Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Akila Jayaraman"'
Autor:
Thomas Clark, Vidya Subramanian, Akila Jayaraman, Emmett Fitzpatrick, Ranjani Gopal, Niharika Pentakota, Troy Rurak, Shweta Anand, Alexander Viglione, Rahul Raman, Kannan Tharakaraman, Ram Sasisekharan
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract The application of machine learning (ML) models to optimize antibody affinity to an antigen is gaining prominence. Unfortunately, the small and biased nature of the publicly available antibody-antigen interaction datasets makes it challengin
Externí odkaz:
https://doaj.org/article/1dbbc8d07dad4d94bd9af58c95b39d1f
Autor:
Ranjani Gopal, Emmett Fitzpatrick, Niharika Pentakota, Akila Jayaraman, Kannan Tharakaraman, Ishan Capila
Publikováno v:
Viruses, Vol 14, Iss 12, p 2694 (2022)
The computational methods used for engineering antibodies for clinical development have undergone a transformation from three-dimensional structure-guided approaches to artificial-intelligence- and machine-learning-based approaches that leverage the
Externí odkaz:
https://doaj.org/article/785e6697f17a4990ad754227df2dff8c
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e49597 (2013)
In the context of recently emerged novel influenza strains through reassortment, avian influenza subtypes such as H5N1, H7N7, H7N2, H7N3 and H9N2 pose a constant threat in terms of their adaptation to the human host. Among these subtypes, it was rece
Externí odkaz:
https://doaj.org/article/499a621c49524985979546b90469b036
Publikováno v:
PLoS ONE, Vol 8, Iss 12 (2013)
Externí odkaz:
https://doaj.org/article/39e3af6fad7f4b1da994533e3f5a21a4
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e59550 (2013)
Avian influenza subtypes such as H5, H7 and H9 are yet to adapt to the human host so as to establish airborne transmission between humans. However, lab-generated reassorted viruses possessing hemagglutinin (HA) and neuraminidase (NA) genes from an av
Externí odkaz:
https://doaj.org/article/2a6b1b3f5453418ab168bc6a1644eb81
Autor:
Akila Jayaraman, Aarthi Chandrasekaran, Karthik Viswanathan, Rahul Raman, James G Fox, Ram Sasisekharan
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e27517 (2012)
Ferrets are widely used as animal models for studying influenza A viral pathogenesis and transmissibility. Human-adapted influenza A viruses primarily target the upper respiratory tract in humans (infection of the lower respiratory tract is observed
Externí odkaz:
https://doaj.org/article/e7f143963c904ad0af05eb2aab76f0c4
Autor:
Akila Jayaraman, Claudia Pappas, Rahul Raman, Jessica A Belser, Karthik Viswanathan, Zachary Shriver, Terrence M Tumpey, Ram Sasisekharan
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17616 (2011)
The 2009 H1N1 influenza A virus continues to circulate among the human population as the predominant H1N1 subtype. Epidemiological studies and airborne transmission studies using the ferret model have shown that the transmission efficiency of 2009 H1
Externí odkaz:
https://doaj.org/article/7bfd197d7fb44d9fbb58304ffe14c61c
Autor:
Jessica A Belser, Akila Jayaraman, Rahul Raman, Claudia Pappas, Hui Zeng, Nancy J Cox, Jacqueline M Katz, Ram Sasisekharan, Terrence M Tumpey
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25091 (2011)
Influenza viruses isolated during the 2009 H1N1 pandemic generally lack known molecular determinants of virulence associated with previous pandemic and highly pathogenic avian influenza viruses. The frequency of the amino acid substitution D222G in t
Externí odkaz:
https://doaj.org/article/af6711b2b4744f89bb515f4556f89cfc
Autor:
Gerald N. Wogan, V. Sasisekharan, Kannan Tharakaraman, Akila Jayaraman, Uma Narayanasami, Niharika Pentakota
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences
Significance The COVID-19 pandemic continues to ravage our society, posing serious economic, social, health, and educational concerns in communities. Understanding the human humoral immune response to COVID-19 infection will greatly inform public hea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4360925ac48e6dc71aaa35249c2449a4
https://doi.org/10.1073/pnas.2021615118
https://doi.org/10.1073/pnas.2021615118
Autor:
Zachary Shriver, Akila Jayaraman, Rahul Raman, Kannan Tharakaraman, Viswanathan Sasisekharan, Ram Sasisekharan
Publikováno v:
PMC
Influenza A viruses are rapidly evolving pathogens with the potential for novel strains to emerge and result in pandemic outbreaks in humans. Some avian-adapted subtypes have acquired the ability to bind to human glycan receptors and cause severe inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b04240bb23bcf245dbf6bc0dfb67fd
https://doi.org/10.1016/j.tim.2014.07.002
https://doi.org/10.1016/j.tim.2014.07.002