Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Akinori Kanai"'
Autor:
Yasuhiko Haga, Yoshitaka Sakamoto, Keiko Kajiya, Hitomi Kawai, Miho Oka, Noriko Motoi, Masayuki Shirasawa, Masaya Yotsukura, Shun-Ichi Watanabe, Miyuki Arai, Junko Zenkoh, Kouya Shiraishi, Masahide Seki, Akinori Kanai, Yuichi Shiraishi, Yasushi Yatabe, Daisuke Matsubara, Yutaka Suzuki, Masayuki Noguchi, Takashi Kohno, Ayako Suzuki
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The mechanism underlying the development of tumors, particularly at early stages, still remains mostly elusive. Here, we report whole-genome long and short read sequencing analysis of 76 lung cancers, focusing on very early-stage lung adenoc
Externí odkaz:
https://doaj.org/article/04dd43d62a6b41fea8001fa49282ad6a
Autor:
Muran Xiao, Shinji Kondo, Masaki Nomura, Shinichiro Kato, Koutarou Nishimura, Weijia Zang, Yifan Zhang, Tomohiro Akashi, Aaron Viny, Tsukasa Shigehiro, Tomokatsu Ikawa, Hiromi Yamazaki, Miki Fukumoto, Atsushi Tanaka, Yasutaka Hayashi, Yui Koike, Yumi Aoyama, Hiromi Ito, Hiroyoshi Nishikawa, Toshio Kitamura, Akinori Kanai, Akihiko Yokoyama, Tohru Fujiwara, Susumu Goyama, Hideki Noguchi, Stanley C. Lee, Atsushi Toyoda, Kunihiko Hinohara, Omar Abdel-Wahab, Daichi Inoue
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract ATP-dependent chromatin remodeling SWI/SNF complexes exist in three subcomplexes: canonical BAF (cBAF), polybromo BAF (PBAF), and a newly described non-canonical BAF (ncBAF). While cBAF and PBAF regulate fates of multiple cell types, roles f
Externí odkaz:
https://doaj.org/article/693ff5b078c74b6097e1c14e546c55c7
Autor:
Dustin C. Becht, Akinori Kanai, Soumi Biswas, Mohamed Halawa, Lei Zeng, Khan L. Cox, Michael G. Poirier, Ming-Ming Zhou, Xiaobing Shi, Akihiko Yokoyama, Tatiana G. Kutateladze
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109367- (2024)
Summary: Acetylation of histones by lysine acetyltransferases (KATs) provides a fundamental mechanism by which chromatin structure and transcriptional programs are regulated. Here, we describe a dual binding activity of the first winged helix domain
Externí odkaz:
https://doaj.org/article/d253eb29fab6433ca64c40b9bbb935fc
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Altered transcriptional machinery promotes aberrant self-renewal of non-stem hematopoietic progenitors. Here the authors show that AF10 fusion proteins cause aberrant self-renewal via ENL, which promotes leukemic transformation by binding to MOZ/MORF
Externí odkaz:
https://doaj.org/article/f72f4d793c9b4cf798eb39c807bf8faf
Autor:
Dustin C. Becht, Brianna J. Klein, Akinori Kanai, Suk Min Jang, Khan L. Cox, Bing-Rui Zhou, Sabrina K. Phanor, Yi Zhang, Ruo-Wen Chen, Christopher C. Ebmeier, Catherine Lachance, Maxime Galloy, Amelie Fradet-Turcotte, Martha L. Bulyk, Yawen Bai, Michael G. Poirier, Jacques Côté, Akihiko Yokoyama, Tatiana G. Kutateladze
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Human acetyltransferases MOZ and MORF mediate development programs and are dysregulated in diseases. Here the authors identified two winged helix (WH) domains in MORF/MOZ and characterized their DNA binding functions, including targeting of CpG by WH
Externí odkaz:
https://doaj.org/article/a2ad2ef5ddc546e58f71dca700b8f668
Autor:
Gentaro Egusa, Haruya Ohno, Gaku Nagano, Junji Sagawa, Hiroko Shinjo, Yutaro Yamamoto, Natsumi Himeno, Yoshimi Morita, Akinori Kanai, Ryuta Baba, Kazuhiro Kobuke, Kenji Oki, Masayasu Yoneda, Noboru Hattori
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107143- (2023)
Summary: Beige adipocytes are inducible thermogenic adipocytes used for anti-obesity treatment. Beige adipocytes rapidly lose their thermogenic capacity once external cues are removed. However, long-term administration of stimulants, such as PPARγ a
Externí odkaz:
https://doaj.org/article/c677eb3e632c463a8165b73ca7529eeb
Autor:
Tomoya Isobe, Masatoshi Takagi, Aiko Sato-Otsubo, Akira Nishimura, Genta Nagae, Chika Yamagishi, Moe Tamura, Yosuke Tanaka, Shuhei Asada, Reina Takeda, Akiho Tsuchiya, Xiaonan Wang, Kenichi Yoshida, Yasuhito Nannya, Hiroo Ueno, Ryo Akazawa, Itaru Kato, Takashi Mikami, Kentaro Watanabe, Masahiro Sekiguchi, Masafumi Seki, Shunsuke Kimura, Mitsuteru Hiwatari, Motohiro Kato, Shiro Fukuda, Kenji Tatsuno, Shuichi Tsutsumi, Akinori Kanai, Toshiya Inaba, Yusuke Shiozawa, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Rishi S. Kotecha, Mark N. Cruickshank, Fumihiko Ishikawa, Tomohiro Morio, Mariko Eguchi, Takao Deguchi, Nobutaka Kiyokawa, Yuki Arakawa, Katsuyoshi Koh, Yuki Aoki, Takashi Ishihara, Daisuke Tomizawa, Takako Miyamura, Eiichi Ishii, Shuki Mizutani, Nicola K. Wilson, Berthold Göttgens, Satoru Miyano, Toshio Kitamura, Susumu Goyama, Akihiko Yokoyama, Hiroyuki Aburatani, Seishi Ogawa, Junko Takita
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The molecular heterogeneity of KMT2A-rearranged infant acute lymphoblastic leukemia (ALL) remains poorly characterised. Here, the authors perform multi-omics analysis for 84 ALL patients and suggest 5 distinct subgroups for risk stratification and pe
Externí odkaz:
https://doaj.org/article/7fee3de7cd6b4b10b237a1df0b62b1d6
Autor:
Yoshitaka Sakamoto, Shuhei Miyake, Miho Oka, Akinori Kanai, Yosuke Kawai, Satoi Nagasawa, Yuichi Shiraishi, Katsushi Tokunaga, Takashi Kohno, Masahide Seki, Yutaka Suzuki, Ayako Suzuki
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Long-read sequencing technologies are useful for the multifaceted task of characterising somatic mutations, including structural variants, in cancers. Here, the authors combine short and long read sequencing for the phasing analysis, which enables th
Externí odkaz:
https://doaj.org/article/f517305d9bd44c789127c73bfeec27a9
KDM4B promotes acute myeloid leukemia associated with AML1‐ETO by regulating chromatin accessibility
Autor:
Takeshi Ueda, Akinori Kanai, Akiyoshi Komuro, Hisayuki Amano, Kazushige Ota, Masahiko Honda, Masahito Kawazu, Hitoshi Okada
Publikováno v:
FASEB BioAdvances, Vol 3, Iss 12, Pp 1020-1033 (2021)
Abstract Epigenetic alterations of chromatin structure affect chromatin accessibility and collaborate with genetic alterations in the development of cancer. Lysine demethylase 4B (KDM4B) has been identified as a JmjC domain‐containing epigenetic mo
Externí odkaz:
https://doaj.org/article/5926bec7943c4cc888c811f78ca73aa2
Autor:
Yu Hara, Yume Oshima, Yoichi Tagami, Ayako Aoki, Hiroaki Fujii, Ami Izawa, Kenichi Seki, Akinori Kanai, Aya Yabe, Keisuke Watanabe, Nobuyuki Horita, Nobuaki Kobayashi, Takeshi Kaneko
Publikováno v:
Respiratory Medicine Case Reports, Vol 36, Iss , Pp 101615- (2022)
A 70-year-old man diagnosed with idiopathic pulmonary fibrosis (IPF) one year earlier developed progressive exertional dyspnea 3 weeks after onset of coronavirus disease 2019 (COVID-19). High-resolution computed tomography showed new extensive ground
Externí odkaz:
https://doaj.org/article/c2109c943239470caf08b46c5d212b15