Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Akiko Tenma"'
Autor:
Tetsuya Tomita, Hiromi Rakugi, Hiroki Hayashi, Ryuichi Morishita, Jiao Sun, Yuka Yanagida, Shota Yoshida, Satoshi Baba, Akiko Tenma, Masayoshi Toyoura, Sotaro Kawabata, Takako Ehara, Ryoko Asaki, Makoto Sakaguchi, Hideki Tomioka, Munehisa Shimamura, Hironori Nakagami
Publikováno v:
RMD Open, Vol 9, Iss 1 (2023)
Objectives Spondyloarthritis (SpA) is known as series of immune-mediated inflammatory disease of the axial and peripheral joints. Human leucocyte antigen (HLA)-B27 is a genetic risk factor for SpA. Recent evidence suggests that the interleukin −17
Externí odkaz:
https://doaj.org/article/f1e439622aa643a9ab0805098beb61be
Autor:
Shota Yoshida, Hironori Nakagami, Hiroki Hayashi, Yuka Ikeda, Jiao Sun, Akiko Tenma, Hideki Tomioka, Tomohiro Kawano, Munehisa Shimamura, Ryuichi Morishita, Hiromi Rakugi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Senotherapy, the removal of aged T cells, is an effective approach to attenuate age-related diseases. Here the authors report a CD153 targeting vaccine that prevents the accumulation of senescent adipose tissue T cells in mice on high-fat diet, which
Externí odkaz:
https://doaj.org/article/3d1a44c22d254ecbacf92a2ba8dc772e
Autor:
Akiko Tenma, Hironori Nakagami, Hideki Tomioka, Makoto Sakaguchi, Ryoko Ide, Hiroshi Koriyama, Hiroki Hayashi, Munehisa Shimamura, Hiromi Rakugi, Ryuichi Morishita
Publikováno v:
FASEB BioAdvances, Vol 1, Iss 12, Pp 760-772 (2019)
Abstract Vaccine design requires well‐tailored formulations including a T‐cell epitope and adjuvants. We identified a novel cationic peptide, AJP001, which possesses a strong affinity for murine MHC class II alleles (H2‐IEd and H2‐IAd) and lo
Externí odkaz:
https://doaj.org/article/c14c1ccfc7164384a81bdf779add2f90
Autor:
Hideki Tomioka, Hironori Nakagami, Akiko Tenma, Yoshimi Saito, Toshihiro Kaga, Toshihide Kanamori, Nao Tamura, Kazunori Tomono, Yasufumi Kaneda, Ryuichi Morishita
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92597 (2014)
We developed a novel cationic antimicrobial peptide, AG30/5C, which demonstrates angiogenic properties similar to those of LL-37 or PR39. However, improvement of its stability and cost efficacy are required for clinical application. Therefore, we exa
Externí odkaz:
https://doaj.org/article/d5754996943347d7afc9ee5bc2b88ae7
Autor:
Jiao Sun, Akiko Tenma, Hiromi Rakugi, Ryuichi Morishita, Munehisa Shimamura, Koichi Yamamoto, Hiroki Hayashi, Ryo Nakamaru, Hironori Nakagami
Publikováno v:
Journal of Hypertension
Objectives We recently developed a novel peptide, AJP001, that possesses both a mouse T-cell epitope and adjuvant action. Direct conjugation to the antigen is useful for peptide vaccines without the addition of adjuvants. In this study, the efficacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6910a50c4b4a87b2c18d1bad55ed87
https://doi.org/10.1097/hjh.0000000000002597
https://doi.org/10.1097/hjh.0000000000002597
Autor:
Hiroki Hayashi, Jiao Sun, Yuka Yanagida, Shota Yoshida, Satoshi Baba, Akiko Tenma, Masayoshi Toyoura, Sotaro Kawabata, Takako Ehara, Ryoko Asaki, Makoto Sakaguchi, Hideki Tomioka, Munehisa Shimamura, Ryuichi Morishita, Hiromi Rakugi, Tetsuya Tomita, Hironori Nakagami
Publikováno v:
RMD Open. 9:e002851
ObjectivesSpondyloarthritis (SpA) is known as series of immune-mediated inflammatory disease of the axial and peripheral joints. Human leucocyte antigen (HLA)-B27 is a genetic risk factor for SpA. Recent evidence suggests that the interleukin −17 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4647de4794424084ee32f1ced25e5dec
https://doi.org/10.1136/rmdopen-2022-002851
https://doi.org/10.1136/rmdopen-2022-002851
Autor:
Hiroki Hayashi, Ryuichi Morishita, Hironori Nakagami, Ryoko Ide, Makoto Sakaguchi, Hiromi Rakugi, Hiroshi Koriyama, Akiko Tenma, Munehisa Shimamura, Hideki Tomioka
Publikováno v:
FASEB bioAdvances
FASEB BioAdvances, Vol 1, Iss 12, Pp 760-772 (2019)
FASEB BioAdvances, Vol 1, Iss 12, Pp 760-772 (2019)
Vaccine design requires well‐tailored formulations including a T‐cell epitope and adjuvants. We identified a novel cationic peptide, AJP001, which possesses a strong affinity for murine MHC class II alleles (H2‐IEd and H2‐IAd) and low affinit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fffb5966b1595f85326432ec5c0be9e
http://europepmc.org/articles/PMC6996369
http://europepmc.org/articles/PMC6996369
Autor:
Junichi Mineno, Ritsuko Kubota-Koketsu, Shota Yoshida, Munehisa Shimamura, Akiko Tenma, Jiao Sun, Yoshimi Saito, Hisashi Arase, Makoto Sakaguchi, Hideto Chono, Yasunori Amaishi, Tatsuo Shioda, Ryo Nakamaru, Yoshiharu Matsuura, Hiromi Rakugi, Hiroki Hayashi, Hironori Nakagami, Hideki Tomioka, Sotaro Kawabata, Chikako Ono, Takako Ehara, Yuka Yanagida, Ryoko Ide, Takao Komatsuno, Nan Ju, Takako Ootera, Ryuichi Morishita, Sachiko Okamoto
Publikováno v:
SSRN Electronic Journal.
As potential pandemic vaccines, DNA/RNA vaccines, viral vector vaccines and protein-based vaccines have been rapidly developed to prevent pandemic spread worldwide. In this study, we designed plasmid DNA vaccine targeting the SARS-CoV-2 Spike glycopr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee837f9ef13dbf1a068b23bd9094ea7c
https://doi.org/10.2139/ssrn.3900407
https://doi.org/10.2139/ssrn.3900407
Autor:
Takako Otera, Shota Yoshida, Yoshimi Saito, Yasunori Amaishi, Hiroki Hayashi, Ryo Nakamaru, Sotaro Kawabata, Chikako Ono, Takako Ehara, Sachiko Okamoto, Akiko Tenma, Hisashi Arase, Ritsuko Kubota-Kotetsu, Makoto Sakaguchi, Hironori Nakagami, Tatsuo Shioda, Junichi Mineno, Hideki Tomioka, Yuka Yanagida, Yoshiharu Matsuura, Munehisa Shimamura, Jiao Sun, Hideto Chono, Hiromi Rakugi, Ryuichi Morishita, Takao Komatsuno, Ryoko Ide
To fight against the worldwide COVID-19 pandemic, the development of an effective and safe vaccine against SARS-CoV-2 is required. As potential pandemic vaccines, DNA/RNA vaccines, viral vector vaccines and protein-based vaccines have been rapidly de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d920ce20492bd059943f874071917ef9
https://doi.org/10.1101/2020.10.21.347799
https://doi.org/10.1101/2020.10.21.347799
Autor:
Akiko Tenma, Hiroki Hayashi, Shota Yoshida, Hironori Nakagami, Tomohiro Kawano, Jiao Sun, Hiromi Rakugi, Yuka Ikeda, Ryuichi Morishita, Munehisa Shimamura, Hideki Tomioka
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications
Nature Communications
Senotherapy targeting for senescent cells is designed to attenuate age-related dysfunction. Senescent T cells, defined as CD4+ CD44high CD62Llow PD-1+ CD153+ cells, accumulate in visceral adipose tissues (VAT) in obese individuals. Here, we show the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69044c5a12d27272cfa8a524f140f1a2
https://doi.org/10.1038/s41467-020-16347-w
https://doi.org/10.1038/s41467-020-16347-w