Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Akio Hakamata"'
Autor:
Eiko Nagata, Yasuharu Kashiwagura, Eisaku Okada, Shimako Tanaka, Shinichiro Sano, Mitsuhiro Nishida, Satoshi Hayano, Satoru Iwashima, Akio Hakamata, Keiichi Odagiri, Naoki Inui, Hiroshi Watanabe, Kazuo Umemura, Shinya Uchida
Publikováno v:
Journal of Pharmacological Sciences, Vol 149, Iss 2, Pp 60-65 (2022)
Infantile hemangioma (IH) is a common tumor in infants that gradually resolves and is often untreated. However, for cosmetic reasons, parents often opt for treatment. Oral propranolol, the first-line therapy for IH, is sometimes associated with sever
Externí odkaz:
https://doaj.org/article/404d9011c9ce4387ba110666ea8d50c3
Autor:
Takashi K. Ito, Tomohito Sato, Akio Hakamata, Yuki Onoda, Shumpei Sato, Fumiyoshi Yamazaki, Makoto Horikawa, Yutaka Takahashi, Takuya Kitamoto, Masako Suzuki, Shinya Uchida, Keiichi Odagiri, Mitsutoshi Setou
Publikováno v:
Translational Medicine of Aging, Vol 4, Iss , Pp 45-54 (2020)
A decrease in nicotinamide adenine dinucleotide (NAD+) levels is a hallmark of aging in multiple organisms, including humans. We report a human clinical trial designed to assess the efficacy of single-dose supplementation of nicotinamide, a form of v
Externí odkaz:
https://doaj.org/article/f4fdfd2190064feea97ad4bed3f1f17e
Autor:
Chiaki Kamiya, Naoki Inui, Akio Hakamata, Sachiko Miyakawa, Shimako Tanaka, Shinya Uchida, Noriyuki Namiki, Keiichi Odagiri, Hiroshi Watanabe
Publikováno v:
Journal of Pharmacological Sciences, Vol 139, Iss 4, Pp 361-366 (2019)
Polymorphisms of cytochrome P450 (CYP) enzymes can affect enzymatic activity, drug metabolism and drug interactions. Although the potential for drug interactions is especially important when co-administering drugs with strong inductive or inhibitory
Externí odkaz:
https://doaj.org/article/fbb21a96967e4a8ea774ffbe3fc27bc9
Autor:
Sayuri Kawamoto, Shimako Tanaka, Motoyasu Miura, Yasuharu Kashiwagura, Chiaki Kamiya, Akio Hakamata, Keiichi Odagiri, Naoki Inui, Hiroshi Watanabe, Noriyuki Namiki, Shinya Uchida
Publikováno v:
Chemical and Pharmaceutical Bulletin. 71:441-446
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb9377c66946a5e397f8df721ddc4279
https://doi.org/10.1248/cpb.c23-00102
https://doi.org/10.1248/cpb.c23-00102
Autor:
Shinpei Kato, Naoki Inui, Akio Hakamata, Yuzo Suzuki, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Hiroshi Watanabe, Takafumi Suda
Publikováno v:
Respiratory Research, Vol 19, Iss 1, Pp 1-12 (2018)
Abstract Background Pulmonary fibrosis is a progressive and lethal disease characterized by damage to the lung parenchyma with excess extracellular matrix deposition. The involvement of endothelial cells in fibrosis development is unclear. Methods We
Externí odkaz:
https://doaj.org/article/6086ba14c3164caa83f4c47b2a97471c
Publikováno v:
Molecular Biology Reports. 48(7):5503-5511
Background Although high doses of proton pump inhibitors can elicit an anticancer effect, this strategy may impair vascular biology. In particular, their effects on endothelial Ca2⁺ signaling and production of endothelium-derived relaxing factor (E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6d0999e20ecabcc6dda85474f9c5f1
http://hdl.handle.net/10271/00004367
http://hdl.handle.net/10271/00004367
Autor:
Hiroshi Watanabe, Koichiro Tatsumi, Akio Hakamata, Naoki Katayama, Keiichi Odagiri, Naoki Inui, Noriyuki Namiki, Shimako Tanaka, Shinya Uchida, Chiaki Kamiya
Publikováno v:
British Journal of Clinical Pharmacology. 87:1903-1911
Aims The strong cytochrome P450 (CYP) 2C8 inhibitor gemfibrozil has been demonstrated to increase the area under the plasma concentration-time curve from 0 to infinity (AUC0-∞ ) of ACT-333679, an active metabolite of selexipag, by 11-fold. Similarl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d63929fd8d44cf324c573b0b7cc1b88
https://doi.org/10.1111/bcp.14579
https://doi.org/10.1111/bcp.14579
Autor:
Yasuharu Kashiwagura, Akio Hakamata, Masami Shirai, Akira Endoh, Shimako Tanaka, Naoki Inui, Hiroshi Watanabe, Noriyuki Namiki, Shinya Uchida
Publikováno v:
Chemicalpharmaceutical bulletin. 70(4)
Propranolol is used as the first-line treatment for infantile hemangiomas (IHs). As oral formulations can cause systemic adverse drug reactions (ADRs), we prepared topical propranolol formulations and evaluated their pharmaceutical profiles. We also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146c4fb235f6112b051c18d3f360a2db
https://pubmed.ncbi.nlm.nih.gov/35370204
https://pubmed.ncbi.nlm.nih.gov/35370204
Autor:
Takuya Kitamoto, Yuki Onoda, Akio Hakamata, Shumpei Sato, Tomohito Sato, Yutaka Takahashi, Fumiyoshi Yamazaki, Mitsutoshi Setou, Masako Suzuki, Shinya Uchida, Makoto Horikawa, Keiichi Odagiri, Takashi K. Ito
Publikováno v:
Translational Medicine of Aging, Vol 4, Iss, Pp 45-54 (2020)
A decrease in nicotinamide adenine dinucleotide (NAD+) levels is a hallmark of aging in multiple organisms, including humans. We report a human clinical trial designed to assess the efficacy of single-dose supplementation of nicotinamide, a form of v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0bd7a19664bacdd834c9b4fe864133
http://www.sciencedirect.com/science/article/pii/S2468501120300043
http://www.sciencedirect.com/science/article/pii/S2468501120300043
Autor:
Shinya Uchida, Chiaki Kamiya, Akio Hakamata, Naoki Inui, Noriyuki Namiki, Mai Sotoyama, Hiroshi Watanabe, Shimako Tanaka, Keiichi Odagiri, Yasuharu Kashiwagura
Publikováno v:
Chemical and Pharmaceutical Bulletin. 67:540-545
Fixed-dose combination (FDC) medicines containing two or more active pharmaceutical ingredients (APIs) in a single dosage form have been reported to improve patient adherence to a greater extent than single dosages of individual components (ICs). Ora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589a1a01fd62c55df21d9e888aca0cfa
https://doi.org/10.1248/cpb.c18-00902
https://doi.org/10.1248/cpb.c18-00902