Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Akio, Kazusaka"'
Autor:
Akio Kazusaka, Tomoyuki Matsumoto, Nobuo Sasaki, Yoshinori Ikenaka, Mayumi Ishizuka, Shoichi Fujita
Publikováno v:
Pesticide Biochemistry and Physiology. 100:135-139
The nitrofuran antibacterial agent furazolidone (FZ) is still used in veterinary medicine in some countries in the Middle and Far East. The present study aimed to show the effect of FZ on the activity of microsomal enzymes that metabolize FZ, and to
Autor:
Kentaro Q. Sakamoto, Zein Shaban, Shoichi Fujita, Khlood M. El Bohi, Akio Kazusaka, Mayumi Ishizuka, Kaampwe Muzandu
Publikováno v:
Toxicology and Applied Pharmacology. 215:330-340
Peroxynitrite formed by the reaction of superoxide and nitric oxide is a highly reactive species with a role in various pathological processes such as cancer, chronic inflammation, and cardiovascular and neurological diseases. In the present study, t
Publikováno v:
Archives of Toxicology. 81:27-33
Tamoxifen, an estrogen receptor antagonist, has been clinically used as an antitumor drug and induces apoptosis in GH3 pituitary cells. Although di-(2-ethylhexyl) phthalate (DEHP) is a well-known environmental estrogen and the exposure to this chemic
Publikováno v:
Veterinary Research Communications. 30:505-512
CYP2D-related drug metabolism in liver microsomes from animals of the Canoidea super family, i.e. mink (Mustela vison), bears (Ursus arctos), foxes (Vulpes vulpes) and dogs, were investigated. Propranolol, bunitrolol and imipramine, which are typical
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 98(1):48-55
Equilenin is one of 10 kinds of estrogens that are found in pregnant mares' urine. It has been used extensively for estrogen replacement therapy in postmenopausal women. Typical inducers of the cytochrome P4501A1 (CYP1A1), such as TCDD, benzo(a)pyren
Autor:
Hyung-Sub Kim, Akio Kazusaka, Shoichi Fujita, Yoshihiko Funae, Noriaki Sakai, Konomu Saito, Mayumi Ishizuka
Publikováno v:
Drug Metabolism and Disposition. 33:1657-1660
Diazepam was metabolized to three primary metabolites, 3-hydroxy-diazepam, N-desmethyl-diazepam, and p-hydroxy-diazepam. Our previous studies reported metabolic position-specific inter- or intrastrain differences in diazepam metabolism among Sprague-
Publikováno v:
Free Radical Research. 39:389-398
Catechol estrogens (CEs), such as 4-hydroxyestradiol (4-OHE2), undergo redox cycling during which reactive oxygen species (ROS) such as superoxide (O2*-) and the chemically reactive estrogen semiquinone (CE-SQ) and quinone (CE-Q) intermediates are pr
Publikováno v:
Journal of Pharmaceutical Sciences. 93:1271-1278
We observed variations in the metabolism of diazepam in Wistar rats. We studied these variations carefully, and found that the variations are dimorphic and about 17% of male rats of Wistar strain we examined showed two times higher diazepam metabolic
Autor:
Takahiro Aoto, Shoichi Fujita, Aiko Yokoyama, Mayumi Ishizuka, Hitomi Hirose, Kiyotaka Nakai, Kentaro Q. Sakamoto, Akio Kazusaka, Ryoko Ushikoshi
Publikováno v:
Chemosphere. 51:491-500
Accumulations of polychlorinated dibenzo- p -dioxins, dibenzofurans and coplanar polychlorinated biphenyls were analyzed in common carp ( Cyprinus carpio ) collected in the Hikiji River, Kanagawa Prefecture, Japan in which dioxin contaminated effluen
Publikováno v:
International Congress Series. 1233:121-126
In the previous study, we cloned two novel cytochrome P450 (CYP) cDNAs (CYP2D23 and CYP2D24) from a rabbit liver cDNA library. CYP2D23 and CYP2D24 were heterogeneously expressed in 293T cells. CYP2D24 effectively catalyzed the oxidation of bufuralol