Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Akio Kayano"'
Autor:
Farid Benayoud, Masayuki Omori, Yuichi Suzuki, Arani Chanda, Kazunori Wakasugi, Yuzo Watanabe, Akio Kayano, Paschalis Dimopoulos, Yoichi Kita, Kunitoshi Takeda, Toshihiko Kaneko, Mitsuo Nagai, Noboru Yamamoto, Takafumi Motoki, Kazuhiro Yoshizawa, Christopher Neil Farthing, Lily Lu, Matthew J. Schnaderbeck, Khan Afzal, Tasuku Ishida, Huiming Zhang, Mamoru Takaishi, Markus Bracke, Branko Mitasev, Dae-Shik Kim, Francis G. Fang, Adrian Hall
Publikováno v:
Organic Process Research & Development. 26:804-816
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb5e8d3db93d6da5adb84ced4755f7b9
https://doi.org/10.1021/acs.oprd.1c00223
https://doi.org/10.1021/acs.oprd.1c00223
Autor:
Dae-Shik Kim, Kazuhiro Yoshizawa, Branko Mitasev, Schnaderbeck, Matthew, Huiming Zhang, Masayuki Omori, Akio Kayano, Mitsuo Nagai, Kazunori Wakasugi, Yuzo Watanabe, Farid Benayoud, Yuichi Suzuki, Takafumi Motoki, Toshihiko Kaneko, Mamoru Takaishi, Tasuku Ishida, Kunitoshi Takeda, Yoichi Kita, Noboru Yamamoto, Afzal Khan
Publikováno v:
Organic Process Research & Development; 3/18/2022, Vol. 26 Issue 3, p804-816, 13p
Publikováno v:
Organic Process Research & Development. 20:100-104
Potential issues associated with the scale up of a catalytic Nozaki–Hiyama–Kishi reaction and a Cr/Mn-mediated desulfonylation used in eribulin mesylate synthesis were evaluated, and countermeasures were investigated. When stir bar agitation, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27e593761c524606dd4c46f7d0cf2306
https://doi.org/10.1021/acs.oprd.5b00383
https://doi.org/10.1021/acs.oprd.5b00383
Autor:
Hirofumi Kuroda, Teiji Takigawa, Hiroyuki Chiba, Katsuya Tagami, Takashi Fukuyama, Akio Kayano
Publikováno v:
Organic Process Research & Development. 20:503-509
Here we examined the use of continuous flow conditions for the final assembly of eribulin mesylate aimed to avoid cryogenic condition. The diisobutylaluminum hydride reduction of ester 2 to aldehyde 3 and n-butyllithium-mediated coupling of aldehyde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d161487906fe3991af90ce1810c3090
https://doi.org/10.1021/acs.oprd.5b00353
https://doi.org/10.1021/acs.oprd.5b00353
Autor:
Hiroyuki Chiba, Katsuya Tagami, Manabu Kubota, Yuki Komatsu, Akio Kayano, Kazato Inanaga, Takashi Fukuyama
Publikováno v:
Organic Letters. 17:3158-3161
A novel and efficient method for the Cr(II)-mediated desulfonylation of α-sulfonyl ketone by a Cr-ligand-Mn system has been developed during the course of process research on Halaven (eribulin mesylate). This reaction is dramatically accelerated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a582aeeb74472dbb57952c79645f38
https://doi.org/10.1021/acs.orglett.5b01497
https://doi.org/10.1021/acs.orglett.5b01497
Autor:
Yongbo Hu, James Cutter, Naoki Asai, Taichi Abe, Hyeong-Wook Choi, Teiji Takigawa, Taiju Nakamura, Thomas Noland, Masanori Mizuno, Atsushi Endo, Marc Pesant, Michael D. Lewis, Takao Omae, Bryan M. Lewis, Kazuhiro Yoshizawa, Francis G. Fang, Tomohiro Watanabe, Shawn McKenna, William J. Christ, Naoki Ozeki, Brian Austad, Gordon D. Wilkie, Hirofumi Kuroda, Trevor Lee Calkins, Manabu Kubota, Akio Kayano, Yumi Asai, John D. Orr, Matthew J. Schnaderbeck, Farid Benayoud, Yuki Komatsu, Robert Costanzo, Silvio Campagna, Taeko Suzuki, Charles E. Chase, Yuichi Kimoto
Publikováno v:
Synlett. 24:327-332
Multikilogram manufacturing process of the Halaven® C14–C35 fragment is described. The synthesis features convergent assembly of subunits by iterative asymmetric Ni/Cr-mediated coupling executed in fixed equipment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c0b6f0e62a97eb1ab238ef7f2117e0
https://doi.org/10.1055/s-0032-1317920
https://doi.org/10.1055/s-0032-1317920
Autor:
Hirofumi Kuroda, Huiming Zhang, Yuki Komatsu, Naoki Asakawa, Yongbo Hu, Akio Kayano, Takashi Hasebe, Takashi Kajima, Xiang Niu, Yorihisa Hoshino, Charles E. Chase, Francis G. Fang, Tomohiro Watanabe, Hiroyuki Ishizuka, Thomas Noland, Matthew J. Schnaderbeck, Thomas E. Horstmann, Naoki Asai, Mamoru Miyazawa, Katsuya Tagami, Brian Austad, Manabu Kubota, John D. Orr, Trevor Lee Calkins, Hiroyuki Chiba, Bryan M. Lewis
Publikováno v:
Synlett. 24:333-337
The evolution of the synthesis of Halaven® (E7389, INN eribulin mesylate) from a medicinal chemistry process to the execution of the final process on pilot scale is described. The completion of the synthesis of Halaven® from C1–C13 ester and C14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd614ef0861f50badf9f4d38d2284d9
https://doi.org/10.1055/s-0032-1318026
https://doi.org/10.1055/s-0032-1318026
Autor:
Joseph Carpenter, Robert R. Knowles, Simon B. Blakey, Ian Mangion, Akio Kayano, Christopher J. Sinz, David W. C. MacMillan
Publikováno v:
Chem. Sci.. 2:308-311
A total synthesis of the marine natural product diazonamide A (1) has been accomplished. This work features a highly stereoselective synthesis of the C(10) quaternary center and the central furanoindoline core enabled by an iminium-catalyzed alkylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e5fbf8dad75fdee6522aca9f7edd09
https://doi.org/10.1039/c0sc00577k
https://doi.org/10.1039/c0sc00577k
Publikováno v:
Tetrahedron Letters. 40:2537-2540
Irradiation of aliphatic and aromatic aldehydes in the presence of benzophenone produces the corresponding acyl radicals which add to 3-hydroxy-1-(methylthio)-1-( p -tolylsulfonyl)-1-alkenes and their acetates with high syn selectivity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f71f70cd248d7e7ece223e349e04327
https://doi.org/10.1016/s0040-4039(99)00196-3
https://doi.org/10.1016/s0040-4039(99)00196-3
Publikováno v:
Tetrahedron Letters. 39:9051-9054
On irradiation (>290 nm) in the absence or presence of benzophenone, various aromatic aldehydes add to ketene dithioacetal S,S-dioxides to give the corresponding 1:1 adducts, which were shown to be synthetic precursors of indanone derivatives.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f2c72ad7142095e843e18848aaa4147
https://doi.org/10.1016/s0040-4039(98)02052-8
https://doi.org/10.1016/s0040-4039(98)02052-8