Výsledky vyhledávání - "Akira Hiratate"

Discovery of novel 2-[(4-hydroxy-6-oxo-2,3-dihydro-1H-pyridine-5-carbonyl)amino]acetic acid derivatives as HIF prolyl hydroxylase inhibitors for treatment of renal anemia

Autor: Akira Hiratate, Makoto Hamada, Lisa Okumura-Kitajima, Hiroko Koretsune, Takumi Naruse, Masato Takahashi, Hiroki Takano, Hiromitsu Kajiyama, Tsuyoshi Shibata, Hiroyuki Kakinuma, Noriko Takayama, Tetsuo Takayama, Sota Kato, Miyoko Yashiro

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 28:1725-1730

Prolyl hydroxylase domain-containing protein (PHD) inhibitors are useful as orally administered agents for the treatment of renal anemia. Based on the common structures of known PHD inhibitors, we found novel PHD inhibitor 1 with a 2-[(4-hydroxy-6-ox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b59ff8d7e0ee30a65221e381e12867
https://doi.org/10.1016/j.bmcl.2018.04.039

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Synthesis of Both Enantiomers of Altholactone, Isoaltholactone and 5-Hydroxygoniothalamin from Tri-O-acetyl-D-glucal, and Their Biological Activities

Autor: Akira Hiratate, Toshiro Noshita, Takayuki Oritani, Ryo Takeuchi, Hiromasa Kiyota

Publikováno v: Journal of Pesticide Science. 26:366-370

前報に続き, アルトラクトン, イソアルトラクトン, 5-ヒドロキシゴニオタラミンの両鏡像体の合成を行った. トリ-O-アセチル-D-グルカールから得られたアセタールに必要な側鎖を延長後, �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a754f0d48c112051efa6fab6afb5e8c4
https://doi.org/10.1584/jpestics.26.366

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Synthesis of (-)-ent-Altholactone, (+)-7a-epi-Altholactone, (-)-ent-Isoaltholactone and (-)-7a-epi-Isoaltholactone from 2, 3-O-Cyclohexylidene-D-glyceraldehyde

Autor: Hiromasa Kiyota, Akira Hiratate, Takayuki Oritani

Publikováno v: Journal of Pesticide Science. 26:361-365

抗腫瘍活性物質アルトラクトン類の合成研究を行った. 2,3-O-シクロヘキシリデン-D-グリセルアルデヒドを出発物質として, 新たに3か所の不斉点を導入する経路を採用し, (-)-ent-アルトラク�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3aa940e5ee67e326014854f49708dcfd
https://doi.org/10.1584/jpestics.26.361

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Discovery of novel (4-piperidinyl)-piperazines as potent and orally active acetyl-CoA carboxylase 1/2 non-selective inhibitors: F-Boc and triF-Boc groups are acid-stable bioisosteres for the Boc group

Autor: Daisuke Yamamoto, Akira Hiratate, Tomomichi Chonan, Miyoko Yashiro, Daisuke Wakasugi, Fusayo Io, Hiroko Koretsune, Hiroaki Tanaka, Ayumi Ohoka-Sugita, Takahiro Oi

Publikováno v: Bioorganicmedicinal chemistry. 19(5)

Novel (4-piperidinyl)-piperazine derivatives were synthesized and evaluated as ACC1/2 non-selective inhibitors. Optimization of the substituents on the nitrogen of the piperidine ring led to the identification of the fluorine substituted tert-butoxyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ea50dd0e25d528dafcbbd54f81a2a0
https://pubmed.ncbi.nlm.nih.gov/21324704

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Design and synthesis of disubstituted (4-piperidinyl)-piperazine derivatives as potent acetyl-CoA carboxylase inhibitors

Autor: Daisuke Yamamoto, Akira Hiratate, Hiroaki Tanaka, Tomomichi Chonan, Miyoko Yashiro, Hiroko Koretsune, Daisuke Wakasugi, Ayumi Ohoka-Sugita, Fusayo Io, Takahiro Oi

Publikováno v: Bioorganicmedicinal chemistry letters. 20(13)

Acetyl-CoA carboxylases (ACCs), the rate limiting enzymes in de novo lipid synthesis, play important roles in modulating energy metabolism. The inhibition of ACC has demonstrated promising therapeutic potential for treating obesity and type 2 diabete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9a1ddd265e2e82373209c50ac95e2b3
https://pubmed.ncbi.nlm.nih.gov/20537533

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(4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors

Autor: Daisuke Wakasugi, Takahiro Oi, Miyoko Yashiro, Hiroaki Tanaka, Ayumi Ohoka-Sugita, Tomomichi Chonan, Akira Hiratate, Fusayo Io, Hiroko Koretsune, Daisuke Yamamoto

Publikováno v: Bioorganicmedicinal chemistry letters. 19(23)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e245dbea7d6c7f08aaf8c4ff99264571
https://pubmed.ncbi.nlm.nih.gov/19853443

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ChemInform Abstract: Synthesis and Structure-Activity Relationships of Potent 1-(2-Substituted-aminoacetyl)-4-fluoro-2-cyanopyrrolidine Dipeptidyl Peptidase IV Inhibitors

Autor: Akira Hiratate, Yuji Takaoka, Hidetaka Saito, Koji Yamamoto, Masato Takahashi, Masako Saito-Hori, Eiji Munetomo, Hiroshi Fukushima, Kiyokazu Kitano

Publikováno v: ChemInform. 40

Dipeptidyl peptidase IV (DPP-IV) inhibitors have attracted attention as potential drugs for use in the treatment of type 2 diabetes because they prevent the degradation of glucagon-like peptide-1 (GLP-1) and extend its duration of action. We previous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f810c958e9575a34e8e4068e27ac6f2
https://doi.org/10.1002/chin.200903194

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Synthesis and structure-activity relationships of potent 1-(2-substituted-aminoacetyl)-4-fluoro-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors

Autor: Koji Yamamoto, Hidetaka Saito, Yuji Takaoka, Kiyokazu Kitano, Hiroshi Fukushima, Masato Takahashi, Eiji Munetomo, Masako Saito-Hori, Akira Hiratate

Publikováno v: Chemicalpharmaceutical bulletin. 56(8)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d853923456c4faef7ae1faa0f5369a40
https://pubmed.ncbi.nlm.nih.gov/18670111

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Synthesis and structure-activity relationships of potent 4-fluoro-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors

Autor: Masato Takahashi, Koji Yamamoto, Eiji Munetomo, Akira Hiratate, Ayako Mikami, Hidetaka Saito, Yuji Takaoka, Akio Suzuki, Kiyokazu Kitano, Sumi Chonan, Masako Saito-Hori, Hiroshi Fukushima

Publikováno v: Bioorganicmedicinal chemistry. 16(7)

Dipeptidyl peptidase IV (DPP-IV) inhibitors are promising antidiabetic drugs, and several drugs are in the developmental stage. We previously reported that the introduction of fluorine to the 4-position of 2-cyanopyrrolidine enhanced the DPP-IV inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd3ee7b09de242be8983aef03c078ce6
https://pubmed.ncbi.nlm.nih.gov/18243000

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Synthesis and structure-activity relationships of potent 3- or 4-substituted-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors

Autor: Kiyokazu Kitano, Eiji Munetomo, Koji Yamamoto, Yuji Takaoka, Hidetaka Saito, Hiroshi Fukushima, Akira Hiratate, Masako Saito, Masato Takahashi

Publikováno v: Bioorganicmedicinal chemistry. 12(23)

Dipeptidyl peptidase IV (DPP-IV) inhibitors have attracted attention as potential drugs for use in the treatment of type 2 diabetes because they prevent degradation of glucagon-like peptide-1 (GLP-1) and extend its duration of action. A series of 2-c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a137022816f9005814bc85aecc1de043
https://pubmed.ncbi.nlm.nih.gov/15519151

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