Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Akira Orimo"'
Autor:
Gilar Gorji-Bahri, B. Madhu Krishna, Catharina Hagerling, Akira Orimo, Karin Jirström, Konstantinos S. Papadakos, Anna M. Blom
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Cartilage oligomeric matrix protein (COMP), an extracellular matrix glycoprotein, is vital in preserving cartilage integrity. Further, its overexpression is associated with the aggressiveness of several types of solid cancers. Thi
Externí odkaz:
https://doaj.org/article/70cd2d9352ca489783d89fb5d55c6172
Autor:
Yu Koyama, Hiroya Okazaki, Yang Shi, Yoshihiro Mezawa, Zixu Wang, Mizuki Sakimoto, Akane Ishizuka, Yasuhiko Ito, Takumi Koyama, Yataro Daigo, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Keisuke Sugahara, Okio Hino, Liying Yang, Reo Maruyama, Akira Katakura, Takehiro Yasukawa, Akira Orimo
Publikováno v:
Cancer Medicine, Vol 12, Iss 17, Pp 18062-18077 (2023)
Abstract Background Cancer‐associated fibroblasts (CAFs) are a major stromal component of human breast cancers and often promote tumor proliferation, progression and malignancy. We previously established an experimental CAF (exp‐CAF) cell line eq
Externí odkaz:
https://doaj.org/article/96ae5b868f724f33af3c3e73ed1001ff
Autor:
Mary E. Vail, Rae H. Farnsworth, Linda Hii, Stacey Allen, Sakshi Arora, Robin L. Anderson, Ross A. Dickins, Akira Orimo, Sunny Z. Wu, Alexander Swarbrick, Andrew M. Scott, Peter W. Janes
Publikováno v:
Cancers, Vol 15, Iss 18, p 4646 (2023)
Tumour progression relies on interactions with untransformed cells in the tumour microenvironment (TME), including cancer-associated fibroblasts (CAFs), which promote blood supply, tumour progression, and immune evasion. Eph receptor tyrosine kinases
Externí odkaz:
https://doaj.org/article/9d8a73af1e864d829344ef73149a816e
Autor:
Moe Iwai, Miniwan Tulafu, Shinsaku Togo, Hideya Kawaji, Kotaro Kadoya, Yukiko Namba, Jin Jin, Junko Watanabe, Takahiro Okabe, Moulid Hidayat, Issei Sumiyoshi, Masayoshi Itoh, Yu Koyama, Yasuhiko Ito, Akira Orimo, Kazuya Takamochi, Shiaki Oh, Kenji Suzuki, Yoshihide Hayashizaki, Koji Yoshida, Kazuhisa Takahashi
Publikováno v:
Molecular Oncology, Vol 15, Iss 5, Pp 1507-1527 (2021)
Cancer‐associated fibroblasts (CAFs) regulate cancer progression through the modulation of extracellular matrix (ECM) and cancer cell adhesion. While undergoing a series of phenotypic changes, CAFs control cancer–stroma interactions through integ
Externí odkaz:
https://doaj.org/article/59f288c8b9f746ce98c609c24bd321d1
Autor:
Yoshihiro Mezawa, Yataro Daigo, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Chikao Morimoto, Okio Hino, Akira Orimo
Publikováno v:
Cancer Medicine, Vol 8, Iss 8, Pp 3936-3948 (2019)
Abstract Human breast carcinoma‐associated fibroblasts (CAFs) increasingly acquire both transforming growth factor‐β (TGF‐β) and stromal cell‐derived factor‐1 (SDF‐1) signaling in an autocrine fashion during tumor progression. Such sign
Externí odkaz:
https://doaj.org/article/3cb462969a8e43af962fd30472279db1
Autor:
Gentaro Taniguchi, Kazunori Kajino, Shuji Momose, Harumi Saeki, Liang Yue, Naomi Ohtsuji, Masaaki Abe, Tomoyoshi Shibuya, Akira Orimo, Akihito Nagahara, Sumio Watanabe, Okio Hino
Publikováno v:
Cancers, Vol 14, Iss 9, p 2198 (2022)
The expression of Renal Carcinoma (ERC)/mesothelin is enhanced in a variety of cancers. ERC/mesothelin contributes to cancer progression by modulating cell signals that regulate proliferation and apoptosis. Based on such biological insights, ERC/meso
Externí odkaz:
https://doaj.org/article/b5f956eb01ae4be392d0d40f7c47afef
Autor:
Takahiro Okabe, Shinsaku Togo, Yuichi Fujimoto, Junko Watanabe, Issei Sumiyoshi, Akira Orimo, Kazuhisa Takahashi
Publikováno v:
Cancers, Vol 12, Iss 12, p 3588 (2020)
Metastasis-related events are the primary cause of cancer-related deaths, and circulating tumor cells (CTCs) have a pivotal role in metastatic relapse. CTCs include a variety of subtypes with different functional characteristics. Interestingly, the e
Externí odkaz:
https://doaj.org/article/9859d8b116894690b450de113ab1e2bf
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 9, p 2256 (2019)
Neoplastic epithelial cells coexist in carcinomas with various non-neoplastic stromal cells, together creating the tumor microenvironment. There is a growing interest in the cross-talk between tumor cells and stromal fibroblasts referred to as carcin
Externí odkaz:
https://doaj.org/article/ce222bc951854a2588d5803f10d098e2
Publikováno v:
Cancers, Vol 5, Iss 1, Pp 149-169 (2013)
Human carcinomas frequently exhibit significant stromal reactions such as the so-called “desmoplastic stroma” or “reactive stroma”, which is characterised by the existence of large numbers of stromal cells and extracellular matrix proteins. C
Externí odkaz:
https://doaj.org/article/e0ea4f208a224ff8b996eb18191d14f1
Autor:
AI KOYANAGI, KAZUNORI KAJINO, SHUKO NOJIRI, MASAAKI ABE, TOSHIYUKI KOBAYASHI, YOSHINOBU SUGITANI, LIANG YUE, NAOMI OHTSUJI, ATSUSHI ARAKAWA, TADASHI SATO, KAZUHISA TAKAHASHI, KENJI SUZUKI, AKIRA ORIMO, TAKASHI YAO, OKIO HINO
Publikováno v:
Juntendo Medical Journal. 69:124-136