Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Akiko Soyama"'
Autor:
Kazuhisa Sakamoto, Kenji Minakata, Hikari Tsuji, Tomohiro Matsuoka, Akiko Soyama, Shogo Murakami, Kaoru Otsuka, Tatsuji Kono
Publikováno v:
Circulation. 132(24)
Penetrating atherosclerotic ulcer (PAU) is defined as ulceration of an aortic atherosclerotic plaque penetrating through the internal elastic lamina into the media.1–3 PAU accounts for 2% to 7% of all acute aortic syndrome.4 PAU is at risk of intra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9bb3e51473c4fdcd355dbb57dae07e6
https://pubmed.ncbi.nlm.nih.gov/26667100
https://pubmed.ncbi.nlm.nih.gov/26667100
Autor:
Kentaro Koike, Masaaki Nagai, Toshiyuki Imasawa, Tetsuji Nishiwaki, Ryutaro Matsumura, Akiko Soyama, Hiroshi Kitamura, Nobuaki Shikama, Motonobu Nishimura, Kensuke Joh
Publikováno v:
American Journal of Kidney Diseases. 48:495-501
A 35-year-old Japanese woman for whom a previous health checkup showed normal blood pressure and urinalysis results without serological abnormalities developed nephrotic syndrome with severe hypertension at 15 gestational weeks. The renal biopsy perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf1f821427bd47c17b3e7cc07f94dff6
https://doi.org/10.1053/j.ajkd.2006.05.024
https://doi.org/10.1053/j.ajkd.2006.05.024
Autor:
Sachiko Suematsu, Tetsuo Nishikawa, Hiroko Ito, Tomoshige Kino, Jun Saito, George P. Chrousos, Akiko Soyama
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 96:309-316
Systemic aldosterone plays an important role in the development of the microvascular disease and glomerular damage of the kidney in patients with diabetes mellitus and hyperlipidemia. Here, we investigated the possibility of local production of aldos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2333903882c1007bc98bbb3de67d9a6d
https://doi.org/10.1016/j.jsbmb.2005.03.005
https://doi.org/10.1016/j.jsbmb.2005.03.005
Autor:
Akiko Soyama, Yu-ichi Goto, Hideo Kunitoh, Erika Matsushima, Masaaki Katoh, Shogo Ozawa, Yuichiro Ohe, Shigehisa Uchiyama, Toshiko Tanaka-Kagawa, Jun-ichi Sawada, Masanori Ando, Narihiro Minami, Hideo Kimura, Satoru Koyano, Hironobu Minami, Yoshiro Saito, Kenji Sugai, Teruhiko Yoshida, Nagahiro Saijo, Hiroshi Nokihara, Hiroshi Tokunaga, Hiroyuki Hichiya, Tomohide Tamura, Noboru Yamamoto, Hideto Jinno, Noriko Katori
Publikováno v:
Drug Metabolism and Disposition. 33:630-636
Cytochrome P450 2C8 is one of the primary enzymes responsible for the metabolism of a wide range of drugs such as paclitaxel, cerivastatin, and amiodarone. We have sequenced the CYP2C8 gene from 201 Japanese subjects and found five novel nonsynonymou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5d0d2eaf90deb140d137f2fff1672e
https://doi.org/10.1124/dmd.105.003830
https://doi.org/10.1124/dmd.105.003830
Autor:
Jun-ichi Sawada, Masaya Itoda, Hideto Jinno, Yoshiro Saito, Akiko Soyama, Mayumi Saeki, Shogo Ozawa, Tetsuji Nishimura, Nobumitsu Hanioka, Toshiko Tanaka-Kagawa, Seiich Ishida, Masanori Ando
Publikováno v:
Molecular Pharmacology. 65:496-502
Human constitutive androstane (or active) receptor (hCAR), a member of the nuclear receptor superfamily NR1I3, regulates the expression of several genes that are mainly involved in the metabolism of endogenous and xenobiotic compounds (e.g., CYP2B6,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::962df3117c4158de7fc0def299e05a37
https://doi.org/10.1124/mol.65.3.496
https://doi.org/10.1124/mol.65.3.496
Autor:
Hiromi Fukushima-Uesaka, Shogo Ozawa, Mayumi Saeki, Kimie Sai, Jun-ichi Sawada, Yasuo Ohno, Masaya Itoda, Yoshiro Saito, Akiko Soyama, Satoru Koyano
Publikováno v:
Drug Metabolism and Pharmacokinetics. 19:83-95
Metabolic capacities for debrisoquin, sparteine, mephenytoin, nifedipine, and midazolam, which are substrates of polymorphic CYP2D6, CYP2C19, and CYP3A, have been reported to exhibit, in many cases, remarkable interindividual and ethnic differences.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00f7828f4130c6cc16cdf10015b0b02
https://doi.org/10.2133/dmpk.19.83
https://doi.org/10.2133/dmpk.19.83
Autor:
Shogo Ozawa, Norie Murayama, Yoshiro Saito, Jun-ichi Sawada, Nobumitsu Hanioka, Akiko Soyama, Masanori Ando
Publikováno v:
Pharmacology & Toxicology. 91:174-178
Amiodarone is a potent Class III antiarrhythmic drug. The N-deethylation of amiodarone to desethylamiodarone is known to be catalyzed by cytochrome P450 (CYP) 2C8. In the present study, amiodarone N-deethylation by the CYP2C8s, CYP2C8*1 (wild-type),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac76cb9436382e7cfc7565a8eddf4c6d
https://doi.org/10.1034/j.1600-0773.2002.910404.x
https://doi.org/10.1034/j.1600-0773.2002.910404.x
Autor:
Shiro Kamakura, Akiko Soyama, Shogo Ozawa, Kazuo Komamura, Kazuyuki Ueno, Yoshiro Saito, Jun-ichi Sawada
Publikováno v:
Drug Metabolism and Pharmacokinetics. 17:475-478
Summary: Novel single nucleotide polymorphisms (SNPs) were found in introns 1, 3, 4, 5, and 7 of the gene encoding cytochrome (CYP) 2D6 in 90 Japanese subjects. Some of these SNPs were associated with C2850T and/or C100T, which are key SNPs for CYP2D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052a18fc44a4801f75fc8f8bd0c7abd7
https://doi.org/10.2133/dmpk.17.475
https://doi.org/10.2133/dmpk.17.475
Publikováno v:
Neuroreport. 12:3217-3221
RA175, a new member of the immunoglobulin superfamily, is highly expressed during neuronal differentiation of P19 embryonal carcinoma cells. In situ hybridization showed that RA175 mRNA was detected in the developing nervous system, as well as the ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a6bae331cfe2f84560062d2cc601fe
https://doi.org/10.1097/00001756-200110290-00015
https://doi.org/10.1097/00001756-200110290-00015
Autor:
Osamu Nakajima, Noriko Katori, Kimie Sai, Yoshiro Saito, Seiichi Ishida, Norie Murayama, Akiko Soyama, Jun-ichi Sawada, Shogo Ozawa, Nobumitsu Hanioka
Publikováno v:
Biological and Pharmaceutical Bulletin. 24:1427-1430
By sequencing genomic DNA from 73 established cell lines derived from Japanese individuals, we detected 9 single nucleotide polymorphisms (SNPs) in the CYP2C8 gene. Of them, 3 exonic SNPs resulted in amino acid alterations (g416a, R139K; a1196g, K399
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9066615f41450370ed24fc004ac3c90a
https://doi.org/10.1248/bpb.24.1427
https://doi.org/10.1248/bpb.24.1427