Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Akito Kume"'
Autor:
Tatsuya Hattori, Shigeo Kamitsuji, K. Misu, Takashi Ito, Gen Sobue, Hirohisa Watanabe, Todd A. Johnson, Yu Koike, Akito Kume, Naoyuki Kamatani
Publikováno v:
Medicine
Supplemental Digital Content is available in the text
Background: Cellular energetics play an important role in Parkinsons disease etiology, but no treatments directly address this deficiency. Our past research showed that treatment with febuxos
Background: Cellular energetics play an important role in Parkinsons disease etiology, but no treatments directly address this deficiency. Our past research showed that treatment with febuxos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450cf4b0676a1732aa052b32ead095e5
http://europepmc.org/articles/PMC7458241
http://europepmc.org/articles/PMC7458241
Autor:
Hirohisa Watanabe, Tatsuya Hattori, Akito Kume, Kenichiro Misu, Takashi Ito, Yu Koike, Johnson, Todd A., Shigeo Kamitsuji, Naoyuki Kamatani, Gen Sobue, Watanabe, Hirohisa, Hattori, Tatsuya, Kume, Akito, Misu, Kenichiro, Ito, Takashi, Koike, Yu, Kamitsuji, Shigeo, Kamatani, Naoyuki, Sobue, Gen
Publikováno v:
Medicine; 8/28/2020, Vol. 99 Issue 35, p1-8, 8p
Publikováno v:
Nihon Naika Gakkai Zasshi. 102:2023-2033
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe44afb53e19b7e854d623a45e5ae63e
https://doi.org/10.2169/naika.102.2023
https://doi.org/10.2169/naika.102.2023
Autor:
Hiroyasu Ito, Mitsunobu Tadokoro, Mihoko Senda, Hidemaro Sato, Akiharu Furuta, Hitomi Yokoyama, Takashi Hattori, Yoshimasa Nagao, Shigeki Sawada, Hajime Araki, Takuo Hirota, Hiromitsu Nonomura, Akito Kume
Publikováno v:
Nihon Toseki Igakkai Zasshi. 36:207-215
レストレスレッグ症候群 (RLS) は慢性血液透析患者に多くみられ, 周期性四肢運動 (periodic limbs movements: PLM) を伴うことが多い. 欧米では本症に対するドーパミン製剤の有効性が示されてい
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ac335d725006fa0bcd58b421668600f
https://doi.org/10.4009/jsdt.36.207
https://doi.org/10.4009/jsdt.36.207
Publikováno v:
Journal of Neurochemistry. 62:602-607
The effect of Zn2+ on t-[3H]butylbicycloorthobenzoate ([3H]TBOB) binding to the GABAA receptor complex was studied autoradiographically in rat brain. Zn2+ inhibited [3H]TBOB binding in a dose-dependent manner at physiological concentrations. Saturati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd52c1c33c9540b18b5338eb4e1ec46
https://doi.org/10.1046/j.1471-4159.1994.62020602.x
https://doi.org/10.1046/j.1471-4159.1994.62020602.x
Autor:
Akito Kume, Yuji Nakagomi, Hisayoshi Niwa, Hiroaki Adachi, Masahisa Katsuno, Mei Li, Chen Sang, Yasushi Kobayashi, Manabu Doyu, Gen Sobue
Publikováno v:
Neuron. 35:843-854
Spinal and bulbar muscular atrophy (SBMA) is a polyglutamine disease caused by the expansion of a CAG repeat in the androgen receptor (AR) gene. We generated a transgenic mouse model carrying a full-length AR containing 97 CAGs. Three of the five lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8bd435afd6ee356b08613a53286d764
https://doi.org/10.1016/s0896-6273(02)00834-6
https://doi.org/10.1016/s0896-6273(02)00834-6
Autor:
Akito Kume
Publikováno v:
Neuropsychiatric Disease and Treatment
Gabapentin enacarbil is a prodrug of the anticonvulsant gabapentin. The efficacy and safety of gabapentin enacarbil for the treatment of moderate to severe primary restless legs syndrome (RLS) has been evaluated in several clinical trials in the Unit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a159caf069d8ef8e666e60c328d687
https://pubmed.ncbi.nlm.nih.gov/24523590
https://pubmed.ncbi.nlm.nih.gov/24523590
Publikováno v:
Journal of Biological Chemistry. 275:8772-8778
Spinal and bulbar muscular atrophy (SBMA) is one of a group of human inherited neurodegenerative diseases caused by polyglutamine expansion. We have previously demonstrated that the SBMA gene product, the androgen receptor protein, is toxic and aggre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b317f48f5945e3ea47d0537eceedfa
https://doi.org/10.1074/jbc.275.12.8772
https://doi.org/10.1074/jbc.275.12.8772
Publikováno v:
Biochemical and Biophysical Research Communications. 252:145-150
Spinal and bulbar muscular atrophy (SBMA) is one of a group of human inherited neurodegenerative diseases caused by polyglutamine expansion. There is increasing evidence that generation of truncated proteins containing an expanded polyglutamine tract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4aacc68d37db2dc4c909a33b62c770f
https://doi.org/10.1006/bbrc.1998.9624
https://doi.org/10.1006/bbrc.1998.9624
Autor:
Robert A. Koeppe, Michael R. Kilbourn, Akito Kume, David E. Kuhl, Kirk A. Frey, Roger L. Albin
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 17:919-931
This work compares equilibrium to kinetic analysis of positron emission tomography data for the assessment of vesicular monoamine transporter (VMAT2) binding density using (+)-α-[11C]dihydrotetrabenazine ((+)-α-[11C]DTBZ). Studies were performed fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe701444f7cd564257452ce13613489
https://doi.org/10.1097/00004647-199709000-00001
https://doi.org/10.1097/00004647-199709000-00001