Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Akiko Tohgo"'
Autor:
Noriaki Kuroki, Masahiro Nakano, Akiko Tohgo, Masahiko Kikuchi, Ayumi Kumamoto, Kazuhiko Arimori, Eiji Kumazawa, Naomi Tanoue
Publikováno v:
Pharmaceutical Research. 18:814-822
Purpose. To investigate the excretion of irinotecan hydrochloride (CPT-11) and its active metabolite, SN-38, into the gastrointestinal lumen via the biliary and/or intestinal membrane route after dosing with lactone and carboxylate forms of CPT-11, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29f962a7e308884a95d9890ad7009d7d
https://doi.org/10.1023/a:1011040529881
https://doi.org/10.1023/a:1011040529881
Publikováno v:
Cancer Chemotherapy and Pharmacology. 42:210-220
Purpose: We have previously reported that DX-8951f, a water-soluble and nonprodrug camptothecin (CPT) derivative, exhibits both high in vitro potency against a series of 32 malignant cell lines and significant topoisomerase I inhibition. The purpose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c3288dfa40998a5eff937e2af45b58
https://doi.org/10.1007/s002800050807
https://doi.org/10.1007/s002800050807
Autor:
Eiji Kumazawa, Akiko Tohgo
Publikováno v:
Expert Opinion on Investigational Drugs. 7:625-632
DX-8951f is a water-soluble camptothecin analogue with a unique hexacyclic structure. Compared to other current camptothecin derivatives, DX-8951f is the most effective topoisomerase I (topo I) inhibitor and has the most potent cytotoxic activity aga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efcb69abf07676091e74edefe93ec016
https://doi.org/10.1517/13543784.7.4.625
https://doi.org/10.1517/13543784.7.4.625
Publikováno v:
Cancer Investigation. 15:522-530
We previously reported that DT-5461, a synthetic low-toxic lipid A analog, inhibits growth of various murine tumors through activation of host immune systems. In the present study, DT-5461 also exhibited significant antitumor effects against 5 out of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d0830704a5b8ed9a32a765d7c16151
https://doi.org/10.3109/07357909709047593
https://doi.org/10.3109/07357909709047593
Publikováno v:
Cancer Immunology Immunotherapy. 35:307-314
The antitumor effect of a synthetic lipid A analogue, DT-5461, was investigated using syngeneic tumor models in mice. Intravenous injection of DT-5461 into mice transplanted with solid tumors of MethA fibrosarcoma, MH134 hepatoma, MM46 mammary carcin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012280fa3cff3cccd37079dcf74e9bab
https://doi.org/10.1007/bf01741143
https://doi.org/10.1007/bf01741143
Publikováno v:
Cancer science. 94(5)
DJ-927 is a novel taxane, which was selected for high solubility, non-neurotoxicity, oral bioavailability, and potent antitumor activity. In this study, we compared the in vitro and in vivo efficacy of DJ-927 with those of paclitaxel and docetaxel. D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0540061d411eb3be0a23049d9aecf941
https://pubmed.ncbi.nlm.nih.gov/12824894
https://pubmed.ncbi.nlm.nih.gov/12824894
Autor:
Kaichiro, Yamamoto, Michio, Iwahana, Eiji, Kumazawa, Koji, Kakihata, Kunio, Abe, Fuyumi, Hirano, Akiko, Tohgo, Hiroshi, Hoshiai, Kiichiro, Noda
Publikováno v:
Oncology reports. 10(3)
Antitumor activity of combination chemotherapy with irinotecan hydrochloride (CPT-11) and nedaplatin was compared to that with CPT-11 and cisplatin. In vitro cytotoxicity of SN-38 (an active metabolite of CPT-11) in combination with nedaplatin or cis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2b03b2f15975bc82efc3a309c3e591e0
https://pubmed.ncbi.nlm.nih.gov/12684629
https://pubmed.ncbi.nlm.nih.gov/12684629
Autor:
Fang-Xian, Sun, Akiko, Tohgo, Michael, Bouvet, Shigeo, Yagi, Rounak, Nassirpour, Abdoul R, Moossa, Robert M, Hoffman
Publikováno v:
Cancer research. 63(1)
We determined the antitumor and antimetastatic efficacy of the camptothecin analogue DX-8951f in an orthotopic metastatic mouse model of pancreatic cancer. DX-8951f showed efficacy against two human pancreatic tumor cell lines in this model. These ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2bd7a8eb4695277c4b3f658b14000642
https://pubmed.ncbi.nlm.nih.gov/12517781
https://pubmed.ncbi.nlm.nih.gov/12517781
Publikováno v:
Expert review of anticancer therapy. 2(1)
Cachexia – a wasting condition – seriously impairs the quality of life of patients with advanced cancer. Previous studies have shown that several inflammatory cytokines mediate the development of cancer-associated cachexia. Experimentally, cachex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27b20b81b4c561bf8e2c59f6417d8c80
https://pubmed.ncbi.nlm.nih.gov/12113061
https://pubmed.ncbi.nlm.nih.gov/12113061
Autor:
Setsuko Imagawa, Akiko Tohgo, Michio Iwahana, Ikuo Mitsui, Megumi Minami, Mineko Ishii, Akio Ejima
Publikováno v:
Anti-cancer drugs. 11(5)
DX-8951f, a new water-soluble camptothecin (CPT) derivative, has been reported to show potent antitumor effects against various tumors in vitro and in vivo. We further evaluated the cytotoxic effect of DX-8951f against eight drug-resistant sublines d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f7aa56dbe14017a80b8d6ec0636a8b
https://pubmed.ncbi.nlm.nih.gov/10912951
https://pubmed.ncbi.nlm.nih.gov/10912951