Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Akinori Hamaguchi"'
Autor:
Masako Uchii, Mariko Sakai, Yuhei Hotta, Satoshi Saeki, Naoya Kimoto, Akinori Hamaguchi, Tetsuya Kitayama, Shunji Kunori
Publikováno v:
Journal of Pharmacological Sciences, Vol 135, Iss 3, Pp 126-130 (2017)
Saxagliptin, a potent and selective DPP-4 inhibitor, exhibits a slow dissociation from DPP-4. We investigated the sustained effects of saxagliptin on renal DPP-4 activity in a washout study using renal tubular (HK-2) cells, and in a pharmacodynamic s
Externí odkaz:
https://doaj.org/article/4850ac17a9bd45a3be39b4af856c75ed
Autor:
Keiji Uehara, Toshimasa Harumoto, Asana Makino, Yasuo Koda, Junko Iwano, Yasuhiro Suzuki, Mari Tanigawa, Hiroto Iwai, Kana Asano, Kana Kurihara, Akinori Hamaguchi, Hiroshi Kodaira, Toshiyuki Atsumi, Yoji Yamada, Kazuma Tomizuka
Publikováno v:
Nucleic Acids Research. 50:4840-4859
Extrahepatic delivery of small interfering RNAs (siRNAs) may have applications in the development of novel therapeutic approaches. However, reports on such approaches are limited, and the scarcity of reports concerning the systemically targeted deliv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d581236601cae7f4b76162afe1df9667
https://doi.org/10.1093/nar/gkac308
https://doi.org/10.1093/nar/gkac308
Autor:
Yuhei Hotta, Shunji Kunori, Satoshi Saeki, Tetsuya Kitayama, Mariko Sakai, Masako Uchii, Naoya Kimoto, Akinori Hamaguchi
Publikováno v:
Journal of Pharmacological Sciences, Vol 135, Iss 3, Pp 126-130 (2017)
Saxagliptin, a potent and selective DPP-4 inhibitor, exhibits a slow dissociation from DPP-4. We investigated the sustained effects of saxagliptin on renal DPP-4 activity in a washout study using renal tubular (HK-2) cells, and in a pharmacodynamic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d0ab5a15e9e53d7cf51eb6bc005312
https://doi.org/10.1016/j.jphs.2017.10.003
https://doi.org/10.1016/j.jphs.2017.10.003
Publikováno v:
Hypertension. 34:126-131
Abstract —We have previously demonstrated that angiotensin II (Ang II) contributes to the increase in aortic transforming growth factor-β 1 (TGF-β 1 ) mRNA levels in hypertensive rats. However, the molecular mechanism whereby Ang II promotes TGF-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae88edaa2b6f1b3cb7974ae7e4e74969
https://doi.org/10.1161/01.hyp.34.1.126
https://doi.org/10.1161/01.hyp.34.1.126
Autor:
Hiroshi Iwao, Hiroshi Kido, Masanori Yoshizumi, Shokei Kim, Hitoshi Houchi, Koichiro Tsuchiya, Akinori Hamaguchi, Shoji Kagami, Toshiaki Tamaki
Publikováno v:
British Journal of Pharmacology. 125:1019-1027
1 We have previously found that human chymase cleaves big endothelins (ETs) at the Tyr31-Gly32 bond and produces 31-amino acid ETs (1-31), without any further degradation products. In this study, we investigated the effect of synthetic ET-1 (1-31) on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c88f1ad555fc5a77a77b91c1eafdb70
https://doi.org/10.1038/sj.bjp.0702141
https://doi.org/10.1038/sj.bjp.0702141
Autor:
Akinori Hamaguchi, Shinya Yamanaka, Hiroshi Iwao, Shokei Kim, Yutaka Nakamura, Tatsunori Masuda, Masumi Seto, Hiroto Yoshifusa
Publikováno v:
Journal of the American Society of Nephrology. 9:1367-1376
In vitro data support that activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) regulate the gene expression of numerous growth factors and cytokines involved in the development of glomerulonephritis (GN). However, the in vivo activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a68095e26432243ad91856e539a876b
https://doi.org/10.1681/asn.v981367
https://doi.org/10.1681/asn.v981367
Autor:
Hitoshi Miyazaki, Akinori Hamaguchi, Shinya Yamanaka, Yasukatsu Izumi, Katsuyuki Miura, Hiroshi Iwao, Shokei Kim, Masahiko Yano
Publikováno v:
Circulation. 97:1731-1737
Background —The effect of balloon injury on the arterial signal transduction pathway has not been examined. In vitro studies show that extracellular signal-regulated kinases (ERKs) and c-Jun NH 2 -terminal kinases (JNKs), belonging to the mitogen-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a474c1c50e599a479a91fced3d348990
https://doi.org/10.1161/01.cir.97.17.1731
https://doi.org/10.1161/01.cir.97.17.1731
Autor:
Akinori Hamaguchi, Shinya Yamanaka, Hideki Wanibuchi, Katsuyuki Miura, Hiroshi Iwao, Shokei Kim
Publikováno v:
Hypertension. 30:1054-1061
Abstract Using Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a new model of human non–insulin-dependent diabetes mellitus (NIDDM), we examined the role of local angiotensin II in cardiovascular and renal complications of NIDDM. OLETF rats were or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13cfd1e97b30c014f72b812db373ae4d
https://doi.org/10.1161/01.hyp.30.5.1054
https://doi.org/10.1161/01.hyp.30.5.1054
Publikováno v:
European Journal of Pharmacology. 322:59-62
Cardiac gene expressions of collagen and contractile proteins were examined in rats treated with a nitric oxide (NO) synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME), for 3 weeks. The rats became hypertensive, which caused left ventricul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888f91df83fe015b004380cdfabdfb9e
https://doi.org/10.1016/s0014-2999(97)00058-7
https://doi.org/10.1016/s0014-2999(97)00058-7
Publikováno v:
Journal of the American Society of Nephrology. 7:687-693
Recent studies on various models of glomerular diseases indicate that glomerular injury is associated with the phenotypic modulation of glomerular cells. However, the effect of renoprotective agents on glomerular phenotype remains to be determined. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f85531f4a4e8fa44c77a44ef25ff4ec
https://doi.org/10.1681/asn.v75687
https://doi.org/10.1681/asn.v75687