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Upregulation of Retinal Vascular Endothelial Growth Factor mRNAs in Spontaneously Diabetic Rats without Ophthalmoscopic Retinopathy

Publikováno v: Ophthalmic Research. 30:333-339

Vascular endothelial growth factor (VEGF) has recently been shown to be involved in the pathogenesis of proliferative diabetic retinopathy. However, its involvement in the development of the early phase of diabetic retinopathy is not fully understood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd8b8a8c579b1e8fc1a983a272d52289
https://doi.org/10.1159/000055493

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A practical synthesis of the [(2R)-3-(morpholinocarbonyl)-2-(1-naphthylmethyl)propionyl]-L-histidine moiety (P4-P2) in renin inhibitors

Autor: Atsushi Tsubaki, Toshiaki Yamaguchi, Tetsuhide Kamijo, Akira Iyobe, Kinji Iizuka, Yoshiaki Kiso, Hiromu Harada, Katsuyuki Ogura

Publikováno v: The Journal of Organic Chemistry. 55:1679-1682

We describe a convenient and practical method for synthesizing N-[(2R)-3-(morpholinocarbonyl)-2-(1-naphthylmethyl) propionyl]-L-histidine methyl ester, which is useful as a common precursor (P 4 -P 2 moiety) for the syntheses of renin inhibitors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::990c3ae10f5589f49a9c70e426d18764
https://doi.org/10.1021/jo00292a052

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Studies on new platelet aggregation inhibitors 1. Synthesis of 7-nitro-3,4-dihydroquinoline-2(1H)-one derivatives

Autor: Kouji Kamata, Masahiko Uchida, Yukihiko Hotei, Akira Iyobe, Hiroshi Kusama, Hiromu Harada

Publikováno v: Chemicalpharmaceutical bulletin. 49(7)

A series of 6-cyclic aliphatic amino-7-nitro-3,4-dihydroquinoline-2(1H)-ones were prepared and tested for platelet aggregation inhibitory effect, cardiotonic activity and chronotropic activity. These compounds appeared to show selective inhibitory ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf5179411fdf053a692d7b09a3c2327
https://pubmed.ncbi.nlm.nih.gov/11456086

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Synthesis and structure-activity relationships of human renin inhibitors designed from angiotensinogen transition state

Autor: Iwao Shimaoka, Kenji Akahane, Tetsuhiro Kubota, Tetsuhide Kamijo, Toshiaki Yamaguchi, Makoto Murakami, Hideaki Umeyama, Atsushi Tsubaki, Yoshiaki Kiso, Kinji Iizuka, Yasuo Etoh, Akira Iyobe, Hiromu Harada

Publikováno v: Chemicalpharmaceutical bulletin. 38(9)

The synthesis and the structure-activity relationships of renin inhibitors designed from the angiotensinogen transition state are described. These inhibitors contained residues modified at P1-P1', P2, and P4-P3. Decrease in the size of side chain alk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7981f2e4e9833a67f9886feef107764c
https://pubmed.ncbi.nlm.nih.gov/2285979

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A practical synthesis of an orally potent renin inhibitor, isopropyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-{N-[(2R)-2-morpholinocarbonylmethyl-3-(1-naphthyl)propionyl]-L-histidyl}aminobutyrate

Autor: Kazuma Hirata, Yoshiaki Kiso, Atsushi Tsubaki, Kinji Iizuka, Akira Iyobe, Takashi Yamaguchi, Hiromu Harada, Tetsuhide Kamijo

Publikováno v: Journal of the Chemical Society, Perkin Transactions 1. :2497

The practical synthesis of an orally potent human renin inhibitor, isopropyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-{N-[(2R)-2-morpholinocarbonylmethyl-3-(1-naphthyl)propionyl]-L-histidyl}-aminobutyrate, is presented. Optically pure cyclohexylnorstatine is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6210fd88b8d6c90724c24a1da0ea1b7e
https://doi.org/10.1039/p19900002497

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Successful asymmetric Diels-Alder approach to optically active C-nucleosides. Enantioselective total synthesis of D-showdomycin and D-2,5-anhydroallose derivatives

Autor: Toru Koizumi, Akira Iyobe, Hiromitsu Takayama

Publikováno v: Chemical and Pharmaceutical Bulletin. 35:433-435

Using an asymmetric Diels-Alder reaction of (S)S-3- (2-pyridylsulfinyl) acrylate with furan, a highly enantioselective synthesis of a common key intermediate (+) - (1) was achieved, and this was successfully converted to C-nucleosides, D-showdomycin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de6168d27926105eaa0d6449f71f4e87
https://doi.org/10.1248/cpb.35.433

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ChemInform Abstract: Successful Asymmetric Diels-Alder Approach to Optically Active C-Nucleosides. Enantioselective Total Synthesis of D-Showdomycin and D-2,5- Anhydroallose Derivatives

Autor: Akira Iyobe, Hiromitsu Takayama, Toru Koizumi

Publikováno v: ChemInform. 18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::338a3086c6dfdb83e7366d06d942b1d0
https://doi.org/10.1002/chin.198733340

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ChemInform Abstract: The First Efficient Asymmetric Synthesis of 7-Oxabicyclo[2.2.1]hept-5-ene-2-carboxylate Derivatives

Autor: Toru Koizumi, Akira Iyobe, Hiromitsu Takayama

Publikováno v: Chemischer Informationsdienst. 17

The asymmetic synthesis of 7-oxabicyclo[2.2.1]hept-5-ene-2-carboxylate derivatives was accomplished by the highly diastereoselective Diels–Alder reaction of (S)s- and (R)s-3-(2-pyridylsulphinyl)acrylates with furan.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f23f9c19157c71e421858e6fbf7b844
https://doi.org/10.1002/chin.198644064

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