Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Akira Maruden"'
1
REPRODUCTIVE AND DEVELOPMENTAL TOXICITY STUDIES OF FUT-187 (III) : Postnatal Study in Rat F1 Offspring from Dams Treated Orally with FUT-187 : During the Period of Fetal Organogenesis
Autor: Tsutomu Takeshima, Setsuo Imai, Kazunori Shimamura, Akira Maruden, Yo Igarashi, Shunji Toyohara, Motonari Shiraishi, Hiroaki Kawanishi
Publikováno v: The Journal of Toxicological Sciences. 17:231-252
A postnatal study of F1 offspring exposed to FUT-187 during fetal organogenesis was carried out using Crj: CD rat. FUT-l87 was dosed by gavage at 0, 50, 200 and 800 mg/kg/day from day 7 to 17 of gestation. All pregnant rats were allowed to deliver ne
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::343866ff6e6a60c791b83b9fbadd7523
https://doi.org/10.2131/jts.17.supplementiv_231
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2
REPRODUCTIVE AND DEVELOPMENTAL TOXICITY STUDIES OF FUT-187 (I) : Fertility Study in Rats with Oral Administration of FUT-187
Autor: Ryouichi Yoshida, Akira Maruden, Tadakazu Furuhashi, Masami Uehara, Rie Kodama, Kazunori Shimamura
Publikováno v: The Journal of Toxicological Sciences. 17:201-219
FUT-187 was given orally at 20, 120 and 720 mg/kg during the pre-pairing period (63 days prior to pairing in males and 14 days prior to pairing in females) and the pairing period to male and female rats and in the early stage of pregnancy (days 0 thr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c362db2af4f29494158ee9e9da5d3370
https://doi.org/10.2131/jts.17.supplementiv_201
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3
A 52-WEEK ORAL CHRONIC TOXICITY STUDY OF 6-AMIDINO-2-NAPHTHYL 4- [4, 5-DIHYDRO-1H-IMIDAZOL-2-YL) AMINO] BENZOATE DIMETHANESULFONATE (FUT-187) IN RATS WITH A RECOVERY PERIOD OF 5 WEEKS
Autor: Shuzo Okazaki, Eiich Yamazaki, Takayuki Aikawa, Kazutoshi Tamura, Kazuhisa Hatayama, Keitaro Terazawa, Akira Maruden
Publikováno v: The Journal of Toxicological Sciences. 17:125-162
The chronic toxicity of FUT-187, a synthetic protease inhibitor, was investigated in Sprague-Dawley rats. FUT-187 was given orally to the rats at doses of 0.4, 2, 10, 50 and 250 mg/kg/day for 52 weeks. The drug was then withdrawn for 5 weeks. The res
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbfbfb505700088fee779dd2ed3f5239
https://doi.org/10.2131/jts.17.supplementiv_125
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4
The evaluation of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino] benzoate dimethanesulfonate (FUT-187) by oral administration in cynomolgus monkeys in a 13 week subacute toxicity study
Autor: Keitaro Terazawa, Eric J. F. Spicer, Akira Maruden
Publikováno v: The Journal of toxicological sciences. 17
To assess the subacute toxicity of 6-amidino-2-naphthyl 4-[ (4, 5-dihydro-1H-imidazol-2-yl) amino] benzoate dimethanesulfonate (FUT-187) a 13 week subacute toxicity study by gavage was done in Cynomolgus monkeys at dosage levels of 0, 15, 45 and 135
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb88a37d5dc8a5ef179acc8a12233b7a
https://pubmed.ncbi.nlm.nih.gov/1296020
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5
[Reproductive and developmental toxicity studies of FUT-187. (V)--Perinatal and postnatal study in rats with oral administration of FUT-187]
Autor: Akira Maruden, Kazunori Shimamura, Hitoshi Kurihara, Akiko Takei, Tadakazu Furuhashi, Ryouichi Yoshida, Masami Uehara
Publikováno v: The Journal of toxicological sciences. 17
FUT-187 was given orally at 20, 120 and 720 mg/kg to female rats during the perinatal and postnatal periods and the effect on dams and offspring were evaluated. One dam during the terminal period of gestation and 3 dams after delivery in the 720 mg/k
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb4efa0b31ee667d48b5ce9d155dcca8
https://pubmed.ncbi.nlm.nih.gov/1296026
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6
[Reproductive and developmental toxicity study of 6-amidino-2-naphthyl 4(-)[(4,5-dihydro-1H-imidazol-2-yl) amino] benzoate dimethanesulfonate (FUT-187). (II)--Oral administration to rats during the period of fetal organogenesis (prenatal examination)
Autor: Yasuki Yokomoto, Kazuyoshi Watanabe, Keitaro Terazawa, Akira Maruden, Norio Hasegawa, Mikio Terabayashi, Shigeru Kuramoto, Kazunori Shimamura, Kyoko Otani
Publikováno v: The Journal of toxicological sciences. 17
6-Amidino-2-naphthyl 4(-)[(4,5-dihydro-1H-imidazol-2-yl) amino] benzoate dimethanesulfonate (FUT-187) was given orally to pregnant Crj : CD (Sprague-Dawley) rats from days 7 through 17 of gestation at dose levels of 50, 200 and 800 mg/kg/day. In the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970816d1f17087a501b20c31d94c1387
https://pubmed.ncbi.nlm.nih.gov/1369754
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7
[A 13-week subacute oral toxicity study of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl) amino] benzoate dimethanesulfonate (FUT-187) in rats]
Autor: Shuzo OKAZAKI, Asahi TODATE, Eiichi YAMAZAKI, Kazuhiro ANABUKI, Kazutoshi TAMURA, Toru HOSHIYA, Akira MARUDEN, Keitaro TERAZAWA
Publikováno v: The Journal of toxicological sciences. 17
The toxicity of FUT-187, a synthetic protease inhibitor, was investigated in Sprague-Dawley rats. FUT-187 was given orally to the rats at doses of 2, 10, 50, 250 and 1250 mg/kg/day for 13 weeks, then the drug was withdrawn for 5 weeks for recovery. T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f70dd726b03b6b5f0a201752b3aa7a1
https://pubmed.ncbi.nlm.nih.gov/1296023
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8
[Reproductive and developmental toxicity studies of 6-amidino-2-naphthyl 4(-)[(4,5-dihydro-1H-imidazol-2-yl) amino] benzoate dimethanesulfonate (FUT-187). (IV)--Oral administration to New Zealand white rabbits during the period of fetal organogenesis
Autor: Keitaro Terazawa, Kazunori Shimamura, Mikio Terabayashi, Shigeru Kuramoto, Akira Maruden, Norio Hasegawa
Publikováno v: The Journal of toxicological sciences. 17
Oral administration of 6-amidino-2-naphthyl 4(-)[(4,5-dihydro-1H-imidazol-2-yl)amino] benzoate dimethanesulfonate (FUT-187) at doses of 10, 30 and 100 mg/kg was given to New Zealand White rabbits on days 6 to 18 of gestation. The following results we
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f65eceb3f94c139a690b3e234f3144
https://pubmed.ncbi.nlm.nih.gov/1369755
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9
[A thirteen-week oral repeated dose toxicity study of suplatast tosilate (IPD-1151T) in rats]
Autor: Shigeki NAKANO, Taiji HAYASHI, Kenji IRIMURA, Akira MARUDEN, Kazutoshi NAKAGAWA, Ken-ichi MORITA
Publikováno v: The Journal of toxicological sciences. 17
A 13-week oral repeated dose toxicity study of Suplatast tosilate (IPD-1151T), a new anti-allergic agent, as well as a 5-week recovery study were carried out at dose levels of 0 (control), 200, 600, 1800 and 5400 mg/kg/day using male and female rats.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf354e36e0abd8d09ff3ffde1a47e4ed
https://pubmed.ncbi.nlm.nih.gov/1321257
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