Zobrazeno 1 - 10
of 207
pro vyhledávání: '"Akio Toh-E"'
Autor:
Bethany Grace Bowring, Pooja Sethiya, Desmarini Desmarini, Sophie Lev, Lisa Tran Le, Yong-Sun Bahn, Seung-Heon Lee, Akio Toh-e, Nicholas Proschogo, Tom Savage, Julianne Teresa Djordjevic
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT Fungal pathogens uniquely regulate phosphate homeostasis via the cyclin-dependent kinase (CDK) signaling machinery of the phosphate acquisition (PHO) pathway (Pho85 kinase-Pho80 cyclin-CDK inhibitor Pho81), providing drug-targeting opportuni
Externí odkaz:
https://doaj.org/article/d5ca8be315354e79bcf60f2bea130499
Publikováno v:
PLoS Biology, Vol 6, Iss 12, Pp 2817-2830 (2008)
The budding yeast Saccharomyces cerevisiae alters its gene expression profile in response to a change in nutrient availability. The PHO system is a well-studied case in the transcriptional regulation responding to nutritional changes in which a set o
Externí odkaz:
https://doaj.org/article/fb383ef7041c40a7b26aeaa7845f383a
Autor:
Noor Fatin Omar, Susumu Kajiwara, Akio Toh-e, Tria Widiasih Widiyanto, Setyowati Triastuti Utami, Masakazu Niimi, Kyoko Niimi
Publikováno v:
The Journal of General and Applied Microbiology. 67:195-206
We clarified the roles of VPH1 in Cryptococcus neoformans serotype D by examining the detailed phenotypes of VPH1-deficient cells (Δvph1) in terms of their capability to grow in acidic and alkaline pH, at a high temperature, and under high osmotic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf9a4ba5c54e6c088a807998a1e6456f
https://doi.org/10.2323/jgam.2021.02.001
https://doi.org/10.2323/jgam.2021.02.001
Autor:
Kiminori Shimizu, Akio Toh-e, Katsuhiko Kamei, Phuong Thao Nguyen, Akira Watanabe, Yumi Imanishi-Shimizu, Ngoc Hung Nguyen
Publikováno v:
Current Genetics. 67:115-128
The amino acid biosynthetic pathway of invasive pathogenic fungi has been studied as a potential antifungal drug target. Studies of the disruption of genes involved in amino acid biosynthesis have demonstrated the importance of this pathway in the vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b3cbeadc1dc39eee58513ad081b0503
https://doi.org/10.1007/s00294-020-01112-9
https://doi.org/10.1007/s00294-020-01112-9
Publikováno v:
Current genetics. 68(1)
Cryptococcus neoformans, basidiomycetous pathogenic yeast, is basically an environmental fungus and, therefore, challenged by ever changing environments. In this study, we focused on how C. neoformans responds to stress caused by cadmium that is one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a4dc1b25474ea013e7cae698f106f6
https://pubmed.ncbi.nlm.nih.gov/34761291
https://pubmed.ncbi.nlm.nih.gov/34761291
Autor:
Phuong-Thao, Nguyen, Akio, Toh-E, Ngoc-Hung, Nguyen, Yumi, Imanishi-Shimizu, Akira, Watanabe, Katsuhiko, Kamei, Kiminori, Shimizu
Publikováno v:
Current genetics. 67(1)
The amino acid biosynthetic pathway of invasive pathogenic fungi has been studied as a potential antifungal drug target. Studies of the disruption of genes involved in amino acid biosynthesis have demonstrated the importance of this pathway in the vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::67f0f5509c141feb024de7c2ff6f2dbd
https://pubmed.ncbi.nlm.nih.gov/33001274
https://pubmed.ncbi.nlm.nih.gov/33001274
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
In most sexual eukaryotes, mitochondrial (mt) DNA is uniparentally inherited, although the detailed mechanisms underlying this phenomenon remain controversial. The most widely accepted explanations include the autophagic elimination of paternal mitoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f4a578b39e4dfe9a500c60de2d49f7e
http://europepmc.org/articles/PMC7016115
http://europepmc.org/articles/PMC7016115
Autor:
Kiminori Shimizu, Misako Ohkusu, Akio Toh-e, Katsuhiko Kamei, Masashi Yamaguchi, Akira Watanabe, Naruhiko Ishiwada
Publikováno v:
Current Genetics. 63:1093-1104
We constructed deletion mutants of Cryptococcus neoformans var neoformans (serotype D) genes encoding late ergosterol biosynthetic pathway enzymes and found that the mutations enhanced susceptibility to various drugs including micafungin, one of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fbdd65caf322765b98c9fff07b032fa
https://doi.org/10.1007/s00294-017-0713-8
https://doi.org/10.1007/s00294-017-0713-8
Autor:
Kiminori Shimizu, Akio Toh-e, Naruhiko Ishiwada, Azusa Takahashi-Nakaguchi, Misako Ohkusu, Katsuhiko Kamei, Akira Watanabe, Susumu Kawamoto
Publikováno v:
Current Genetics. 63:697-707
It is well known that 5-fluoroorotic acid (5-FOA)-resistant mutants isolated from wild-type Cryptococcus neoformans are exclusively either ura3 or ura5 mutants. Unexpectedly, many of the 5-FOA-resistant mutants isolated in our selective regime were U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c893ddfdb6e9e8423251a215917e88
https://doi.org/10.1007/s00294-016-0672-5
https://doi.org/10.1007/s00294-016-0672-5
Autor:
Naruhiko Ishiwada, Akio Toh-e, Akira Watanabe, Kiminori Shimizu, Misako Ohkusu, Katsuhiko Kamei
Publikováno v:
Current genetics. 64(3)
We elucidated a unique feature of sulfur metabolism in Cryptococcus neoformans. C. neoformans produces cysteine solely by the O-acetylserine pathway that consists of serine-O-acetyl transferase and cysteine synthase. We designated the gene encoding t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b819bf2a39cbd8cef725982523936a95
https://pubmed.ncbi.nlm.nih.gov/29159425
https://pubmed.ncbi.nlm.nih.gov/29159425