Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Akinori Takemura"'
Autor:
Sayaka Deguchi, Tomohiro Shintani, Kazuo Harada, Toru Okamoto, Akinori Takemura, Kazumasa Hirata, Kousei Ito, Kazuo Takayama, Hiroyuki Mizuguchi
Publikováno v:
Hepatology Communications, Vol 5, Iss 8, Pp 1385-1399 (2021)
In drug development, a system for predicting drug metabolism and drug‐induced toxicity is necessary to ensure drug safety. Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) is an important drug‐metabolizing enzyme expressed in the liver and
Externí odkaz:
https://doaj.org/article/0dcd03a6c47942ae95c34c3c10e76bf5
Publikováno v:
Journal of Toxicological Sciences. 2023, Vol. 48 Issue 2, p65-73. 9p.
Publikováno v:
Toxicology Research. 12:86-94
Drug-induced liver injury (DILI) is a major factor influencing new drug withdrawal; therefore, an appropriate toxicity assessment at the preclinical stage is required. Previous in silico models have been established using compound information listed
Autor:
Chika Yamamoto1, Akinori Takemura1, Sanae Ishii1, Atsushi Doi2, Isao Saito2, Hideki Yamada2, Yoko Sakai3, Tamihide Matsunaga3, Kousei Ito1 itokousei@chiba-u.jp
Publikováno v:
Journal of Toxicological Sciences. Jan2022, Vol. 47 Issue 1, p13-18. 6p.
Autor:
Akinori, Takemura, Kousei, Ito
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2544
Inhibition of bile acid excretion by drugs is a significant factor in the development of drug-induced cholestatic liver injury. We constructed a new in vitro assay system to detect bile acid-dependent cytotoxicity in hepatocytes. This cell-based syst
Autor:
Hiroyuki Mizuguchi, Kousei Ito, Tomohiro Shintani, Kazuo Harada, Akinori Takemura, Sayaka Deguchi, Kazuo Takayama, Kazumasa Hirata, Toru Okamoto
Publikováno v:
Hepatology Communications
Hepatology Communications, Vol 5, Iss 8, Pp 1385-1399 (2021)
Hepatology Communications, Vol 5, Iss 8, Pp 1385-1399 (2021)
In drug development, a system for predicting drug metabolism and drug‐induced toxicity is necessary to ensure drug safety. Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) is an important drug‐metabolizing enzyme expressed in the liver and
Publikováno v:
Drug Metabolism and Pharmacokinetics. :100511
Autor:
Akinori Takemura, Kousei Ito
Publikováno v:
Methods in Molecular Biology ISBN: 9781071625569
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::517a36f2497df0c62e81f04be38dd456
https://doi.org/10.1007/978-1-0716-2557-6_8
https://doi.org/10.1007/978-1-0716-2557-6_8
Autor:
Kousei Ito, Yoko Sakai, Takahiro Iwao, Shuichi Sekine, Tamihide Matsunaga, Akinori Takemura, Takeshi Susukida, Takumi Nukaga
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:264-271
Cholestatic drug-induced liver injury (DILI) is a type of hepatotoxicity. Its underlying mechanisms are dysfunction of bile salt export pump (BSEP) and multidrug resistance-associated protein 2/3/4 (MRP2/3/4), which play major roles in bile acid (BA)
Autor:
Haruyo Aoyagi, Shuichi Sekine, Hideki Aizaki, Ayako Mimata, Tomoyuki Sato, Yuriko Sakamaki, Kousei Ito, Akinori Takemura, Yugo Ikeyama
Publikováno v:
Fundamental Toxicological Sciences. 6:281-286