Zobrazeno 1 - 10
of 1 958
pro vyhledávání: '"Akira NAKAMURA"'
Autor:
Tsubasa Tanaka, Tamaki Yano, Shingo Usuki, Yoko Seo, Kento Mizuta, Maho Okaguchi, Maki Yamaguchi, Kazuko Hanyu-Nakamura, Noriko Toyama-Sorimachi, Katja Brückner, Akira Nakamura
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract RNA interference (RNAi) is a gene-silencing mechanism triggered by the cytosolic entry of double-stranded RNAs (dsRNAs). Many animal cells internalize extracellular dsRNAs via endocytosis for RNAi induction. However, it is not clear how the
Externí odkaz:
https://doaj.org/article/07329bdfa98a45bfa711d24abbdee6c2
Pyogenic liver abscess associated with Klebsiella oxytoca: Mimicking invasive liver abscess syndrome
Autor:
Takanobu Iwadare, Takefumi Kimura, Ayumi Sugiura, Risa Takei, Masato Kamakura, Shun-ichi Wakabayashi, Taiki Okumura, Daichi Hara, Akira Nakamura, Takeji Umemura
Publikováno v:
Heliyon, Vol 9, Iss 11, Pp e21537- (2023)
A pyogenic liver abscess (PLA) is a space-occupying lesion in the liver that is associated with significant morbidity and mortality. We herein present the case of a Japanese 76-year-old man who visited our hospital with fever and back pain lasting 3
Externí odkaz:
https://doaj.org/article/b85408407cd94cf991ddb56af7f930b3
Autor:
Cecilia Leñini, Facundo Rodriguez Ayala, Anibal Juan Goñi, Liliana Rateni, Akira Nakamura, Roberto Ricardo Grau
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Spore-forming probiotic bacteria offer interesting properties as they have an intrinsic high stability, and when consumed, they are able to survive the adverse conditions encountered during the transit thorough the host gastrointestinal (GI) tract. A
Externí odkaz:
https://doaj.org/article/3c6a2c61d50c46a98cd9949a6996da15
Publikováno v:
FEBS Open Bio, Vol 12, Iss 11, Pp 2057-2064 (2022)
Proteinaceous protease inhibitors can strongly and specifically inhibit cognate proteases, but their use as pharmaceuticals is limited by their size. As such, the development of effective protease peptide inhibitors would be beneficial for biochemica
Externí odkaz:
https://doaj.org/article/f5d0b02b811644a192a4639016147429
Autor:
Tomonori Kaifu, Takumi Maruhashi, Soo-Hyun Chung, Kenji Shimizu, Akira Nakamura, Yoichiro Iwakura
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Dendritic cell immunoreceptor (DCIR) is an inhibitory C-type lectin receptor that acts as a negative regulator in the immune system and bone metabolism. We previously revealed that DCIR deficiency enhanced osteoclastogenesis and antigen presentation
Externí odkaz:
https://doaj.org/article/abeeffd923b04c9b8238870d97abdd04
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Aberrant RNA condensates are a hallmark of age-related neurodegenerative diseases. Here, the authors show that RNA condensation increases in aging Drosophila brains, triggering translation repression.
Externí odkaz:
https://doaj.org/article/56426d671f674b16bad902b37e3393b2
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101739- (2022)
Summary: eIF5-mimic protein (5MP) controls translation through binding to the ribosomal pre-initiation complex (PIC) and alters non-AUG translation rates for cancer oncogenes and repeat-expansions in neurodegenerative diseases. Here, we describe a se
Externí odkaz:
https://doaj.org/article/02676ba38bcb4cbe8ed6184e6cd9bd2a
Autor:
Yuto Yoshinari, Hina Kosakamoto, Takumi Kamiyama, Ryo Hoshino, Rena Matsuoka, Shu Kondo, Hiromu Tanimoto, Akira Nakamura, Fumiaki Obata, Ryusuke Niwa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Incretin hormones regulate insulin and glucagon secretion in mammals, but similar peptides have not been characterized in invertebrates. Here the authors show that neuropeptide F functions similar to mammalian incretin in fruit flies, responding to s
Externí odkaz:
https://doaj.org/article/b4166c8f5f8449ef8b5ce6a3391e52f3
Autor:
Hiroko Sano, Akira Nakamura, Mariko Yamane, Hitoshi Niwa, Takashi Nishimura, Kimi Araki, Kazumasa Takemoto, Kei-Ichiro Ishiguro, Hiroki Aoki, Yuzuru Kato, Masayasu Kojima
Publikováno v:
PLoS Biology, Vol 20, Iss 6, p e3001678 (2022)
Cells must adjust the expression levels of metabolic enzymes in response to fluctuating nutrient supply. For glucose, such metabolic remodeling is highly dependent on a master transcription factor ChREBP/MondoA. However, it remains elusive how glucos
Externí odkaz:
https://doaj.org/article/207b80fd7a99461ea601010cac36638a
Autor:
Hiroyuki Hisada, Yu Takahashi, Manabu Kubota, Haruhisa Shimura, Ei Itobayashi, Kenji Shimura, Akira Nakamura
Publikováno v:
BMC Gastroenterology, Vol 21, Iss 1, Pp 1-9 (2021)
Abstract Background Colorectal cancer (CRC) is one of the most common cancers in the world. The number of elderly patients with CRC increases due to aging of the population. There are few studies that examined chemotherapy and prognostic factors in m
Externí odkaz:
https://doaj.org/article/57d19dbb09964f248ee1877ddc77e587