Výsledky vyhledávání - "Akinari Hamajima"

Efficient Diastereoselective Synthesis of (2R,3R,4R)-2-Amino-3-hydroxy-4,5-dimethylhexanoic Acid, the Lactone Linkage Unit of Homophymine A

Autor: Yasumasa Hamada, Tetsuhiro Nemoto, Akinari Hamajima, Junpei Ohtaka

Publikováno v: Chemical and Pharmaceutical Bulletin. 61:245-250

For the total synthesis of novel cyclodepsipeptide homophymine A, (2R,3R,4R)-2-amino-3-hydroxy-4,5-dimethylhexanoic acid was successfully synthesized by Evans' asymmetric alkylation and the anti-selective asymmetric hydrogenation of a chiral α-amino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc3a23373b015b1dc3d179ad904aa328
https://doi.org/10.1248/cpb.c12-00944

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Asymmetric Synthesis of 2-Substituted Dihydrobenzofurans and 3-Hydroxydihydrobenzopyrans through the Enantioselective Epoxidation of O-Silyl-Protected ortho-Allylphenols

Autor: Yasumasa Hamada, Akinari Hamajima, Hang Jiang, Takaya Sugiyama

Publikováno v: Advanced Synthesis & Catalysis. 353:155-162

The Shi-type epoxidation of O-tert-butyldiphenylsilyl (TBDPS) protected o-allylphenols serves as an efficient strategy to construct the dihydrobenzofurans and dihydrobenzopyrans in up to 97% ee. This methodology led to the enantioselective synthesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40f04a2e9309849070867af4d19eeacd
https://doi.org/10.1002/adsc.201000505

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Reagent-controlled diastereoselective synthesis of (2S,3R)- and (2R,3R)-2,3-diaminobutanoic acid derivatives using proline-catalyzed α-hydrazination reaction

Autor: Kazuishi Makino, Sayaka Kubota, Sousuke Hara, Masaru Sakaguchi, Yasumasa Hamada, Akinari Hamajima

Publikováno v: Tetrahedron. 65:9468-9473

(2S,3R)- and (2R,3R)-2,3-Diaminobutanoic acid (Dab) derivatives were efficiently synthesized from Cbz-(R)-alanine using the proline-catalyzed diastereoselective α-hydrazination reaction and the SmI2-promoted reductive cleavage of the N–N bond as t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::10037afe2ceeafb14b27383049077653
https://doi.org/10.1016/j.tet.2009.08.064

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Total Synthesis of Ciguatoxin

Autor: Minoru Isobe, Akinari Hamajima

Publikováno v: Angewandte Chemie. 121:2985-2989

Something fishy: Ciguatoxin (see structure) is one of the principal toxins involved in ciguatera poisoning and the target of a total synthesis involving the coupling of three segments. The key transformations in this synthesis feature acetylene-dicob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b0d3d1411dc5f92ef07e1731504583
https://doi.org/10.1002/ange.200805996

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Synthesis of symmetric HIJ-ring model of ciguatoxin

Autor: Minoru Isobe, Akinari Hamajima, Akihito Nonoyama

Publikováno v: Tetrahedron. 63:5886-5894

A tricyclic model ether compound comprising 6/8/6 ether rings was synthesized via a new route including conjugate addition to form a symmetric eight-membered ether-ketone with syn/trans stereochemistry in selective manner. The corresponding vinyl tri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72bcbd094138c6bcb73966006e2a48b3
https://doi.org/10.1016/j.tet.2007.03.012

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ChemInform Abstract: Enantioselective Synthesis of (R)-Sumanirole Using Organocatalytic Asymmetric Aziridination of an α,β-Unsaturated Aldehyde

Autor: Tetsuhiro Nemoto, Akinari Hamajima, Dashuang Xu, Yasumasa Hamada, Minami Hayashi

Publikováno v: ChemInform. 46

Herein we report an enantioselective synthesis of ( R )-Sumanirole wherein an organocatalytic asymmetric aziridination of 2-nitrocinnamaldehyde was the key step.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb16a288779cf34baacaaef45b2c23d3
https://doi.org/10.1002/chin.201507280

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Biological activity of the functional epitope of ciguatoxin fragment AB on the neuroblastoma sodium channel in tissue culture

Autor: Akinari Hamajima, Minoru Isobe, Nicole Higa, Yoshitsugi Hokama, C. Suma, Cara Empey Campora, K.E. Chun

Publikováno v: Journal of Clinical Laboratory Analysis. 20:126-132

It is well established that the targeted receptor for ciguatoxin (CTX) in mammalian tissues is the sodium channel, affecting the influx of sodium into cells and altering the action potential and function of the cell. Since the syntheses of fragments

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ae8ccb103a455a292fbf75df07feff
https://doi.org/10.1002/jcla.20114

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Mechanistic studies on the hydrosilylation of an acetylene cobalt complex; trapping an active catalyst Co2(CO)6 causing olefin-isomerization and O-silylation

Autor: Hiromichi Tanda, Takayuki Baba, Shigeyuki Takai, Minoru Isobe, Akinari Hamajima, Kazunobu Kira

Publikováno v: Tetrahedron. 58:6485-6492

We have recently reported a hydrosilylation reaction of acetylene cobalt complexes to produce the corresponding vinylsilanes. It has become clear that olefin-isomerization and O-silylation occurred under some hydrosilylation conditions. To avoid thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd29f7ed25d7151f426a0ab001f2b7c6
https://doi.org/10.1016/s0040-4020(02)00659-2

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Synthesis of the BCD-ring of ciguatoxin 1B using an acetylene cobalt complex and vinylsilane strategy

Autor: Kazunobu Kira, Akinari Hamajima, Minoru Isobe

Publikováno v: Tetrahedron. 58:1875-1888

Synthesis of the tricyclic BCD-ring segment with high stereoselectivity has been achieved starting from a sugar derivative directed toward the synthesis of the left part of ciguatoxin 1B. The central reactions in the synthesis are (i) ether ring form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ccf844cc40eeb446b1258f39dc4a2ec8
https://doi.org/10.1016/s0040-4020(02)00044-3

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