Výsledky vyhledávání - "Akira TAKANAKA"

Simultaneous Assessment of the In Vivo Amount of CYP1A2 and CYP3A2 by the PKCYP-test Using Theophylline in Rats

Autor: Miyoko Hayashi, Akira Takanaka, Noriko Matsunaga, Keiko Yamamoto, Emi Nakashima, Kazuyo Nishihara, Junko Kizu, Akinobu Morikawa, Taeko Nishijima

Publikováno v: Drug Metabolism and Pharmacokinetics. 17:190-198

Summary: Recently, we developed a method for assessing in vivo drug metabolism capacity by pharmacokinetic estimation of the quantity of cytochrome P450 (CYP) in vivo (PKCYP-test), in which an apparent liver-to-blood free concentration gradient in vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::805e9500f8d03d3ae75bf4938a3cbcc0
https://doi.org/10.2133/dmpk.17.190

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Autor: AKIRA TAKANAKA

Publikováno v: Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 32:217-222

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7fc88bfb23a2b9136a2fca437c121e3d
https://doi.org/10.3999/jscpt.32.5_217

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A Simplified Diagnostic Approach for Estimating in vivo Hepatic Drug Clearance. Its Preliminary Application for the Drug Caffeine, Using CYP1A Probe in a Rat Model

Autor: Akira Takanaka, Hisashi Iizasa, Noriko Matsunaga, Kenji Hattori, Morio Fukuhara, Emi Nakashima

Publikováno v: Japanese Journal of Hospital Pharmacy. 26:492-504

A novel approach for identifying the inter-individual variation in hepatic clearance was investigated based on physiological pharmacokinetic studies and estimations of the amount of cytochrome P450 (CYP)in vivo. This approach is referred to as the PK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac52300a3a36974d4c9e0e3d1c9b8605
https://doi.org/10.5649/jjphcs1975.26.492

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Isolation and Characterization of Four Cytochrome P450 Isozymes from Untreated and Phenobarbital-Treated Beagle Dogs

Autor: Toshiaki Tamura, Toshifumi Shiraga, Kazuyoshi Nozaki, Kazuhide Iwasaki, Ryuichi Kato, Akira Takanaka, Yasushi Yamazoe

Publikováno v: Biological and Pharmaceutical Bulletin. 17:22-28

Four different forms of cytochrome P450 (P450) were purified from liver microsomes of untreated or phenobarbital (PB)-treated male beagle dogs using HPLC techniques, and designated as DUT-1, DPB-1, DPB-2 and DPB-3, respectively. Specific contents of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe33b2716b681c38b8439c4d0aee36c
https://doi.org/10.1248/bpb.17.22

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Oxysterols Inhibit Gap Junctional Communication between Rat Hepatocytes in Primary Culture

Autor: Xinbiao Guo, Yasuo Ohno, Momoko Sunouchi, Atsuko Miyajima, Akira Takanaka

Publikováno v: Pharmacology & Toxicology. 73:10-13

Several oxysterols were examined for their effect on gap junctional communication between rat hepatocytes in primary culture. 25-Hydroxycholesterol, 22(S)-hydroxycholesterol and 7 beta-hydroxycholesterol, in decreasing order of potency, markedly inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7093350e57d9014b676f7cecfd713134
https://doi.org/10.1111/j.1600-0773.1993.tb01949.x

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Effect of OM-853, a Cerebral Metabolic Ameliorator, on Ambulatory Activity and Passive and Active Avoidance Responses in Mice and Mongolian Gerbils

Autor: Kazuhide Inoue, Ken Nakazawa, Tomokazu Watano, Akira Takanaka, Tomoko Obama, Kannosuke Fujimori, Mayumi Mori

Publikováno v: Japanese Journal of Pharmacology. 61:351-356

Effects of hirsuteine, an indole alkaloid extracted from Uncaria genus, on nicotine and high K-induced responses were investigated in rat pheochromocytoma PC12 cells. Hirsuteine (300 nM-10 μM)inhibited dopamine release evoked by 100 μM nicotine in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54502ab2bc0325afd839adb93c4ecd31
https://doi.org/10.1254/jjp.61.351

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Neurochemical and histological analysis of motor dysfunction observed in rats with methylnitrosourea-induced experimental cerebellar hypoplasia

Autor: Ken Nakazawa, Kazuhide Inoue, Akira Takanaka, Kannosuke Fujimori, Makoto Shibutani, Akihiko Maekawa

Publikováno v: Neurochemical Research. 17:223-231

Histological and neurochemical changes related to motor dysfunction observed in rats after neonatal treatment with nitrosoureas were examined. Neonatal rats received subcutaneous injections of methylnitrosourea (MNU: 0.125 mmol/kg, s.c.) or ethylnitr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::333c49c5804e51b2437c92b13f7f92ce
https://doi.org/10.1007/bf00966663

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