Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Akio Kinoshita"'
Autor:
Munehito Ideishi, Emiko Tsuji, Akio Kinoshita, Takaaki Sakai, Kikuo Arakawa, Manabu Sasaguri, Hirokazu Maeda, Keita Noda, Manabu Koga
Publikováno v:
Hypertension Research. 23:511-519
We have previously shown that both renal dopamine (DA) and kallikrein-kinin systems are activated by exercise in mild hypertensives. We aimed to confirm the effects of exercise on the renal DA system and the stimulatory effects of DA on the renal kal
Autor:
Akio Kinoshita, Kikuo Arakawa, Keita Noda, Emiko Tsuji, Shigenori Ogata, Munehito Ideishi, Manabu Sasaguri, Manabu Koga
Publikováno v:
Immunopharmacology. 44:15-19
We previously purified a kallikrein-like enzyme from the dog heart and demonstrated that it is not only able to form kinins but can also convert angiotensin (Ang) I to Ang II. The aim of the present study was to clarify the structure and tissue local
Autor:
Masahiro Kikuchi, Junji Suzumiya, Munehito Ideishi, Hidenori Urata, Kikuo Arakawa, Manabu Sasaguri, Akio Kinoshita, Makoto Ihara
Publikováno v:
Hypertension. 33:1399-1405
Abstract —Locally formed angiotensin II (Ang II) and mast cells may participate in the development of atherosclerosis. Chymase, which originates from mast cells, is the major Ang II–forming enzyme in the human heart and aorta in vitro. The aim of
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 727:219-225
A simple and rapid analytical method for carbapenems using high-performance capillary electrophoresis is described. All therapeutic carbapenem injections in Japan (imipenem, panipenem and meropenem) and four other beta-lactams (piperacillin, cefotiam
Publikováno v:
Hypertension. 32:514-520
Abstract —Angiotensin (Ang) II plays an important role in cardiovascular homeostasis, not only in the systemic circulation but also at the tissue level, and is involved in the remodeling of the heart and vasculature under pathological conditions. A
Autor:
Manabu Sasaguri, E Tashiro, Manabu Koga, Kikuo Arakawa, Shin-ichiro Miura, Munehito Ideishi, Akio Kinoshita
Publikováno v:
Journal of Human Hypertension. 12:455-461
To clarify the ability of clinical and laboratory parameters to reflect target organ damage, especially left ventricular hypertrophy (LVH), we investigated which of these parameters might correlate to LVH as determined by electrocardiographic voltage
Autor:
Shigenori Ogata, Hirokazu Maeda, Manabu Sasaguri, Keita Noda, Akio Kinoshita, Kikuo Arakawa, Emiko Tsuji, Munehito Ideishi
Publikováno v:
Journal of Hypertension. 15:675-682
Objective To purify and characterize a kinin-forming enzyme in the dog heart and to examine the ability of this enzyme to generate angiotensin (Ang) II from Ang I. Methods The enzyme was isolated from heart homogenate using a diethylaminoethyl-Sephar
Publikováno v:
Journal of Clinical Investigation. 95:1519-1527
Human chymase is a serine proteinase that converts angiotensin (Ang) I to Ang II independent of angiotensin converting enzyme (ACE) in vitro. The effects of chymase on systemic hemodynamics and left ventricular function in vivo were studied in nine c
Autor:
Kikuo Arakawa, Akio Kinoshita, Akira Kiyonaga, Hidenori Urata, Shin-ichiro Miura, Manabu Koga
Publikováno v:
Hypertension Research. 18:S73-S77
Physical exercise is one of the life-style modifications used for lowering blood pressure. Except for diminished norepinephrine spill over, the mechanism by which physical exercise exerts its effects was not known. Based on our preliminary finding th
Publikováno v:
Applied Surface Science. :742-744
Chemical analysis of the element and organic substance at the site of pathological changes due to aging is one of the approaches of cataract research. Time of flight secondary ion mass spectrometry (TOF-SIMS) microscopy is expected to analyze element