Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Akinobu Matsuzawa"'
Autor:
Kazuyuki Sugita, Eiji Nagata, Hisaaki Sakate, Takaharu Okada, Shinya Adachi, Shogo Kamo, Akinobu Matsuzawa
Publikováno v:
Synthesis. 55:663-669
In this article, we report the synthesis of (±)-5-epi-vetiverianine A. The key reactions, including a rhodium-catalyzed coupling reaction and an oxidative phenolic cyclization, allow for efficient and stereoselective access to (±)-5-epi-vetiveriani
Publikováno v:
European Journal of Organic Chemistry. 2022
Autor:
Shinya Adachi, Kazuyuki Sugita, Tomoya Mashiko, Akinobu Matsuzawa, Shogo Kamo, Jun Sakai, Yuta Shingai
Publikováno v:
Angewandte Chemie. 133:24689-24692
Herein, we describe the first total synthesis of cochlearol B, a meroterpenoid natural product featuring a 4/5/6/6/6-fused pentacyclic structure. Key steps, oxidative cyclization and subsequent intramolecular [2+2] photocycloaddition, which construct
Publikováno v:
Topics in Catalysis. 65:96-104
In this short review, we provide an account of a number of computational studies of catalytic reaction mechanisms carried out in our groups. We focus in particular on studies in which we came to realize during the course of the investigation that the
Publikováno v:
Synthesis. 53:2092-2102
In this paper, the synthesis of the carbon skeleton of cotylenin A aglycone is described. The key reactions, including an intramolecular aldol reaction, an aldol coupling reaction, and a ring-closing metathesis, allow for the effective and stereose
Autor:
Yoshiyuki Iwase, Takamichi Arima, Kanako Miyano, Michiko Narita, Minoru Narita, Yukari Suda, Naoko Kuzumaki, Shigeru Sasaki, Tomohisa Mori, Yusuke Hamada, Kazuyuki Sugita, Kimio Higashiyama, Shoki Matsumura, Yasuhito Uezono, Mitsuaki Yamazaki, Akinobu Matsuzawa, Takayasu Yamauchi, Yoshinori Takemura
Publikováno v:
Biochemical and Biophysical Research Communications. 534:988-994
TRV130 (oliceridine), a G protein-biased ligand for μ-opioid receptor, has recently been synthesized. It is considered to have strong antinociceptive effects and only minor adverse effects. However, whether or not oliceridine actually exhibits an id
Publikováno v:
Organic Chemistry Frontiers. 8:6063-6066
In this study, concise total syntheses of Peniclillium sesquiterpenes (±)-Penicibilaenes A and B are described. This approach involves an effective intramolecular aldol condensation to construct a bicyclic skeleton, a stereoselective rhodium-catalyz
Autor:
Shinya Adachi, Ayumu Miyashita, Motoi Kuwabara, Akinobu Matsuzawa, Rintaro Matsuo, Kazuyuki Sugita
Publikováno v:
Synlett. 31:1800-1804
We have developed a concise diastereoselective total synthesis of (±)-parvistemonine A. By using a Mukaiyama–Michael addition, an aza-Wittig reaction, a Paal–Knorr pyrrole synthesis, an acid-mediated annulation, and a Mitsunobu reaction as key s
Publikováno v:
Organic letters. 24(3)
In this study, we achieved an eight-step enantioselective synthesis of (-)-lamellodysidine A, a structurally intriguing sesquiterpene natural product featuring a 5/5/6/6-fused tetracyclic skeleton that was obtained from the marine sponge
Autor:
Akihiko Kasamatsu, Yuta Katsumura, Shogo Kamo, Tomoya Mashiko, Yuta Nakazato, Shinya Adachi, Kazuyuki Sugita, Akinobu Matsuzawa
Publikováno v:
Organicbiomolecular chemistry. 19(23)
The first total synthesis of corallocin A is described herein. The Suzuki coupling reaction as a key step proceeded with high stereoselectivity and in good yield. Robust transformations, including Vilsmeier–Haack formylation and Wittig reaction, al