Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Akio Hakamata"'
Autor:
Eiko Nagata, Yasuharu Kashiwagura, Eisaku Okada, Shimako Tanaka, Shinichiro Sano, Mitsuhiro Nishida, Satoshi Hayano, Satoru Iwashima, Akio Hakamata, Keiichi Odagiri, Naoki Inui, Hiroshi Watanabe, Kazuo Umemura, Shinya Uchida
Publikováno v:
Journal of Pharmacological Sciences, Vol 149, Iss 2, Pp 60-65 (2022)
Infantile hemangioma (IH) is a common tumor in infants that gradually resolves and is often untreated. However, for cosmetic reasons, parents often opt for treatment. Oral propranolol, the first-line therapy for IH, is sometimes associated with sever
Externí odkaz:
https://doaj.org/article/404d9011c9ce4387ba110666ea8d50c3
Autor:
Takashi K. Ito, Tomohito Sato, Akio Hakamata, Yuki Onoda, Shumpei Sato, Fumiyoshi Yamazaki, Makoto Horikawa, Yutaka Takahashi, Takuya Kitamoto, Masako Suzuki, Shinya Uchida, Keiichi Odagiri, Mitsutoshi Setou
Publikováno v:
Translational Medicine of Aging, Vol 4, Iss , Pp 45-54 (2020)
A decrease in nicotinamide adenine dinucleotide (NAD+) levels is a hallmark of aging in multiple organisms, including humans. We report a human clinical trial designed to assess the efficacy of single-dose supplementation of nicotinamide, a form of v
Externí odkaz:
https://doaj.org/article/f4fdfd2190064feea97ad4bed3f1f17e
Autor:
Chiaki Kamiya, Naoki Inui, Akio Hakamata, Sachiko Miyakawa, Shimako Tanaka, Shinya Uchida, Noriyuki Namiki, Keiichi Odagiri, Hiroshi Watanabe
Publikováno v:
Journal of Pharmacological Sciences, Vol 139, Iss 4, Pp 361-366 (2019)
Polymorphisms of cytochrome P450 (CYP) enzymes can affect enzymatic activity, drug metabolism and drug interactions. Although the potential for drug interactions is especially important when co-administering drugs with strong inductive or inhibitory
Externí odkaz:
https://doaj.org/article/fbb21a96967e4a8ea774ffbe3fc27bc9
Autor:
Shinpei Kato, Naoki Inui, Akio Hakamata, Yuzo Suzuki, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Hiroshi Watanabe, Takafumi Suda
Publikováno v:
Respiratory Research, Vol 19, Iss 1, Pp 1-12 (2018)
Abstract Background Pulmonary fibrosis is a progressive and lethal disease characterized by damage to the lung parenchyma with excess extracellular matrix deposition. The involvement of endothelial cells in fibrosis development is unclear. Methods We
Externí odkaz:
https://doaj.org/article/6086ba14c3164caa83f4c47b2a97471c
Autor:
Sayuri Kawamoto, Shimako Tanaka, Motoyasu Miura, Yasuharu Kashiwagura, Chiaki Kamiya, Akio Hakamata, Keiichi Odagiri, Naoki Inui, Hiroshi Watanabe, Noriyuki Namiki, Shinya Uchida
Publikováno v:
Chemical and Pharmaceutical Bulletin. 71:441-446
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb9377c66946a5e397f8df721ddc4279
https://doi.org/10.1248/cpb.c23-00102
https://doi.org/10.1248/cpb.c23-00102
Publikováno v:
Molecular Biology Reports. 48(7):5503-5511
Background Although high doses of proton pump inhibitors can elicit an anticancer effect, this strategy may impair vascular biology. In particular, their effects on endothelial Ca2⁺ signaling and production of endothelium-derived relaxing factor (E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6d0999e20ecabcc6dda85474f9c5f1
http://hdl.handle.net/10271/00004367
http://hdl.handle.net/10271/00004367
Autor:
Yasuharu Kashiwagura, Akio Hakamata, Masami Shirai, Akira Endoh, Shimako Tanaka, Naoki Inui, Hiroshi Watanabe, Noriyuki Namiki, Shinya Uchida
Publikováno v:
Chemicalpharmaceutical bulletin. 70(4)
Propranolol is used as the first-line treatment for infantile hemangiomas (IHs). As oral formulations can cause systemic adverse drug reactions (ADRs), we prepared topical propranolol formulations and evaluated their pharmaceutical profiles. We also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146c4fb235f6112b051c18d3f360a2db
https://pubmed.ncbi.nlm.nih.gov/35370204
https://pubmed.ncbi.nlm.nih.gov/35370204
Autor:
Hiroshi Watanabe, Koichiro Tatsumi, Akio Hakamata, Naoki Katayama, Keiichi Odagiri, Naoki Inui, Noriyuki Namiki, Shimako Tanaka, Shinya Uchida, Chiaki Kamiya
Publikováno v:
British Journal of Clinical Pharmacology. 87:1903-1911
Aims The strong cytochrome P450 (CYP) 2C8 inhibitor gemfibrozil has been demonstrated to increase the area under the plasma concentration-time curve from 0 to infinity (AUC0-∞ ) of ACT-333679, an active metabolite of selexipag, by 11-fold. Similarl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d63929fd8d44cf324c573b0b7cc1b88
https://doi.org/10.1111/bcp.14579
https://doi.org/10.1111/bcp.14579
Autor:
Takuya Kitamoto, Yuki Onoda, Akio Hakamata, Shumpei Sato, Tomohito Sato, Yutaka Takahashi, Fumiyoshi Yamazaki, Mitsutoshi Setou, Masako Suzuki, Shinya Uchida, Makoto Horikawa, Keiichi Odagiri, Takashi K. Ito
Publikováno v:
Translational Medicine of Aging, Vol 4, Iss, Pp 45-54 (2020)
A decrease in nicotinamide adenine dinucleotide (NAD+) levels is a hallmark of aging in multiple organisms, including humans. We report a human clinical trial designed to assess the efficacy of single-dose supplementation of nicotinamide, a form of v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0bd7a19664bacdd834c9b4fe864133
http://www.sciencedirect.com/science/article/pii/S2468501120300043
http://www.sciencedirect.com/science/article/pii/S2468501120300043
Autor:
Kazuo Umemura, Mitsuhiro Nishida, Hiroshi Watanabe, Satoshi Hayano, Akio Hakamata, Eiko Nagata, Satoru Iwashima, Keiichi Odagiri, Shinichiro Sano, Yasuharu Kashiwagura, Shinya Uchida, Naoki Inui, Eisaku Okada, Shimako Tanaka
Infantile hemangioma (IH) is a common tumor in infants that gradually resolves and is often followed up for observation. However, for cosmetic reasons, parents often opt for treatment. Oral propranolol, the first-line therapy for IH, shows several si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc15e746d1938279d9acecea772f9dc9
https://doi.org/10.21203/rs.3.rs-701185/v1
https://doi.org/10.21203/rs.3.rs-701185/v1
