Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Akira Yamaki"'
Autor:
Naomi Morozumi, Takafumi Yotsumoto, Akira Yamaki, Kazunori Yoshikiyo, Sayaka Yoshida, Ryuichi Nakamura, Toshimasa Jindo, Mayumi Furuya, Hiroaki Maeda, Yoshiharu Minamitake, Kenji Kangawa
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212680 (2019)
C-type natriuretic peptide (CNP) and its receptor natriuretic peptide receptor B (NPR-B) are physiological potent positive regulators of endochondral bone growth; therefore, the CNP/NPR-B signaling pathway is one of the most promising therapeutic tar
Externí odkaz:
https://doaj.org/article/a23874efccb247c8b70edd59fc1c6e1e
Autor:
Takehiko Iwaki, Makoto Iwanami, Kazuo Miyazaki, Yoshiaki Oyama, Naomi Morozumi, Yamato Suzuki, Akira Yamaki, Taisaku Tanaka, Mayumi Furuya, Yoshihiko Okamura
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:6680-6694
Natriuretic peptide receptor A (NPR-A) agonists were evaluated in vivo by optimizing the structure of quinazoline derivatives to improve agonistic activity for rat NPR-A. A 1,4-Cis-aminocyclohexylurea moiety at 4-position and hydroxy group of d -alan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0c239c0e40b61bf3df44ebf5e53911e
https://doi.org/10.1016/j.bmc.2017.11.006
https://doi.org/10.1016/j.bmc.2017.11.006
ASB20123: A novel C-type natriuretic peptide derivative for treatment of growth failure and dwarfism
Autor:
Hiroaki Maeda, Takafumi Yotsumoto, Mayumi Furuya, Kenji Kangawa, Sayaka Yoshida, Akira Yamaki, Toshimasa Jindo, Kazunori Yoshikiyo, Naomi Morozumi, Yoshiharu Minamitake, Ryuichi Nakamura
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212680 (2019)
PLoS ONE
PLoS ONE
C-type natriuretic peptide (CNP) and its receptor natriuretic peptide receptor B (NPR-B) are physiological potent positive regulators of endochondral bone growth; therefore, the CNP/NPR-B signaling pathway is one of the most promising therapeutic tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f63811ea749e941bc93bda915fd6559
https://doaj.org/article/a23874efccb247c8b70edd59fc1c6e1e
https://doaj.org/article/a23874efccb247c8b70edd59fc1c6e1e
Autor:
Yoshihiko Okamura, Toshiyuki Tomoo, Akira Yamaki, Takehiko Iwaki, Mayumi Furuya, Masako Sugiyama, Taisaku Tanaka, Yoshiaki Oyama
Publikováno v:
Bioorganicmedicinal chemistry. 25(6)
Novel agonists of the Natriuretic Peptide Receptor A (NPR-A) were obtained through random screening and subsequent structural modification of triazine derivatives. The key structural feature to improve in vitro activity was the dimerization of triazi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d71c7e6188f8c089f295fbfbd43bf2
https://pubmed.ncbi.nlm.nih.gov/28190653
https://pubmed.ncbi.nlm.nih.gov/28190653
Autor:
Sayaka Yoshida, Seiji Sato, Kazuhiro Ohsuye, Yoshiharu Minamitake, Norio Ohnuma, Norio Inomata, Naomi Morozumi, Mayumi Furuya, Akira Yamaki, Kenji Kangawa
Publikováno v:
Peptides. 33:279-284
Ghrelin consists of 28 amino acid residues with an octanoyl modification at the third serine residue. Recently we have found that the C-terminal part of ghrelin protects the ester bond of 3-octanoyled serine from plasma esterases and plays the essent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::821e694e3ac3bffd8fa703666e4efebe
https://doi.org/10.1016/j.peptides.2012.01.010
https://doi.org/10.1016/j.peptides.2012.01.010
Autor:
Hiromi Habara, Takashi Nakatsuka, Yoshiharu Minamitake, Kenji Kangawa, Naomi Morozumi, Kazuhiro Ohsuye, Mayumi Furuya, Akira Yamaki, Norio Inomata, Takeshi Hanada
Publikováno v:
Peptides. 32:1001-1007
Ghrelin is an endogenous ligand for growth hormone secretagogue receptor 1a (GHS-R1a), and consists of 28 amino acid residues with octanoyl modification at Ser(3). The previous studies have revealed that N-terminal part of ghrelin including modified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddcb4dce6873fa1438f43dc510883b1f
https://doi.org/10.1016/j.peptides.2011.01.021
https://doi.org/10.1016/j.peptides.2011.01.021
Autor:
Tadashi Miyamoto, Myung-Woo Hwang, Koh Ono, Ryosuke Nishio, Akira Yamaki, Masatake Hara, Kanjo Yamamoto, Youichi Nunokawa, Katsura Kitaura-Inenaga, Akira Matsumori
Publikováno v:
European Journal of Heart Failure. 6:137-144
Background: Nuclear factor kappa B (NF-κB) is activated by several factors, which increase the inflammatory response, and this activation, in turn, leads to the expression of several genes such as cytokines, and may play an important role in cardiov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1d5e5fb2ee7aeac122b4e854b930d4a
https://doi.org/10.1016/j.ejheart.2003.10.007
https://doi.org/10.1016/j.ejheart.2003.10.007
Autor:
Toshinori Hidaka, Akira Yamaki, Chikako Takiguchi, Makoto Shibata, Mikiko Miya, Norio Inomata, Tomoe Kamei, Akira Mizuno, Toshio Tatsuoka, Kyoko Nakanishi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 48:1129-1137
As an extension of our previous investigation, a series of 7-aminoalkylpyrrolo[2,3-c]azepine derivatives was synthesized and evaluated as alpha1-adrenergic- and serotonin 2 (5-HT2)-receptor antagonists, with the aim of finding a novel potent antihype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc82e07084bdcd0e161134e3cef9200
https://doi.org/10.1248/cpb.48.1129
https://doi.org/10.1248/cpb.48.1129
Autor:
Kei Hayashi, Akira Takeuchi, Hwi-Yool Kim, Ryohei Nishimura, Akira Yamaki, Satoru Matsunaga, Nobuo Sasaki
Publikováno v:
Journal of Veterinary Medical Science. 57:99-104
Cardiopulmonary effects of medetomidine (20 micrograms/kg)-midazolam (0.3 mg) (Me-Mi) were compared with those of medetomidine alone (80 micrograms/kg) (Me80) in dogs. The intramuscular administration of this combination caused bradycardia and transi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5419354d0539722eb55cd847fbd2a176
https://doi.org/10.1292/jvms.57.99
https://doi.org/10.1292/jvms.57.99
Autor:
Norio Inomata, Masako Sugiyama, Akira Yamaki, Yoshiharu Minamitake, Mayumi Furuya, Kenji Kangawa, Kazuhiro Ohsuye
Publikováno v:
Regulatory peptides. 178(1-3)
Ghrelin is a gastric peptide that regulates energy homeostasis. Angiotensin II (Ang II) is known to induce body weight loss and skeletal muscle catabolism through the ubiquitin–proteasome pathway. In this study, we investigated the effects of ghrel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8546b1aed37eb8473c6e4b50647cfb23
https://pubmed.ncbi.nlm.nih.gov/22750276
https://pubmed.ncbi.nlm.nih.gov/22750276