Výsledky vyhledávání - "Akio Torikata"

Microbial Conversion of Milbemycins: Oxidation of Milbemycin A4 and Related Compounds at the C-25 Ethyl Group by Circinella umbellata and Absidia cylindrospora

Autor: Keiko Nakagawa, Akio Torikata, Yoshihisa Tsukamoto, Kazuo Sato

Publikováno v: The Journal of Antibiotics. 48:831-837

Microbial oxidation of milbemycin A4 at the C-25 ethyl group was performed. Milbemycin A4 was converted to 31- and 32-hydroxy derivatives by Circinella umbellata SANK 44272 along with 24- and 30-hydroxy derivatives. Related compounds, 5-ketomilbemyci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23db836dc2f46d67bd7030e8d1a9acd9
https://doi.org/10.7164/antibiotics.48.831

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Structural Elucidation of Aculeximycin. IV. Absolute Structure of Aculeximycin, Belonging to a New Class of Macrolide Antibiotics

Autor: Makoto Suzuki, Noboru Nakayama, Isako Ohama, Akio Torikata, Yoshiko Itezono, Toshiro Shibuya, Tatsuo Haneishi, Ken-ichi Harada, Hideaki Murata, Takaya Ikemoto

Publikováno v: The Journal of Antibiotics. 48:850-862

Aculeximycin (1) produced by Streptosporangium albidum possesses a 30-membered polyhydroxy macrocyclic lactone and five sugars including aculexitriose. We have described the determination of the planar structure of N-diacetylated aculeximycin (2) usi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41054b8905eb29aeb01ce2a94d2b9392
https://doi.org/10.7164/antibiotics.48.850

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Screening method for colony-stimulating factor inducers using a human hone marrow stromal cell line, KM-102

Autor: Isao Kaneko, Hiroko Miyaoka, Akio Torikata, Akio Shiraishi, Masatoshi Inukai, Takafumi Kohama

Publikováno v: The Journal of Antibiotics. 46:1494-1502

A new screening method for inducers of colony-stimulating factors (CSFs) was established using KM-102, a human bone marrow stromal cell line as the producer. In this method, the assay system which uses CSF dependent cell lines is combined with the CS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eeb5e9d5696d07936ebac4bb5e91a88
https://doi.org/10.7164/antibiotics.46.1494

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Biosynthesis of griseolic acids: Incorporation of 13C-labeled compounds into griseolic acid A

Autor: Shunichi Miyakoshi, Shuji Takahashi, Mitsuo Yamazaki, Akio Torikata, Tetsuya Shioiri, Hideyuki Haruyama

Publikováno v: The Journal of Antibiotics. 45:394-399

Biosynthesis of griseolic acids, competitive inhibitors of cyclic nucleotide phosphodiesterase, was investigated with the culture of a producing strain of Streptomyces griseoaurantiacus. 13C-Labeled and 15N-labeled compounds were added into the cultu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078f17a7b1e3b2751c486fbdcc035652
https://doi.org/10.7164/antibiotics.45.394

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Microbial conversion of milbemycins: Hydroxylation of milbemycin A4 and related compounds by Cunninghamella echinulata ATCC 9244

Autor: Shunichi Miyakoshi, Akio Torikata, Yoshihisa Tsukamoto, Keiko Nakagawa, Kazuo Sato

Publikováno v: The Journal of Antibiotics. 44:232-240

Many strains of zygomycetes and actinomycetes were found to convert milbemycin A4 (1a) to 13 beta-hydroxymilbemycin A4 (1b). Among these strains, Cunninghamella echinulata ATCC 9244 had the most efficient 13 beta-hydroxylation ability on milbemycins.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68f3ea3804ecf5e332a5780d54a0f6c
https://doi.org/10.7164/antibiotics.44.232

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Structural elucidation of aculeximycin. III. Planar structure of aculeximycin, belonging to a new class of macrolide antibiotics

Autor: HIDEAKI MURATA, KAZUSHI SUZUKI, TAMAO TABAYASHI, CHIE HATTORI, YUMI TAKADA, KEN-ICHI HARADA, MAKOTO SUZUKI, TAKAYA IKEMOTO, TOSHIRO SMBUYA, TATSUO HANEISHI, AKIO TORIKATA, YOSHIKO IXEZONO, NOBORU NAKAYAMA

Publikováno v: The Journal of antibiotics. 48(8)

The planar structure of aculeximycin (1) produced by Streptosporangium albidum has been determined by spectral methods and chemical degradations such as 1,8-diazabicyclo[5,4,0]undec-7-ene (DBU)-methanol reaction, ozonolysis, and periodative oxidation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71c851fb617c867cfdd7240d7b1f061
https://pubmed.ncbi.nlm.nih.gov/7592030

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