Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Akio, Kazusaka"'
Autor:
Akio Kazusaka, Tomoyuki Matsumoto, Nobuo Sasaki, Yoshinori Ikenaka, Mayumi Ishizuka, Shoichi Fujita
Publikováno v:
Pesticide Biochemistry and Physiology. 100:135-139
The nitrofuran antibacterial agent furazolidone (FZ) is still used in veterinary medicine in some countries in the Middle and Far East. The present study aimed to show the effect of FZ on the activity of microsomal enzymes that metabolize FZ, and to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa40d77b66e93a2ecd24142677dcd3e2
https://doi.org/10.1016/j.pestbp.2011.02.013
https://doi.org/10.1016/j.pestbp.2011.02.013
Autor:
Kentaro Q. Sakamoto, Zein Shaban, Shoichi Fujita, Khlood M. El Bohi, Akio Kazusaka, Mayumi Ishizuka, Kaampwe Muzandu
Publikováno v:
Toxicology and Applied Pharmacology. 215:330-340
Peroxynitrite formed by the reaction of superoxide and nitric oxide is a highly reactive species with a role in various pathological processes such as cancer, chronic inflammation, and cardiovascular and neurological diseases. In the present study, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e9f7c6c5ae848f9e6ee204b7c75625
https://doi.org/10.1016/j.taap.2006.03.006
https://doi.org/10.1016/j.taap.2006.03.006
Publikováno v:
Archives of Toxicology. 81:27-33
Tamoxifen, an estrogen receptor antagonist, has been clinically used as an antitumor drug and induces apoptosis in GH3 pituitary cells. Although di-(2-ethylhexyl) phthalate (DEHP) is a well-known environmental estrogen and the exposure to this chemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a72465439fbfda51bcebe7bdec1ff309
https://doi.org/10.1007/s00204-006-0132-y
https://doi.org/10.1007/s00204-006-0132-y
Publikováno v:
Veterinary Research Communications. 30:505-512
CYP2D-related drug metabolism in liver microsomes from animals of the Canoidea super family, i.e. mink (Mustela vison), bears (Ursus arctos), foxes (Vulpes vulpes) and dogs, were investigated. Propranolol, bunitrolol and imipramine, which are typical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::198737ca0f52e7590fd3b30fe33bbe6d
https://doi.org/10.1007/s11259-006-3213-8
https://doi.org/10.1007/s11259-006-3213-8
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 98(1):48-55
Equilenin is one of 10 kinds of estrogens that are found in pregnant mares' urine. It has been used extensively for estrogen replacement therapy in postmenopausal women. Typical inducers of the cytochrome P4501A1 (CYP1A1), such as TCDD, benzo(a)pyren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71d7f67d7a364928a00eec667a1db56
http://hdl.handle.net/2115/5818
http://hdl.handle.net/2115/5818
Autor:
Hyung-Sub Kim, Akio Kazusaka, Shoichi Fujita, Yoshihiko Funae, Noriaki Sakai, Konomu Saito, Mayumi Ishizuka
Publikováno v:
Drug Metabolism and Disposition. 33:1657-1660
Diazepam was metabolized to three primary metabolites, 3-hydroxy-diazepam, N-desmethyl-diazepam, and p-hydroxy-diazepam. Our previous studies reported metabolic position-specific inter- or intrastrain differences in diazepam metabolism among Sprague-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2382f58cbff6b7b016f86cc13d46d4a7
https://doi.org/10.1124/dmd.105.004242
https://doi.org/10.1124/dmd.105.004242
Publikováno v:
Free Radical Research. 39:389-398
Catechol estrogens (CEs), such as 4-hydroxyestradiol (4-OHE2), undergo redox cycling during which reactive oxygen species (ROS) such as superoxide (O2*-) and the chemically reactive estrogen semiquinone (CE-SQ) and quinone (CE-Q) intermediates are pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::115ac600a74c4e753986fea366df0660
https://doi.org/10.1080/10715760400029710
https://doi.org/10.1080/10715760400029710
Publikováno v:
Journal of Pharmaceutical Sciences. 93:1271-1278
We observed variations in the metabolism of diazepam in Wistar rats. We studied these variations carefully, and found that the variations are dimorphic and about 17% of male rats of Wistar strain we examined showed two times higher diazepam metabolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0e5183b87e131ee927bcb6937cc09a
https://doi.org/10.1002/jps.20050
https://doi.org/10.1002/jps.20050
Autor:
Takahiro Aoto, Shoichi Fujita, Aiko Yokoyama, Mayumi Ishizuka, Hitomi Hirose, Kiyotaka Nakai, Kentaro Q. Sakamoto, Akio Kazusaka, Ryoko Ushikoshi
Publikováno v:
Chemosphere. 51:491-500
Accumulations of polychlorinated dibenzo- p -dioxins, dibenzofurans and coplanar polychlorinated biphenyls were analyzed in common carp ( Cyprinus carpio ) collected in the Hikiji River, Kanagawa Prefecture, Japan in which dioxin contaminated effluen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3def8783d183ea2e811bcbc55b1676b6
https://doi.org/10.1016/s0045-6535(03)00005-5
https://doi.org/10.1016/s0045-6535(03)00005-5
Publikováno v:
International Congress Series. 1233:121-126
In the previous study, we cloned two novel cytochrome P450 (CYP) cDNAs (CYP2D23 and CYP2D24) from a rabbit liver cDNA library. CYP2D23 and CYP2D24 were heterogeneously expressed in 293T cells. CYP2D24 effectively catalyzed the oxidation of bufuralol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::278def74e765d9ce712d1eec63c330d3
https://doi.org/10.1016/s0531-5131(02)00287-x
https://doi.org/10.1016/s0531-5131(02)00287-x