Zobrazeno 1 - 10
of 415
pro vyhledávání: '"Akira, Ohta"'
Autor:
Ryo Ito, Azuma Kimura, Yurie Hirose, Yu Hatano, Atsushi Mima, Shin-Ichi Mae, Yamato Keidai, Toshihiro Nakamura, Junji Fujikura, Yohei Nishi, Akira Ohta, Taro Toyoda, Nobuya Inagaki, Kenji Osafune
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract For pluripotent stem cell (PSC)-based regenerative therapy against diabetes, the differentiation efficiency to pancreatic lineage cells needs to be improved based on the mechanistic understanding of pancreatic differentiation. Here, we aimed
Externí odkaz:
https://doaj.org/article/df2cb19d80214e9ca8bdf82af4846cfd
Autor:
Keiko Imamura, Yasuteru Sakurai, Takako Enami, Ran Shibukawa, Yohei Nishi, Akira Ohta, Tsugumine Shu, Jitsutaro Kawaguchi, Sayaka Okada, Thomas Hoenen, Jiro Yasuda, Haruhisa Inoue
Publikováno v:
FEBS Open Bio, Vol 11, Iss 5, Pp 1452-1464 (2021)
Human pathogenic RNA viruses are threats to public health because they are prone to escaping the human immune system through mutations of genomic RNA, thereby causing local outbreaks and global pandemics of emerging or re‐emerging viral diseases. W
Externí odkaz:
https://doaj.org/article/4a4e279441aa4abbb5afc6d67541b2f8
Autor:
Naoya Kase, Madoka Terashima, Akira Ohta, Akira Niwa, Fumiko Honda‐Ozaki, Yuri Kawasaki, Tatsutoshi Nakahata, Nobuo Kanazawa, Megumu K. Saito
Publikováno v:
Stem Cells Translational Medicine, Vol 10, Iss 3, Pp 455-464 (2021)
Abstract Nakajo‐Nishimura syndrome (NNS) is an autoinflammatory disorder caused by a homozygous mutations in the PSMB8 gene. The administration of systemic corticosteroids is partially effective, but continuous treatment causes severe side effects.
Externí odkaz:
https://doaj.org/article/ab2d0a8881024d599625298f42662775
Autor:
Mio Iwasaki, Yuka Kawahara, Chikako Okubo, Tatsuya Yamakawa, Michiko Nakamura, Tsuyoshi Tabata, Yohei Nishi, Megumi Narita, Akira Ohta, Hirohide Saito, Takuya Yamamoto, Masato Nakagawa, Shinya Yamanaka, Kazutoshi Takahashi
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104289- (2022)
Summary: The effects of transcription factors on the maintenance and differentiation of human-induced or embryonic pluripotent stem cells (iPSCs/ESCs) have been well studied. However, the importance of posttranscriptional regulatory mechanisms, which
Externí odkaz:
https://doaj.org/article/4e083f7c47a34a7694fd39ebde05df31
Autor:
Rina Hashimoto, Tomokazu Tamura, Yukio Watanabe, Ayaka Sakamoto, Naoko Yasuhara, Hayato Ito, Masahiro Nakano, Hiromitsu Fuse, Akira Ohta, Takeshi Noda, Yasufumi Matsumura, Miki Nagao, Takuya Yamamoto, Takasuke Fukuhara, Kazuo Takayama
Publikováno v:
Molecular Pharmaceutics. 20:2276-2287
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bd8064da3974bb6de02d3beea1e8fef
https://doi.org/10.1021/acs.molpharmaceut.3c00114
https://doi.org/10.1021/acs.molpharmaceut.3c00114
Autor:
Ryosuke Seki, Akira Ohta, Akira Niwa, Yoshinori Sugimine, Haruna Naito, Tatsutoshi Nakahata, Megumu K Saito
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249807 (2021)
[This corrects the article DOI: 10.1371/journal.pone.0237030.].
Externí odkaz:
https://doaj.org/article/4daa609f191e4599bb1cfce6afbcf5c3
Autor:
Ryosuke Seki, Akira Ohta, Akira Niwa, Yoshinori Sugimine, Haruna Naito, Tatsutoshi Nakahata, Megumu K Saito
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237030 (2020)
Curative therapeutic options for a number of immunological disorders remain to be established, and approaches for identifying drug candidates are relatively limited. Furthermore, phenotypic screening methods using induced pluripotent stem cell (iPSC)
Externí odkaz:
https://doaj.org/article/9243bc070a9a43988d330ee257141c7c
Autor:
Kyosuke Hino, Chengzhu Zhao, Kazuhiko Horigome, Megumi Nishio, Yasue Okanishi, Sanae Nagata, Shingo Komura, Yasuhiro Yamada, Junya Toguchida, Akira Ohta, Makoto Ikeya
Publikováno v:
Stem Cell Reports, Vol 11, Iss 5, Pp 1106-1119 (2018)
Summary: Fibrodysplasia ossificans progressiva (FOP) is a rare and intractable disorder characterized by extraskeletal bone formation through endochondral ossification. FOP patients harbor gain-of-function mutations in ACVR1 (FOP-ACVR1), a type I rec
Externí odkaz:
https://doaj.org/article/6fad6a02adfe4b8eb25a135199479482
Autor:
Takayuki Kondo, Keiko Imamura, Misato Funayama, Kayoko Tsukita, Michiyo Miyake, Akira Ohta, Knut Woltjen, Masato Nakagawa, Takashi Asada, Tetsuaki Arai, Shinobu Kawakatsu, Yuishin Izumi, Ryuji Kaji, Nobuhisa Iwata, Haruhisa Inoue
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2304-2312 (2017)
In the process of drug development, in vitro studies do not always adequately predict human-specific drug responsiveness in clinical trials. Here, we applied the advantage of human iPSC-derived neurons, which offer human-specific drug responsiveness,
Externí odkaz:
https://doaj.org/article/119fc43eb23c46f4bc742a11a0c112de
Publikováno v:
Stem Cell Research, Vol 24, Iss C, Pp 61-68 (2017)
While pancreatic islet transplantation achieves insulin independence in type 1 diabetes (T1D) patients, its widespread application is limited by donor tissue scarcity. Pancreatic progenitor cells (PPCs) give rise to all cell types in the pancreas dur
Externí odkaz:
https://doaj.org/article/a43bb141675744d4b06a3b0ac06b8ef1