Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Akinori Kawakami"'
Autor:
Elisabeth Roider, Alexandra I. T. Lakatos, Alicia M. McConnell, Poguang Wang, Alina Mueller, Akinori Kawakami, Jennifer Tsoi, Botond L. Szabolcs, Anna A. Ascsillán, Yusuke Suita, Vivien Igras, Jennifer A. Lo, Jennifer J. Hsiao, Rebecca Lapides, Dorottya M. P. Pál, Anna S. Lengyel, Alexander Navarini, Arimichi Okazaki, Othon Iliopoulos, István Németh, Thomas G. Graeber, Leonard Zon, Roger W. Giese, Lajos V. Kemeny, David E. Fisher
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Microphthalmia-associated transcription factor (MITF) is a master regulator of melanocyte function, development and plays a significant role in melanoma pathogenesis. MITF genomic amplification promotes melanoma development, and it can facil
Externí odkaz:
https://doaj.org/article/cc94d2d3111647cfb25391c16c6a03e3
Autor:
Tokimasa Hida, Takafumi Kamiya, Akinori Kawakami, Jiro Ogino, Hitoshi Sohma, Hisashi Uhara, Kowichi Jimbow
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 17, p 6129 (2020)
Melanogenesis is the biological and biochemical process of melanin and melanosome biosynthesis. Melanin is formed by enzymic reactions of tyrosinase family proteins that convert tyrosine to form brown-black eumelanin and yellow-red pheomelanin within
Externí odkaz:
https://doaj.org/article/f368276352d74b60b5f93316842c3740
Autor:
Zaizhou Liu, Kaige Chen, Jun Dai, Peng Xu, Wei Sun, Wanlin Liu, Zhixin Zhao, Steven P. Bennett, Peifeng Li, Tiancheng Ma, Yuqi Lin, Akinori Kawakami, Jing Yu, Fei Wang, Chunxi Wang, Miao Li, Peter Chase, Peter Hodder, Timothy P. Spicer, Louis Scampavia, Chunyang Cao, Lifeng Pan, Jiajia Dong, Yong Chen, Biao Yu, Min Guo, Pengfei Fang, David E. Fisher, Jing Wang
Publikováno v:
Cell Research. 33:55-70
Microphthalmia transcription factor (MITF) regulates melanocyte development and is the "lineage-specific survival" oncogene of melanoma. MITF is essential for melanoma initiation, progression, and relapse and has been considered an important therapeu
Autor:
David E. Fisher, Jun S. Song, Wooyoung M. Moon, Jeffrey B. Cheng, Miroslav Hejna, Akinori Kawakami
Publikováno v:
Pigment Cell & Melanoma Research. 32:500-509
MITF and MYC are well-known oncoproteins and members of the basic helix-loop-helix leucine zipper (bHLH-Zip) family of transcription factors (TFs) recognizing hexamer E-box motifs. MITF and MYC not only share the core binding motif, but are also the
Autor:
Hisashi Uhara, Hitoshi Sohma, Tokimasa Hida, Akinori Kawakami, Takafumi Kamiya, Kowichi Jimbow, Jiro Ogino
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 6129, p 6129 (2020)
International Journal of Molecular Sciences, Vol 21, Iss 6129, p 6129 (2020)
Melanogenesis is the biological and biochemical process of melanin and melanosome biosynthesis. Melanin is formed by enzymic reactions of tyrosinase family proteins that convert tyrosine to form brown-black eumelanin and yellow-red pheomelanin within
Autor:
Qiong Shen, William C. Forrester, Philipp Krastel, David E. Fisher, Jessi Ambrose, Daniel K. Nomura, Jeremy L. Jenkins, Nathan T. Ross, Lydia H. Zhang, Marc Hild, Akinori Kawakami, Hyelim Cho, Amanda Cobos-Correa, Fabian K. Eggimann, Howard R Miller, Scott Gleim, Frederic Sigoillot, John A. Tallarico, Charles Moore, Philippe Piechon, Ying Wang, Mikiko Okumura, Peter Aspesi, Felipa A. Mapa, Burks Heather Elizabeth, Thomas J. Maimone, Stephen M. Canham, Guglielmo Roma
Publikováno v:
Cell Chemical Biology. 28:1407-1419.e6
Three limonoid natural products with selective anti-proliferative activity against BRAF(V600E) and NRAS(Q61K)-mutation-dependent melanoma cell lines were identified. Differential transcriptome analysis revealed dependency of compound activity on expr
Autor:
Jennifer J. Hsiao, Ju Hee Lee, Hequn Wang, Francisco Rothhammer, Conor L. Evans, Kazumasa Wakamatsu, Vivien Igras, David E. Fisher, Alicia M. McConnell, Jianming Zhang, Paula P. Navarro, Maria Vittoria Schiaffino, Luba M. Pardo, Gabriel Bedoya, Kathleen A. Christie, Antonio Cozzio, Tamar Nijsten, Thomas Ruzicka, Victor Acuna-Alonso, Giovanni Poletti, Luke H. Chao, Carla Gallo, Kaspar Itin, Othon Iliopoulos, Qing Yu Weng, Shosuke Ito, Alexander A. Navarini, Lajos Kemény, Kaustubh Adhikari, Akinori Kawakami, Yusuke Suita, Shaohua Fan, Haley R. Noonan, Nisma Mujahid, Camila Makhlouta Lugo, Elisabeth Roider, Inbal Rachmin, Samuel Canizales-Quinteros, Leonard I. Zon, Maria Cátira Bortolini, Alyssa Lovas, Chong Hyun Won, István Németh, Jennifer A. Lo, Nhu T. Nguyen, Benjamin P. Kleinstiver, Jennifer Allouche, Sarah A. Tishkoff, Carola Berking, Andres Ruiz-Linares, Rolando González-José, Sam Osseiran, Shinichiro Kato
Publikováno v:
Cell, 184(16), 4268-4283.e20. Cell Press
Ultraviolet (UV) light and incompletely understood genetic and epigenetic variations determine skin color. Here we describe an UV- and microphthalmia-associated transcription factor (MITF)-independent mechanism of skin pigmentation. Targeting the mit
The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology
Autor:
David E. Fisher, Akinori Kawakami
Publikováno v:
Laboratory Investigation. 97:649-656
Certain transcription factors have vital roles in lineage development, including specification of cell types and control of differentiation. Microphthalmia-associated transcription factor (MITF) is a key transcription factor for melanocyte developmen