Zobrazeno 1 - 10
of 288
pro vyhledávání: '"Akira Nakai"'
Autor:
Ryosuke Takii, Mitsuaki Fujimoto, Akanksha Pandey, Kritika Jaiswal, Linda Shearwin-Whyatt, Frank Grutzner, Akira Nakai
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract The heat shock response (HSR) is a universal mechanism of cellular adaptation to elevated temperatures and is regulated by heat shock transcription factor 1 (HSF1) or HSF3 in vertebrate endotherms, such as humans, mice, and chickens. We here
Externí odkaz:
https://doaj.org/article/bf613dcba9b848a183159d003a88a632
Autor:
Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Here the authors show phosphorylation of heat shock factor 1 (HSF1) at S419 via the chromatin-bound kinase PLK1, promotes HSF1 recruitment of histone acetyltransferases and histone acetylation reader proteins TRIM33 and TRIM24, which actually also ex
Externí odkaz:
https://doaj.org/article/3d2c83e829734453be6b4ba57f6b16e5
Autor:
Ming Liu, Yumei Fan, Danyu Li, Bihui Han, Yanxiu Meng, Fei Chen, Tianchan Liu, Zhiyuan Song, Yu Han, Liying Huang, Yanzhong Chang, Pengxiu Cao, Akira Nakai, Ke Tan
Publikováno v:
Molecular Oncology, Vol 15, Iss 8, Pp 2084-2105 (2021)
Despite recent progress in non‐small‐cell lung cancer (NSCLC) treatment, treatment outcomes remain poor, mainly because of treatment resistance or toxicity. Erastin is a ferroptosis inducer that has shown promising cytotoxic effects in various ty
Externí odkaz:
https://doaj.org/article/7052dfc54dfe4155bf7bef5c7b5c4949
Autor:
Arpit Katiyar, Mitsuaki Fujimoto, Ke Tan, Ai Kurashima, Pratibha Srivastava, Mariko Okada, Ryosuke Takii, Akira Nakai
Publikováno v:
FEBS Open Bio, Vol 10, Iss 6, Pp 1135-1148 (2020)
The mitochondrial unfolded protein response (UPRmt) is characterized by the transcriptional induction of mitochondrial chaperone and protease genes in response to impaired mitochondrial proteostasis and is regulated by ATF5 and CHOP in mammalian cell
Externí odkaz:
https://doaj.org/article/ed47cad0ab0a4a8099f07a67a712671f
Autor:
Mitsuaki Fujimoto, Ryosuke Takii, Eiichi Takaki, Arpit Katiyar, Ryuichiro Nakato, Katsuhiko Shirahige, Akira Nakai
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
PARP1 recruitment to DNA lesions is critical for DNA damage repair but how DNA damage induces PARP1 redistribution is largely unknown. Here, the authors provide evidence that PARP1 redistribution and DNA repair in tumor cells depend on the formation
Externí odkaz:
https://doaj.org/article/3d6ffc8f89924108bb617e1a5c7fc6ea
Autor:
Seiji Ishii, Masaaki Torii, Alexander I. Son, Meenu Rajendraprasad, Yury M. Morozov, Yuka Imamura Kawasawa, Anna C. Salzberg, Mitsuaki Fujimoto, Kristen Brennand, Akira Nakai, Valerie Mezger, Fred H. Gage, Pasko Rakic, Kazue Hashimoto-Torii
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Prenatal exposure to environmental stressors is known to impair cortical development. Here the authors show that upon exposure to stressors, the activation of Hsf1-Hsp signalling is highly variable among cells in the embryonic cortex of mice, and eit
Externí odkaz:
https://doaj.org/article/799a96f9df824be3a9794751c745b994
Autor:
Takehito Kondo, Ichiro Hisatome, Shouichi Yoshimura, Endang Mahati, Tomomi Notsu, Peili Li, Kazuhiko Iitsuka, Masaru Kato, Kazuyoshi Ogura, Junichiro Miake, Takeshi Aiba, Wataru Shimizu, Yasutaka Kurata, Shinji Sakata, Naoe Nakasone, Haruaki Ninomiya, Akira Nakai, Katsumi Higaki, Yasushi Kawata, Yasuaki Shirayoshi, Akio Yoshida, Kazuhiro Yamamoto
Publikováno v:
Journal of Arrhythmia, Vol 32, Iss 5, Pp 433-440 (2016)
Background: The human ether-a-go-go-related gene (HERG) encodes the α-subunit of rapidly activating delayed-rectifier potassium channels. Mutations in this gene cause long QT syndrome type 2 (LQT2). In most cases, mutations reduce the stability of t
Externí odkaz:
https://doaj.org/article/5d4db3e2c36644959f8332cdfd40f7fb
Autor:
Ryosuke Takii, Mitsuaki Fujimoto, Yuki Matsuura, Fangxu Wu, Namiko Oshibe, Eiichi Takaki, Arpit Katiyar, Hiroshi Akashi, Takashi Makino, Masakado Kawata, Akira Nakai
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180776 (2017)
Cells cope with temperature elevations, which cause protein misfolding, by expressing heat shock proteins (HSPs). This adaptive response is called the heat shock response (HSR), and it is regulated mainly by heat shock transcription factor (HSF). Amo
Externí odkaz:
https://doaj.org/article/f5f93fbc608e4ec1bbfbcc17a538ce35
Autor:
Yukihiro Horie, Akira Nakai, Shigeaki Ohno, Nobuyoshi Kitaichi, Kousuke Noda, Satoru Kase, Anton Lennikov, Susumu Ishida
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 1, Pp 2175-2189 (2013)
Acute ultraviolet (UV) B exposure causes photokeratitis and induces apoptosis in corneal cells. Geranylgeranylacetone (GGA) is an acyclic polyisoprenoid that induces expression of heat shock protein (HSP)70, a soluble intracellular chaperone protein
Externí odkaz:
https://doaj.org/article/1f3332d7ba9746eea07d7e07229c2b91
Autor:
Yoshiaki Yamagata, Koichiro Nishino, Eiichi Takaki, Shun Sato, Ryo Maekawa, Akira Nakai, Norihiro Sugino
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83612 (2014)
The objective of this study was to characterize the genome-wide DNA methylation profiles of isolated endometrial stromal cells obtained from eutopic endometria with (euESCa) and without endometriosis (euESCb) and ovarian endometrial cysts (choESC). T
Externí odkaz:
https://doaj.org/article/06eeb3ab3d1b4713b30cfdc946034701