Zobrazeno 1 - 10
of 207
pro vyhledávání: '"Akira Tokumura"'
Autor:
Toshihiko Tsutsumi, Syougo Yamakawa, Akira Ishihara, Aimi Yamamoto, Tamotsu Tanaka, Akira Tokumura
Publikováno v:
Toxicology Reports, Vol 2, Iss C, Pp 121-129 (2015)
Aristolochic acid (AA) is considered to be a causative agent for progressive interstitial renal fibrosis, leading to AA nephropathy. Lysophosphatidic acid (LPA) is a mediator in the onset of renal fibrosis. In this study, we analyzed the molecular sp
Externí odkaz:
https://doaj.org/article/c94b171a92bd40ceb815306a53c4f46b
Publikováno v:
International Journal of Medical Sciences, Vol 6, Iss 4, Pp 168-176 (2009)
Systemic sclerosis (SSc) is an often fatal disease characterized by autoimmunity and inflammation, leading to widespread vasculopathy and fibrosis. Lysophosphatidic acid (LPA), a bioactive phospholipid in serum, is generated from lysophospholipids se
Externí odkaz:
https://doaj.org/article/2bd7f85742894a49a705bc0143d7c432
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 11, Pp 2145-2150 (2004)
Lysophosphatidic acid (LPA) is a lipid mediator that may play an important role in wound healing, embryonic development, and progression of cancer. Here, we report a procedure for the quantification of LPA by matrix-assisted laser desorption/ionizati
Externí odkaz:
https://doaj.org/article/89a74fe61941406bbd9b51af5fc8b5d1
Autor:
Takayuki Sugiura, Shinji Nakane, Seishi Kishimoto, Keizo Waku, Yasuko Yoshioka, Akira Tokumura
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 12, Pp 2049-2055 (2002)
Lysophosphatidic acid is a multifunctional phospholipid mediator and elicits a variety of biological responses in vitro and in vivo. Evidence is accumulating that lysophosphatidic acid plays important physiological roles in diverse mammalian tissues
Externí odkaz:
https://doaj.org/article/b4a04a1079e3429d805028760a0f68e0
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 2, Pp 307-315 (2002)
Lysophosphatidic acid (LPA) is a biologically active phospholipid that has been identified as a vasoactive principle in incubated plasma and serum of mammals. Previously, we found that mammalian plasma and serum contain a lysophospholipase D, which h
Externí odkaz:
https://doaj.org/article/a547e4b752d945f1903bed21a8991b07
Autor:
Akira Tokumura, Tuneki Sumida, Masaoki Toujima, Kentaro Kogure, Kenji Fukuzawa, Yoshitaka Takahashi, Shozo Yamamoto
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 6, Pp 953-962 (2000)
Phosphatidylcholines (PCs) with platelet-activating factor (PAF)-like biological activities are known to be generated by fragmentation of the sn-2-esterified polyunsaturated fatty acyl group. The reaction is free radical-mediated and triggered by oxi
Externí odkaz:
https://doaj.org/article/b3e3ba6d3da34eae8b4627dd5ef6b628
Autor:
Kohei Kawabata, Yuichiro Sato, Takanori Kubo, Akira Tokumura, Hiroyuki Nishi, Kinjiro Morimoto
Publikováno v:
Archives of Virology. 168
Autor:
Yasuo Okamoto, Tatsuya Tai, Yasuhiro Takenouchi, Hitoshi Houchi, Keisuke Kitakaze, Junko Matsuda, Kazuhito Tsuboi, Akira Tokumura, Takashi Watanabe, Tamotsu Tanaka, Hanif Ali, Natsuo Ueda, Yoko Okamoto, Ryouhei Yamashita, Iffat Ara Sonia Rahman, Shinji Go, Toru Uyama
Publikováno v:
The FASEB Journal. 35
Publikováno v:
Prostaglandins, Leukotrienes and Essential Fatty Acids. 139:40-48
Plasma n-3 fatty acids are important as the supplying pool of n-3 fatty acids to various tissues including the brain, although the relationship between dietary n-3 fatty acids and their molecular species in the plasma are not fully clarified. We inve
Autor:
Yoko Okamoto, Tamotsu Tanaka, Toshihiko Tsutsumi, Mayumi Hidaka, Yuta Atsumi, Naoki Shirasaka, Masatoshi Shiojiri, Akira Tokumura, Manami Inoue
Publikováno v:
BioFactors. 44:548-557
Oral administration of lysophosphatidic acid (LPA), a critical intercellular lipid mediator, exerts wound healing and antiulcer effects on gastrointestinal system. To evaluate effects of food-derived LPA on body homeostasis, we measured LPA levels by