor:
Akito Nakamura, Keli Song, Stephen Grossman, Kristina Xega, Yuhong Zhang, Allison Berger, Gary Shapiro, Dennis Huszar
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background TAK-981 is a first-in-class small molecule inhibitor of the SUMO activating enzyme in Phase 1 clinical trials. SUMOylation has previously been implicated in the regulation of innate immune responses and expression of Type I interferons,1 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f510f489fff22056799fa04914ae4a0
https://doi.org/10.1136/jitc-2020-sitc2020.0552
https://doi.org/10.1136/jitc-2020-sitc2020.0552