Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Akira, Kaieda"'
Autor:
Keiko Uga, Jonathan Gilley, Xiuna Yang, Takashi Hoshino, Michael P. Coleman, Robert Adalbert, Mahindra Makhija, Christina Antoniou, Akira Kaieda, Andrea Loreto
Publikováno v:
ACS Chem Neurosci
Disruption of axonal transport causes a number of rare, inherited axonopathies and is heavily implicated in a wide range of more common neurodegenerative disorders, many of them age-related. Acetylation of α-tubulin is one important regulatory mecha
Autor:
Fukuda Hiromi, Weston Lane, Shinichiro Matsunaga, Masayuki Gotoh, Tomohiro Kawamoto, Masashi Takahashi, Seiji Miwatashi, Sachiko Itono, Rei Okamoto, Satoko Unno, Kengo Okada, Takahiro Miyazaki, Toshimasa Tanaka, Hiroshi Sugimoto, Kumar Singh Saikatendu, Akira Kaieda, Yuri Hori, Terufumi Takagi, Shinji Morimoto, Bi-Ching Sang
Publikováno v:
ChemMedChem. 14:2093-2101
We identified novel potent inhibitors of p38 mitogen-activated protein (MAP) kinase using a structure-based design strategy, beginning with lead compound, 3-(butan-2-yl)-6-(2,4-difluoroanilino)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one (1). To enhan
Autor:
Akiko Oki, Katsunori Sasa, Hiroyuki Takada, Bunnai Saito, Kazumasa Miyamoto, Tomoko Nagino, Hidetoshi Sakurai, Ryuichi Tozawa, Tatsuo Oikawa, Makoto Miyamoto, Yuko Kokubu, Michiko Tawada, Tomoya Sameshima, Akira Kaieda
Publikováno v:
Journal of Medicinal Chemistry. 62:9175-9187
Dysferlinopathies, which are muscular diseases caused by mutations in the dysferlin gene, remain serious medical problems due to the lack of therapeutic agents. Herein, we report the design, synthesis, and structure-activity relationships of a 2,6-di
Autor:
Akira Kaieda, Masashi Takahashi, Hiromi Fukuda, Rei Okamoto, Shinji Morimoto, Masayuki Gotoh, Takahiro Miyazaki, Yuri Hori, Satoko Unno, Tomohiro Kawamoto, Toshimasa Tanaka, Sachiko Itono, Terufumi Takagi, Hiroshi Sugimoto, Kengo Okada, Gyorgy Snell, Ryan Bertsch, Jasmine Nguyen, Bi‐Ching Sang, Seiji Miwatashi
Publikováno v:
ChemMedChem. 14:1022-1030
We identified a lead series of p38 mitogen-activated protein kinase inhibitors using a structure-based design strategy from high-throughput screening of hit compound 1. X-ray crystallography of 1 with the kinase showed an infrequent flip of the pepti
Autor:
Takashi Santou, Masakuni Kori, Jun Terauchi, Kenjiro Sato, Akira Kaieda, Yoshio Yamamoto, Hideyuki Oki, Hiroshi Nara, Haruhiko Kuno, Naoyuki Kanzaki, Osamu Uchikawa, Hideyuki Mototani, Takako Naito
Publikováno v:
Journal of Medicinal Chemistry. 60:608-626
On the basis of a superposition study of X-ray crystal structures of complexes of quinazoline derivative 1 and triazole derivative 2 with matrix metalloproteinase (MMP)-13 catalytic domain, a novel series of fused pyrimidine compounds which possess a
Autor:
Hiroyuki, Takada, Akira, Kaieda, Michiko, Tawada, Tomoko, Nagino, Katsunori, Sasa, Tatsuo, Oikawa, Akiko, Oki, Tomoya, Sameshima, Kazumasa, Miyamoto, Makoto, Miyamoto, Yuko, Kokubu, Ryuichi, Tozawa, Hidetoshi, Sakurai, Bunnai, Saito
Publikováno v:
Journal of medicinal chemistry. 62(20)
Dysferlinopathies, which are muscular diseases caused by mutations in the dysferlin gene, remain serious medical problems due to the lack of therapeutic agents. Herein, we report the design, synthesis, and structure-activity relationships of a 2,6-di
Autor:
Seiji Miwatashi, Takahiro Miyazaki, Yuri Hori, Akira Kaieda, Bi-Ching Sang, Masayuki Goto, Kengo Okada, Masashi Takahashi, Terufumi Takagi, Gyorgy Snell, Tomohiro Kawamoto, Satoko Unno, Osamu Uchikawa, Ken Bragstad, Mikio Shirasaki, Sachiko Itono, Toshimasa Tanaka, Takafumi Takai, Teruki Hamada
Publikováno v:
Bioorganicmedicinal chemistry. 26(3)
We identified novel potent inhibitors of p38 MAP kinase using structure-based design strategy. X-ray crystallography showed that when p38 MAP kinase is complexed with TAK-715 (1) in a co-crystal structure, Phe169 adopts two conformations, where one i
Autor:
Makoto Hibiya, Asami Fujiwara, Yasuhiro Ito, Akira Kaieda, Takashi Ishikawa, Tomoaki Yamashiro, Masahito Toyozaki, Hideomi Fukao, Kaoru Kawai, Masaru Yamamoto, Saori Ishida, Takashi Watanabe
Publikováno v:
Japanese Journal of Extra-Corporeal Technology. 41:11-14
Autor:
Osamu Uchikawa, Akira Kaieda, Jun Terauchi, Haruhiko Kuno, Masakuni Kori, Naoyuki Kanzaki, Kenjiro Sato, Takashi Santou, Hiroshi Nara, Hideyuki Oki
Publikováno v:
Bioorganicmedicinal chemistry. 24(23)
Matrix metalloproteinase-13 (MMP-13), a member of the collagenase family of enzymes, has been implicated to play a key role in the pathology of osteoarthritis. Recently, we have reported the discovery of a series of quinazoline-2-carboxamide based no
Autor:
Miyuki Sugimori, Masahito Toyosaki, Miwa Sakakibara, Kenji Mizawa, Yasuhiro Ito, Takashi Isikawa, Akihiro Yamauchi, Masaru Ihira, Saori Ishida, Koji Watanabe, Akira Kaieda, Makoto Hibiya, Masaru Yamamoto, Yoshinobu Hattori
Publikováno v:
Japanese journal of extra-corporeal technology. 34:87-90