Zobrazeno 1 - 10
of 377
pro vyhledávání: '"Akimitsu Okamoto"'
Autor:
Shinya Yamahira, Hidefumi Mitsuno, Misato Yamaoka, Teruyuki Nagamune, Akimitsu Okamoto, Ryohei Kanzaki, Satoshi Yamaguchi
Publikováno v:
Biosensors and Bioelectronics: X, Vol 18, Iss , Pp 100473- (2024)
A technology that can effectively distinguish between various odorants with high sensitivity and selectivity has numerous applications ranging from water quality testing to disease diagnosis. Here, we report a cell-based odorant-sensing display that
Externí odkaz:
https://doaj.org/article/f11fab73991845b8bad8ec15b4e8c3c5
Autor:
Melvin Pan, Christiane Zorbas, Maki Sugaya, Kensuke Ishiguro, Miki Kato, Miyuki Nishida, Hai-Feng Zhang, Marco M. Candeias, Akimitsu Okamoto, Takamasa Ishikawa, Tomoyoshi Soga, Hiroyuki Aburatani, Juro Sakai, Yoshihiro Matsumura, Tsutomu Suzuki, Christopher G. Proud, Denis L. J. Lafontaine, Tsuyoshi Osawa
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Small molecules that target RNA Polymerase I inhibit ribosome biogenesis to activate p53 through the nucleolar surveillance response pathway. Here, the authors show that p53 induction by ribosome stress is dependent on extracellular glutamine availab
Externí odkaz:
https://doaj.org/article/5a2c48021da748188909409721466a55
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
DNA methylation plays an important physiological function in cells, and environmental changes result in fluctuations in DNA methylation levels. Metal ions have become both environmental and health concerns, as they have the potential to disrupt the g
Externí odkaz:
https://doaj.org/article/e4cf6f1347fc4a999c5a5a86f71e0023
Autor:
Ryota Itaya, Wakana Idei, Takashi Nakamura, Tatsuya Nishihara, Ryohsuke Kurihara, Akimitsu Okamoto, Kazuhito Tanabe
Publikováno v:
ACS Omega, Vol 6, Iss 47, Pp 31595-31604 (2021)
Externí odkaz:
https://doaj.org/article/06eb02dcc7164ac9baf19b267a6fd4a8
Autor:
Sae Suzuki, Yuya Nakajima, Naoki Kamo, Akihisa Osakabe, Akimitsu Okamoto, Gosuke Hayashi, Hiroshi Murakami
Publikováno v:
Molecules, Vol 28, Iss 9, p 3655 (2023)
Thiol catalysts are essential in native chemical ligation (NCL) to increase the reaction efficiency. In this paper, we report the use of thiocholine in chemical protein synthesis, including NCL-based peptide ligation and metal-free desulfurization. E
Externí odkaz:
https://doaj.org/article/a824ab86b6404c34818ed9b9438ba516
Autor:
Akimitsu Okamoto
Publikováno v:
Applied Microscopy, Vol 49, Iss 1, Pp 1-7 (2019)
Abstract Fluorescence imaging of nucleic acids is a very important technique necessary to understand gene expression and the resulting changes in cell function. This mini-review focuses on sequence-specific fluorescence imaging of intracellular RNA a
Externí odkaz:
https://doaj.org/article/33274f9424c64ee29e8bb5eafe692b09
One-Pot, Photocontrolled Enzymatic Assembly of the Structure-Defined Heterotypic Polyubiquitin Chain
Autor:
Takafumi Furuhata, Phebee Angeline Devadasan Racheal, Iori Murayama, Usano Toyoda, Akimitsu Okamoto
Publikováno v:
Journal of the American Chemical Society. 145:11690-11700
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7169057e7811e08afd8cb2694172c7b1
https://doi.org/10.1021/jacs.3c01912
https://doi.org/10.1021/jacs.3c01912
Oncolytic Hairpin DNA Pair: Selective Cytotoxic Inducer through MicroRNA-Triggered DNA Self-Assembly
Autor:
Kunihiko Morihiro, Hiraki Osumi, Shunto Morita, Takara Hattori, Manami Baba, Naoki Harada, Riuko Ohashi, Akimitsu Okamoto
Publikováno v:
Journal of the American Chemical Society. 145:135-142
Artificial nucleic acids have attracted much attention as potential cancer immunotherapeutic materials because they are recognized by a variety of extracellular and intracellular nucleic acid sensors and can stimulate innate immune responses. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bff7fcb87c614c99d06f73eeb1cf14f
https://doi.org/10.1021/jacs.2c08974
https://doi.org/10.1021/jacs.2c08974
Autor:
Yoshino Akizuki, Mai Morita, Yuki Mori, Ai Kaiho-Soma, Shivani Dixit, Akinori Endo, Marie Shimogawa, Gosuke Hayashi, Mikihiko Naito, Akimitsu Okamoto, Keiji Tanaka, Yasushi Saeki, Fumiaki Ohtake
Publikováno v:
Nature Chemical Biology. 19:311-322
Targeted protein degradation through chemical hijacking of E3 ubiquitin ligases is an emerging concept in precision medicine. The ubiquitin code is a critical determinant of the fate of substrates. Although two E3s, CRL2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf421bd83d488f3135158c321fa1f64
https://doi.org/10.1038/s41589-022-01178-1
https://doi.org/10.1038/s41589-022-01178-1
Autor:
Shinya Yamahira, Ryuji Misawa, Takahiro Kosaka, Mondong Tan, Shin Izuta, Hayato Yamashita, Yuji Heike, Akimitsu Okamoto, Teruyuki Nagamune, Satoshi Yamaguchi
Publikováno v:
Journal of the American Chemical Society. 144:13154-13162
Versatile methods for patterning multiple types of cells with single-cell resolution have become an increasingly important technology for cell analysis, cell-based device construction, and tissue engineering. Here, we present a photoactivatable mater
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8e940ee5b9e945480b012416aa7375
https://doi.org/10.1021/jacs.2c02949
https://doi.org/10.1021/jacs.2c02949