Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Akinori, Suginaka"'
Autor:
Yoshinao Kobayashi, Xiaoen Wang, Robert M. Hoffman, Xinghua Sun, Yuying Tan, Shigeo Yagi, Zhijian Yang, Shukuan Li, Takayuki Yoshioka, Tomoaki Takakura, Nan Zhang, Akinori Suginaka, Akio Takimoto, Eugene P. Frenkel
Publikováno v:
Cancer Research. 64:5775-5778
Recombinant methioninase (rMETase) has been shown to target the elevated methionine (MET) dependence of tumor cells and arrest their growth as well as make tumors more sensitive to standard chemotherapy agents. Polyethylene glycol (PEG)-modified rMET
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e1956620cd72e904e1577c5e14b20ed
https://doi.org/10.1158/0008-5472.can-04-1406
https://doi.org/10.1158/0008-5472.can-04-1406
Autor:
Akinori Suginaka, Jun-Ichi Hosoda, Motoharu Iwatsuru, Sakae Unezaki, Osamu Ishida, Kazuo Maruyama
Publikováno v:
International Journal of Pharmaceutics. 126:41-48
Enhanced delivery of doxorubicin (DXR) to colon 26 in mice was studied by the long-circulating liposomes (LCL) composed of distearoylphosphatidylcholine cholesterol (DSPC CH) (1 1. m m) and 6 mol° distearoyl phosphatidyl ethanolamine (DSPE) derivati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffdb3a6a31176dbd4c1a6407315197d1
https://doi.org/10.1016/0378-5173(95)04074-9
https://doi.org/10.1016/0378-5173(95)04074-9
Autor:
Kazuo Maruyama, Akinori Suginaka, Sakae Unezaki, Tsutomu Yuda, Noriyuki Takahashi, Motoharu Iwatsuru, Masataka Koyama
Publikováno v:
Pharmaceutical Research. 11:1180-1185
Enhanced delivery of doxorubicin (DXR) to a solid tumor subjected to local hyperthermia was achieved by using long-circulating, thermosensitive liposomes (TSL) composed of dipalmitoyl phosphatidylcholine (DPPC)/distearoyl phosphatidylcholine (DSPC) (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0df3f612b9576605ac5d96fac923450c
https://doi.org/10.1023/a:1018949218380
https://doi.org/10.1023/a:1018949218380
Autor:
Noriyuki Takahashi, Leaf Huang, Motoharu Iwatsuru, Akinori Suginaka, Tsutomu Yuda, Sakae Unezaki, Osamu Ishida, Kazuo Maruyama
Publikováno v:
Journal of Liposome Research. 4:143-165
Long-circulating liposomes containing amphipathic polyethyleneglycol (PEG) or ganglioside GM1 (GM1) have been tested for their utility as enhanced delivery system of doxorubicin (DXR) in vivo. DXR was entrapped into liposomes by pH gradient method.Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85df4fddf03a29938bdb4792e999d6cc
https://doi.org/10.3109/08982109409037034
https://doi.org/10.3109/08982109409037034
Autor:
Motohary Iwatsuru, Osamu Ishida, Akinori Suginaka, Aki Okamoto, Shuji Kojima, Leaf Huang, Kazuo Maruyama
Publikováno v:
Journal of Liposome Research. 4:701-723
Biodistribution and antitumor effect of adriamycin (ADM) encapsulated in liposomes with reduced uptake by reticuloendothelial system (RES) and prolonged circulation time were investigated in mice. Two different types of long-circulating liposomes, ga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9fe1d606bfb407ebd9caf479207b254
https://doi.org/10.3109/08982109409037067
https://doi.org/10.3109/08982109409037067
Autor:
Akinori Suginaka, Sakae Unezaki, Osamu Ishida, Motoharu Iwatsuru, Noriyuki Takahashi, Kazuo Maruyama
Publikováno v:
Drug Delivery System. 9:185-192
Long-circulating liposomes containing amphipathic polyethyleneglycol (PEG) have been tested for their utility as enhanced delivery system of doxorubicin(DXR) to the solid tumor. Inclusion of PEG to the small unilamellar liposomes(SUV, DSPC/CH (1 : 1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4a57869153d30a2ba70968b68aef22b
https://doi.org/10.2745/dds.9.185
https://doi.org/10.2745/dds.9.185
Publikováno v:
Polymer Journal. 25:355-361
A water-soluble polymer having galactose pendant groups was prepared by the synthesis and radical polymerization of p-vinylbenzyl galactoside. Copolymerization of the galactoside with p-vinylphenyl acetate and subsequent [125I]labeling by a chloramin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57b59cf26fb098f4311b2d1205fd37e6
https://doi.org/10.1295/polymj.25.355
https://doi.org/10.1295/polymj.25.355
Publikováno v:
Drug Delivery System. 7:345-350
Large unilamellar liposomes (LUV), which have a large entrapped volume and efficient drug capture characteristics, are rapidly and efficiently taken up by the RES cells in liver and spleen. A prolonged residence of the drug-entrapped liposomes in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e14b7fa17bf2be8c55c0867b78a421f
https://doi.org/10.2745/dds.7.345
https://doi.org/10.2745/dds.7.345
Autor:
Xinghua, Sun, Zhijian, Yang, Shukuan, Li, Yuying, Tan, Nan, Zhang, Xiaoen, Wang, Shigeo, Yagi, Takayuki, Yoshioka, Akio, Takimoto, Kenji, Mitsushima, Akinori, Suginaka, Eugene P, Frenkel, Robert M, Hoffman
Publikováno v:
Cancer research. 63(23)
Recombinant methioninase (rMETase) is an enzyme active in preclinical mouse models of human cancer. The efficacy of rMETase is due to depletion of plasma methionine, an amino acid for which tumors generally have an abnormally high methionine requirem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::777437ffcf60736892610f7af5d747a3
https://pubmed.ncbi.nlm.nih.gov/14678999
https://pubmed.ncbi.nlm.nih.gov/14678999
Publikováno v:
Biochimica et biophysica acta. 1128(1)
The effect of poly(ethylene glycol) (PEG) on the circulation time of liposomes in mice was examined by employing amphipathic PEGs (phosphatidylethanolamine (PE) derivatives of PEG) with average molecular weights of 1000, 2000, 5000 and 12,000. The ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea4e2c8468bdfed392b437c35e4ea208
https://pubmed.ncbi.nlm.nih.gov/1390877
https://pubmed.ncbi.nlm.nih.gov/1390877