Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Akira Itokawa"'
Autor:
Akira Itokawa, Y. Nishimura, Teruyuki Miyamoto, Hiroshi Egawa, Koh-ichiro Shibamori, Jun-Ichi Matsumoto, Junji Nakano
Publikováno v:
ChemInform. 22
The displacement reactions of ethyl 1-cyclopropyl-5,6,7,8-tetrafluoro-4(1H)-oxoquinoline-3-carboxylate (7) and its carboxylic acid 8 with amine nucleophiles were examined. The nucleophilic displacement occurred regioselectively at the C-5 or C-7 posi
Autor:
Toshikazu Yamaguchi, Makiko Yokogawa, Yutaka Sekine, Masuo Kurono, Akira Itokawa, Motoko Sakashita
Publikováno v:
Drug Metabolism and Pharmacokinetics. 6:21-32
Metabolism of sparfloxacin (5-amino-1-cyclopropy1-7-(cis-3, 5-dimethyl-1-piperazinyl)-6, 8-difluoro-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid), a new synthetic antibacterial agent, was investigated in rats, dogs, monkeys and man after oral admini
Autor:
Teruyuki Miyamoto, Jun-Ichi Matsumoto, Junji Nakano, Koh-ichiro Shibamori, Y. Nishimura, Hiroshi Egawa, Akira Itokawa
Publikováno v:
Chemical and Pharmaceutical Bulletin. 38:2390-2396
The displacement reactions of ethyl 1-cyclopropyl-5,6,7,8-tetrafluoro-4(1H)-oxoquinoline-3-carboxylate (7) and its carboxylic acid 8 with amine nucleophiles were examined. The nucleophilic displacement occurred regioselectively at the C-5 or C-7 posi
Autor:
Yoshitaka Kimura, Yasumasa Doi, Akira Itokawa, Tadahiro Sawayama, Kanji Shimada, Haruki Nishimura
Publikováno v:
Chemical and Pharmaceutical Bulletin. 38:529-531
The synthesis of 1-((S)-3-acetylthio-2-methylpropanoyl)-L-prolyl-L-phenylalanine 1 (alacepril, code name : DU-1219), a clinically used antihypertensive agent, and one of its active metabolites, 1-((S)-3-mercapto-2-methylpropanoyl)-L-prolyl-L-phenylal
Autor:
Hideto Noguchi, Kensuke Namba, Akira Itokawa, Haruki Nishimura, Mizuo Mizuno, Norio Nagamoto, Katsuhisa Nakata, Matao Matsui
Publikováno v:
Planta Medica. 54:305-307
Autor:
NORIO, NAGAMOTO, HIDETO, NOGUCHI, AKIRA, ITOKAWA, KATSUHISA, NAKATA, KENSUKE, NAMBA, HARUKI, NISHIMURA, MATAO, MATSUI, MIZUO, MIZUNO
Publikováno v:
岐阜藥科大學紀要 = The annual proceedings of Gifu College of Pharmacy. 38:79