Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Akio Ejima"'
Autor:
Eiji Kumazawa, Megumi Minami, Hiroyuki Naito, Ryo Atsumi, Satoru Ohsuki, Akio Ejima, Mineko Mochizuki, Kenji Hirotani
Publikováno v:
Chemical and Pharmaceutical Bulletin. 53:153-163
A series of novel 3-[4-phenyl-1-piperazinyl]-1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-1-trans-propenes and related compounds were synthesized and evaluated by their cytotoxic activity against several tumor cell lines in vitro and in vivo antitumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b8809e0ecf6afe63daf7ad77dd7004
https://doi.org/10.1248/cpb.53.153
https://doi.org/10.1248/cpb.53.153
Autor:
Eiji Kumazawa, Satoru Ohsuki, Masamichi Sugimori, Hiroyuki Naito, Ryo Atsumi, Yoshihide Nakamura, Megumi Minami, Akio Ejima, Mineko Ishii, Kenji Hirotani
Publikováno v:
Chemical and Pharmaceutical Bulletin. 50:453-462
A series of novel 3-substituted-1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-1-trans-propenes in order to improve the in vitro and in vivo activity of our prototype 3-[4-(3-chlorophenyl)-1-piperazinyl]-1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-1-trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced28f95c6b07689440796b8f7ab6d51
https://doi.org/10.1248/cpb.50.453
https://doi.org/10.1248/cpb.50.453
Autor:
Keiki Sato, Yasuyoshi Kawato, Hirofumi Terasawa, Y. Hirota, Kouichi Uoto, Satoru Ohsuki, Masamichi Sugimori, Ikuo Mitsui, Akio Ejima
Publikováno v:
Journal of Medicinal Chemistry. 41:2308-2318
Nineteen ring A- and F-modified hexacyclic analogues of camptothecin were synthesized by Friedländer condensation of appropriately substituted bicyclic amino ketones with tricyclic ketone and were evaluated for cytotoxicity and topoisomerase I inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0086e00c4f0cd440a5d654de0cee6be3
https://doi.org/10.1021/jm970765q
https://doi.org/10.1021/jm970765q
Autor:
Masamichi Sugimori, Satoru Ohsuki, Yasuhide Hirota, Eiji Kumazawa, Masashi Aonuma, Kouichi Uoto, Hirofumi Terasawa, Akio Ejima, Ikuo Mitsui, Keiki Sato
Publikováno v:
Japanese Journal of Cancer Research : Gann
CPT‐11, a semisynthetic derivative of camptothecin, exhibited strong antitumor activity against lymphoma, lung cancer, colorectal cancer, gastric cancer, ovarian cancer, and cervical cancer. CPT‐11 is a pro‐drug that is converted to an active m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0deebf591f2521e13b34c6191e4d7992
https://doi.org/10.1111/j.1349-7006.1995.tb02468.x
https://doi.org/10.1111/j.1349-7006.1995.tb02468.x
Autor:
Hiroaki Tagawa, Akio Ejima, Ikuo Mitsui, K Matsumoto, M Yasuoka, Satoru Ohsuki, Masamichi Sugimori, Keiki Sato, Yasuyoshi Kawato, Kouichi Uoto
Publikováno v:
Journal of Medicinal Chemistry. 37:3033-3039
Eleven novel hexacyclic and three 7,9-disubstituted pentacyclic derivatives of camptothecin were synthesized and evaluated for in vitro cytotoxic activity against P388, HOC-21, and QG-56 and in vivo antileukemic activity against P388 in mice. Hexacyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::313d1d7c7e7d812a76dab192bbc37aa7
https://doi.org/10.1021/jm00045a007
https://doi.org/10.1021/jm00045a007
Autor:
Nobuhiro Ishihara, Akio Ejima, Kazuo Uenakai, Kaho Nakagawa, Hiroshi Kuga, Ikuo Mitsui, Fumio Saito, Keiki Sato
Publikováno v:
Journal of the agricultural chemical society of Japan. 67:1411-1416
コーンの水抽出物中から得られたケトール型不飽和脂肪酸の抗腫瘍活性の評価を行い以下の結果を得た. (1) In vitro試験の結果γ-ケトールはリノール酸に比べ5～10倍の活性を示し,抗腫瘍ス
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1ce8e7d57e68402c50ef5fdefcabf3a
https://doi.org/10.1271/nogeikagaku1924.67.1411
https://doi.org/10.1271/nogeikagaku1924.67.1411
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bf960a289a7b5c7fdefdcf50cf761d3
https://doi.org/10.1002/chin.199218318
https://doi.org/10.1002/chin.199218318
Autor:
Hirofumi Terasawa, K Matsumoto, Masamichi Sugimori, Yasuyoshi Kawato, Satoru Ohsuki, Akio Ejima, M Yasuoka, Hiroaki Tagawa
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d7012f6e11234571c05dd4370420049
https://doi.org/10.1002/chin.199425142
https://doi.org/10.1002/chin.199425142
Publikováno v:
ChemInform. 27
A new type of synthetic dual inhibitor of DNA topoisomerase I and II was explored. This series of compounds shows high antineoplastic activities against cancer cells, but in vivo activity against P388 was not as high as in vitro activities.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c6a0d4a6d498f7b57560eeb2be0b6c3
https://doi.org/10.1002/chin.199647118
https://doi.org/10.1002/chin.199647118
Autor:
S. C. Burford, Kenji Hirotani, Tamotsu Miwa, Kei-ichi Kawagoe, Ikuo Mitsui, Eiji Kumazawa, Akio Ejima
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aeb4c8664c16d905a8ae6516bd8edaa
https://doi.org/10.1002/chin.199807129
https://doi.org/10.1002/chin.199807129