Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Akira Kosasayama"'
Autor:
Miki Toshikura, Mika Yoshida, Shoichi Funabashi, Akimoto Yamada, Kazuko Yoshioka, Kunihisa Nasu, Seizaburo Okada, Akira Kosasayama
Publikováno v:
Pharmacoepidemiology and drug safety. 8(1)
We surveyed the safety and effectiveness of 13 drug products under the reexamination system in Japan. Until the time of reexamination, a total of 106,328 case reporting forms were collected in the drug use investigations, while 1340 adverse drug reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f808a7b1d6a5b5624e398a5024c313be
https://pubmed.ncbi.nlm.nih.gov/15073944
https://pubmed.ncbi.nlm.nih.gov/15073944
Publikováno v:
Chemical and Pharmaceutical Bulletin. 27:880-892
Synthesis of linear and angular tricyclic guanidine derivatives, imidazo- or pyrimido-[2, 1-b]- or [1, 2-a] quinazoline derivatives, is described. Cyclization of 2-(ω-chloroalkyl)-4-phenyl-3, 4-dihydroquinazolines (9) gave two isomers and their isol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b3eee89ab8d50732d4b91c8abd7cf4
https://doi.org/10.1248/cpb.27.880
https://doi.org/10.1248/cpb.27.880
Autor:
Takeo Sakurai, Makoto Sato, Fumihiko Uchimaru, Akira Kosasayama, Hiroshi Kojima, Hiroaki Tagawa, Terukiyo Yamasaki
Publikováno v:
Chemical and Pharmaceutical Bulletin. 26:3296-3305
In order to search for new psychotropic agents, several 1-butanone derivatives (VIII) substituted by pyridine, indole or quinoline were synthesized. And the carbonyl group of VIII was modified to methylene (XII), secondary alcohol (XIII) and vinyl (X
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0713640c6a52af11b6e43b4602b35c95
https://doi.org/10.1248/cpb.26.3296
https://doi.org/10.1248/cpb.26.3296
Publikováno v:
Chemical and Pharmaceutical Bulletin. 26:3658-3665
Reaction of 2-benzylaminoethylamine (1a) with cyanogen bromide was investigated under various conditions to obtain desired 1-benzyl-2-iminoimidazolidine (2a) in quantitative yield. In addition, in the presence of base this reaction gave 3-carbamoyl d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc9383eed080ead4d557de3b008ef61a
https://doi.org/10.1248/cpb.26.3658
https://doi.org/10.1248/cpb.26.3658
Publikováno v:
Chemical and Pharmaceutical Bulletin. 26:3666-3674
Synthesis of acyl and alkyl derivatives of 1-benzyl or 1-benzhydryl-2-imino-1, 3-diazacycloalkanes (1) was attempted. Acetylation of 1a, c having five-membered ring with ethyl acetate gave 2-acetyl derivatives. However, reactions of 1a, c with dialky
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70fd0102e02b6d1c87990e85ca2cca8b
https://doi.org/10.1248/cpb.26.3666
https://doi.org/10.1248/cpb.26.3666
Publikováno v:
Chemical and Pharmaceutical Bulletin. 27:841-847
Synthesis of N-benzhydryl bicyclic guanidines (12) was attempted. The key intermediates, 1-benzhydryl-2-N- or 3-(ω-hydroxyalkyl)-2-imino-1, 3-diazacycloalkanes (4) and (9) were prepared. The intramolecular cyclization of 4 to 12 was not advantageous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe90c5f0ec004938f95b31d041f9f6a
https://doi.org/10.1248/cpb.27.841
https://doi.org/10.1248/cpb.27.841
Publikováno v:
Chemical and Pharmaceutical Bulletin. 28:2024-2028
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::296dccafc3a02c9fefb5e9a640198e45
https://doi.org/10.1248/cpb.28.2024
https://doi.org/10.1248/cpb.28.2024
Publikováno v:
Chemical and Pharmaceutical Bulletin. 29:2885-2892
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83bff367a9bf47b86d4d4d2afac90557
https://doi.org/10.1248/cpb.29.2885
https://doi.org/10.1248/cpb.29.2885
Publikováno v:
Chemical and Pharmaceutical Bulletin. 19:1344-1357
Extensive works have been made of the preparation of six sets of 2-substituted pyrazine 4-oxide and its isomeric new 1-oxide by unambiguous route, and of the reaction between substituted pyrazine mono-N-oxides and a series of halogenation reagents an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab761d1f371bfad20aeafc673acb0220
https://doi.org/10.1248/cpb.19.1344
https://doi.org/10.1248/cpb.19.1344
Publikováno v:
Chemical and Pharmaceutical Bulletin. 20:2204-2208
The nuclear magnetic resonance parameter of disubstituted pyrazines have been correlated with the chemical structure. The coupling constants of 2, 3-, 2, 5-, 2, 6-disubstituted pyrazines are 2.5-3.0, 1.1-1.4, 0 Hz respectively, and these values are n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d125a90d0d1285638496410666f65779
https://doi.org/10.1248/cpb.20.2204
https://doi.org/10.1248/cpb.20.2204