The MTR4/hnRNPK complex surveils aberrant polyadenylated RNAs with multiple exons.

Autor: Taniue K; Isotope Science Center, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan. kenzui@ric.u-tokyo.ac.jp.; Department of Medicine, Asahikawa Medical University, 2-1 Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan. kenzui@ric.u-tokyo.ac.jp., Sugawara A; Isotope Science Center, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan., Zeng C; Faculty of Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo, 169-8555, Japan., Han H; Isotope Science Center, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan., Gao X; Isotope Science Center, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan., Shimoura Y; Isotope Science Center, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan., Ozeki AN; Isotope Science Center, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan., Onoguchi-Mizutani R; Isotope Science Center, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan., Seki M; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba, 277-8561, Japan., Suzuki Y; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba, 277-8561, Japan., Hamada M; Faculty of Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo, 169-8555, Japan.; AIST-Waseda University Computational Bio Big-Data Open Innovation Laboratory (CBBD-OIL), National Institute of Advanced Industrial Science and Technology (AIST), 3-4-1 Okubo, Shinjuku-ku, Tokyo, 169-8555, Japan., Akimitsu N; Isotope Science Center, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan. akimitsu@ric.u-tokyo.ac.jp.

Publikováno v: Nature communications [Nat Commun] 2024 Oct 17; Vol. 15 (1), pp. 8684. Date of Electronic Publication: 2024 Oct 17.

Multi-omics analysis using antibody-based in situ biotinylation technique suggests the mechanism of Cajal body formation.

Autor: Noguchi K; Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan., Suzuki H; Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan., Abe R; Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan., Horiuchi K; Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan., Onoguchi-Mizutani R; R&D Department, Isotope Science Center, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan., Akimitsu N; R&D Department, Isotope Science Center, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan., Ogawa S; Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan., Akiyama T; Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan., Ike Y; Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan., Ino Y; Advance Medical Research Center, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 216-0004, Japan., Kimura Y; Advance Medical Research Center, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 216-0004, Japan., Ryo A; Department of Microbiology, Yokohama City University Graduate School of Medical Science, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 216-0004, Japan; Department of Virology III, National Institute of Infectious Diseases, 4-7-1, Gakuen Musashimurayama-shi, Tokyo 208-0011, Japan., Doi H; Department of Neurology and Stroke Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan., Tanaka F; Department of Neurology and Stroke Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan., Suzuki Y; Laboratory of Systems Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8562, Japan., Toyoda A; Comparative Genomics Laboratory, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411-8540, Japan., Yamaguchi Y; School of Life Science and Technology, Tokyo Institute of Technology, 4259 Nagatsuta, Yokohama, Kanagawa 226-8501, Japan. Electronic address: yyamaguc@bio.titech.ac.jp., Takahashi H; Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan. Electronic address: hide0213@yokohama-cu.ac.jp.

Publikováno v: Cell reports [Cell Rep] 2024 Sep 24; Vol. 43 (9), pp. 114734. Date of Electronic Publication: 2024 Sep 15.

Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms.

Autor: Shima Y; Biomedical Neural Dynamics Collaboration Laboratory, RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan.; Neurodegenerative Disorders Collaboration Laboratory, RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan., Sasagawa S; Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan., Ota N; Biomedical Neural Dynamics Collaboration Laboratory, RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan.; Department of Neurosurgery, Sapporo Teishinkai Hospital, Sapporo, Hokkaido 065-0033, Japan., Oyama R; Biomedical Neural Dynamics Collaboration Laboratory, RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan., Tanaka M; Biomedical Neural Dynamics Collaboration Laboratory, RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan.; Division of Innovative Cancer Therapy and Department of Surgical Neuro-Oncology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan., Kubota-Sakashita M; Department of Psychiatry and Behavioral Science, Juntendo University Graduate School of Medicine, Tokyo 113-0033, Japan., Kawakami H; Department of Psychiatry and Behavioral Science, Juntendo University Graduate School of Medicine, Tokyo 113-0033, Japan., Kobayashi M; Isotope Science Center, University of Tokyo, Tokyo 113-0032, Japan., Takubo N; Isotope Science Center, University of Tokyo, Tokyo 113-0032, Japan., Ozeki AN; Isotope Science Center, University of Tokyo, Tokyo 113-0032, Japan., Sun X; Isotope Science Center, University of Tokyo, Tokyo 113-0032, Japan., Kim YJ; Department of Biochemistry, Faculty of Medicine and Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan., Kamatani Y; Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo 108-8639, Japan., Matsuda K; Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo 108-8639, Japan., Maejima K; Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan., Fujita M; Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan., Noda K; Department of Neurosurgery, Sapporo Teishinkai Hospital, Sapporo, Hokkaido 065-0033, Japan., Kamiyama H; Department of Neurosurgery, Sapporo Teishinkai Hospital, Sapporo, Hokkaido 065-0033, Japan., Tanikawa R; Department of Neurosurgery, Sapporo Teishinkai Hospital, Sapporo, Hokkaido 065-0033, Japan., Nagane M; Department of Neurosurgery, Faculty of Medicine, Kyorin University, Mitaka, Tokyo 181-8611, Japan., Shibahara J; Department of Pathology, Faculty of Medicine, Kyorin University, Mitaka, Tokyo 181-8611, Japan., Tanaka T; Laboratory of Medical Pharmaceutics, Kobe Pharmaceutical University, Kobe, Hyogo 658-8558, Japan., Rikitake Y; Laboratory of Medical Pharmaceutics, Kobe Pharmaceutical University, Kobe, Hyogo 658-8558, Japan., Mataga N; Support Unit for Bio-Material Analysis, Research Resources Division, RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan., Takahashi S; Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-0005, Japan., Kosaki K; Center for Medical Genetics, Keio University Faculty of Medicine, Tokyo 160-0016, Japan., Okano H; Department of Physiology, Keio University School of Medicine, Tokyo 160-0016, Japan.; Laboratory for Marmoset Neural Architecture, Center for Brain Science, RIKEN, Wako, Saitama 351-0198, Japan.; International Center for Brain Science, Fujita Health University, Toyoake, Aichi 470-1192, Japan., Furihata T; Laboratory of Clinical Pharmacy and Experimental Therapeutics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan., Nakaki R; Rhelixa Inc., Tokyo 104-0042, Japan., Akimitsu N; Isotope Science Center, University of Tokyo, Tokyo 113-0032, Japan., Wada Y; Isotope Science Center, University of Tokyo, Tokyo 113-0032, Japan., Ohtsuka T; Department of Biochemistry, Faculty of Medicine and Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan., Kurihara H; Department of Molecular Cell Biology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo 113-8654, Japan., Kamiguchi H; Laboratory for Neural Cell Dynamics, RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan., Okabe S; Department of Cellular Neurobiology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo 113-8654, Japan.; Brain Medical Science Collaboration Division, RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan., Nakafuku M; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Kato T; Department of Psychiatry and Behavioral Science, Juntendo University Graduate School of Medicine, Tokyo 113-0033, Japan., Nakagawa H; Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan., Saito N; Department of Neurosurgery, Graduate School of Medicine, University of Tokyo, Tokyo 113-8654, Japan., Nakatomi H; Biomedical Neural Dynamics Collaboration Laboratory, RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan.; Department of Neurosurgery, Faculty of Medicine, Kyorin University, Mitaka, Tokyo 181-8611, Japan.; Department of Neurosurgery, Graduate School of Medicine, University of Tokyo, Tokyo 113-8654, Japan.

Publikováno v: Science translational medicine [Sci Transl Med] 2023 Jun 14; Vol. 15 (700), pp. eabq7721. Date of Electronic Publication: 2023 Jun 14.

Aberrant phase separation and cancer.

Autor: Taniue K; Isotope Science Center, The University of Tokyo, Japan.; Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Japan., Akimitsu N; Isotope Science Center, The University of Tokyo, Japan.

Publikováno v: The FEBS journal [FEBS J] 2022 Jan; Vol. 289 (1), pp. 17-39. Date of Electronic Publication: 2021 Mar 03.

A preliminary biodistribution study of [ ^99m Tc]sodium pertechnetate prepared from an electron linear accelerator and activated carbon-based ^99m Tc generator.

Autor: Jang J; Department of Bioengineering, School of Engineering, University of Tokyo, Bunkyo, Tokyo 113-8656, Japan. Electronic address: jangj@korea.ac.kr., Kumakura Y; Department of Diagnostic Radiology and Nuclear Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama 350-8550, Japan; Isotope Science Center, University of Tokyo, Bunkyo, Tokyo 113-0032, Japan., Tatenuma K; Kaken Inc., Mito, Ibaraki 310-0903, Japan., Ozeki AN; Isotope Science Center, University of Tokyo, Bunkyo, Tokyo 113-0032, Japan., Wada Y; Isotope Science Center, University of Tokyo, Bunkyo, Tokyo 113-0032, Japan., Akimitsu N; Isotope Science Center, University of Tokyo, Bunkyo, Tokyo 113-0032, Japan., Tsuguchi A; Kaken Inc., Mito, Ibaraki 310-0903, Japan., Kikunaga H; Research Center for Electron Photon Science, Tohoku University, Sendai, Miyagi 982-0826, Japan., Higaki S; Isotope Science Center, University of Tokyo, Bunkyo, Tokyo 113-0032, Japan., Uesaka M; Department of Bioengineering, School of Engineering, University of Tokyo, Bunkyo, Tokyo 113-8656, Japan; Nuclear Professional School, School of Engineering, University of Tokyo, Naka, Ibaraki 319-1188, Japan.

Publikováno v: Nuclear medicine and biology [Nucl Med Biol] 2022 Jul-Aug; Vol. 110-111, pp. 1-9. Date of Electronic Publication: 2022 Mar 17.