Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Akira Shigenaga"'
Autor:
Misaki Yamasaki, Yuika Seto, Mizune Ozono, Michiyasu Nakao, Akira Shigenaga, Akira Otaka, Shigeki Sano, Kentaro Kogure
Publikováno v:
Biochemistry and Biophysics Reports, Vol 31, Iss , Pp 101329- (2022)
Tocopheryl succinate (Tsuc) is a succinic acid ester of the well-known antioxidant α-tocopherol (T). Tsuc exhibits various biological activities, including tumor growth suppression via activation of cell signaling and prevention of lipid accumulatio
Externí odkaz:
https://doaj.org/article/022f4f93669a43458f13f76f7057687a
Autor:
Kosuke Tanegashima, Rena Takahashi, Hideko Nuriya, Rina Iwase, Naoto Naruse, Kohei Tsuji, Akira Shigenaga, Akira Otaka, Takahiko Hara
Publikováno v:
EBioMedicine, Vol 24, Iss C, Pp 247-256 (2017)
CXCL14 is a primordial chemokine that plays multiple roles in tumor suppression, autoimmune arthritis, and obesity-associated insulin resistance. However, the underlying molecular mechanisms are unclear. Here, we show that CXCL14 transports various t
Externí odkaz:
https://doaj.org/article/f048954521c2406293e2893fe84fb88f
Autor:
Akira Shigenaga, Ryuji Kyan
Publikováno v:
Journal of Peptide Science.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54d26d29bfe5856b0ee0a77c30f088a7
https://doi.org/10.1002/psc.3526
https://doi.org/10.1002/psc.3526
Autor:
Kento Ohkawachi, Kaito Anzaki, Daishiro Kobayashi, Ryuji Kyan, Takuma Yasuda, Masaya Denda, Norio Harada, Akira Shigenaga, Nobuya Inagaki, Akira Otaka
Publikováno v:
Chemistry – A European Journal. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f590f06931a4b06221752a350c98cca0
https://doi.org/10.1002/chem.202301087
https://doi.org/10.1002/chem.202301087
Autor:
Kento Ohkawachi, Kaito Anzaki, Daishiro Kobayashi, Ryuji Kyan, Takuma Yasuda, Masaya Denda, Norio Harada, Akira Shigenaga, Nobuya Inagaki, Akira Otaka
Publikováno v:
Chemistry – A European Journal. 29
A tyrosine (Tyr)- or tryptophan (Trp)-selective metal-free C−H sulfenylation reaction using an acid-activated Sacetamidomethyl cysteine (Cys) sulfoxide, Cys(Acm)(O), has been achieved. The dually protonated intermediate produced from the Cys(Acm)(O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::213b3d0a84322bea9e0fdbb83bad9764
https://doi.org/10.1002/chem.202300799
https://doi.org/10.1002/chem.202300799
Autor:
Keiichiro Okuhira, Masahiro Ueda, Sayuki Arii, Chiaki Komiya, Kohshi Kusumoto, Masaya Denda, Akira Otaka, Akira Shigenaga
Publikováno v:
Chemical and Pharmaceutical Bulletin. 68:1226-1232
Proteins incorporating artificial moieties such as fluorophores and drugs have enjoyed increasing use in chemical biology and drug development research. Preparation of such artificial protein derivatives has relied mainly on native chemical ligation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07fe82bc6bad4245b401156305f4332f
https://doi.org/10.1248/cpb.c20-00674
https://doi.org/10.1248/cpb.c20-00674
Autor:
Masaya Denda, Kenzo Yamatsugu, Akira Shigenaga, Daishiro Kobayashi, Motomu Kanai, Akira Otaka, Kento Ohkawachi, Kyohei Morimoto
Publikováno v:
Organic Letters. 22:5289-5293
Sulfanylmethyl-installed dimethylaminopyridine, 2-sulfanylmethyl-4-dimthylaminopyridine (SMDMAP) (2), has an acidic thiol group comparable to that in aryl thiols due to the formation of a zwitterion consisting of a thiolate anion and a pyridinium cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2887779636f2e6caf954ffa1dbe3cc98
https://doi.org/10.1021/acs.orglett.0c01383
https://doi.org/10.1021/acs.orglett.0c01383
Publikováno v:
Chemical and Pharmaceutical Bulletin. 68:216-219
A turn-on fluorescent traceable linker based on N-sulfanylethylcoumarinyl amide (SECmide) has been developed as an advanced cleavable linker. It was successfully employed for the enrichment and selective visualization of a target protein in cell lysa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d27e94e25a8366777c85d7a93f94e61
https://doi.org/10.1248/cpb.c19-00726
https://doi.org/10.1248/cpb.c19-00726
Autor:
Daiki Sato, Masaya Denda, Honoka Tsunematsu, Naonobu Tanaka, Isamu Konishi, Chiaki Komiya, Akira Shigenaga, Akira Otaka
Publikováno v:
Chemical communications (Cambridge, England). 58(17)
Intramolecular S-acylation of a thiol-installed threonine with a thioester unit, followed by S–O acyl transfer and subsequent desulphurisation, allows the synthesis of lactone peptides. A protocol has been developed enabling the cyclisation of a li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::826f7dc9d1297f902c2ca5ed3cd51ded
https://pubmed.ncbi.nlm.nih.gov/35138311
https://pubmed.ncbi.nlm.nih.gov/35138311
Autor:
Akira Shigenaga
Publikováno v:
Chemical and Pharmaceutical Bulletin. 67:1171-1178
Peptides and proteins are involved in almost all biological events. In this review, three chemical biology tools, which were developed for peptide/protein sciences from a viewpoint of peptide/amide bond cleavage, are overviewed. First, study on an ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b956288804c43eafc0a25f1deb7a79de
https://doi.org/10.1248/cpb.c19-00285
https://doi.org/10.1248/cpb.c19-00285