Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Akiko Shimizugawa"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 111, Iss 3, Pp 317-321 (2009)
A pyrazolone compound acting as a formyl peptide receptor (FPR) 2/ALX–selective agonist has been reported, but its pharmacological activities on human FPRs (hFPRs) and mouse FPRs (mFprs) have not been well demonstrated. In this study, we found that
Externí odkaz:
https://doaj.org/article/49539a54f92b4e53aac32c8aeda4538d
Autor:
Yutaka Kitano, Chie Fujiwara, Sayaka Suzuki, Ryuta Koishi, Tomihisa Yokoyama, Satoshi Shibuya, Daigo Asano, Yuki Domon, Kyosuke Tanaka, Hiroko Kimoto, Akiko Shimizugawa, Tsuyoshi Shinozuka, Kazufumi Kubota, Hiroyuki Kobayashi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 68:653-663
The discovery of a novel class of state-dependent voltage-gated sodium channel (NaV)1.7 inhibitors is described. By the modification of amide or urethane bond in NaV1.7 blocker III, structure-activity relationship studies that led to the identificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89845e45af2cb38ea79da89f3f6a10c8
https://doi.org/10.1248/cpb.c20-00126
https://doi.org/10.1248/cpb.c20-00126
Autor:
Tomihisa Yokoyama, Sakiko Takahashi, Kiyoshi Takasuna, Noriyuki Hayashi, Hiroyuki Kobayashi, Ryuta Koishi, Chie Fujiwara, Eri Tokumaru, Yasuyuki Abe, Kyosuke Tanaka, Sayaka Suzuki, Kazufumi Kubota, Daigo Asano, Narayan Karanjule, Tsuyoshi Shinozuka, Masahiro Inoue, Hiroko Kimoto, Tsuda Toshifumi, Yutaka Kitano, Kiyono Ueda, Toshiyuki Watanabe, Yuki Domon, Tomoko Sakakura, Akiko Shimizugawa
Publikováno v:
Journal of Medicinal Chemistry. 63:10204-10220
A highly potent, selective NaV1.7 inhibitor, DS-1971a, has been discovered. Exploration of the left-hand phenyl ring of sulfonamide derivatives (I and II) led to the discovery of novel series of cycloalkane derivatives with high NaV1.7 inhibitory pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dfbfcf9264e87757e4b9e81ee00d139
https://doi.org/10.1021/acs.jmedchem.0c00259
https://doi.org/10.1021/acs.jmedchem.0c00259
Autor:
Kyosuke, Tanaka, Hiroyuki, Kobayashi, Sayaka, Suzuki, Satoshi, Shibuya, Hiroko, Kimoto, Yuki, Domon, Kazufumi, Kubota, Yutaka, Kitano, Tomihisa, Yokoyama, Akiko, Shimizugawa, Ryuta, Koishi, Chie, Fujiwara, Daigo, Asano, Tsuyoshi, Shinozuka
Publikováno v:
Chemicalpharmaceutical bulletin. 68(7)
The discovery of a novel class of state-dependent voltage-gated sodium channel (Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::033cc77c13c4c442b3167b8a41485a0e
https://pubmed.ncbi.nlm.nih.gov/32612000
https://pubmed.ncbi.nlm.nih.gov/32612000
Autor:
Tsuyoshi, Shinozuka, Hiroyuki, Kobayashi, Sayaka, Suzuki, Kyosuke, Tanaka, Narayan, Karanjule, Noriyuki, Hayashi, Toshifumi, Tsuda, Eri, Tokumaru, Masahiro, Inoue, Kiyono, Ueda, Hiroko, Kimoto, Yuki, Domon, Sakiko, Takahashi, Kazufumi, Kubota, Tomihisa, Yokoyama, Akiko, Shimizugawa, Ryuta, Koishi, Chie, Fujiwara, Daigo, Asano, Tomoko, Sakakura, Kiyoshi, Takasuna, Yasuyuki, Abe, Toshiyuki, Watanabe, Yutaka, Kitano
Publikováno v:
Journal of medicinal chemistry. 63(18)
A highly potent, selective Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79add99460610a6681f6e61187542eaa
https://pubmed.ncbi.nlm.nih.gov/32392056
https://pubmed.ncbi.nlm.nih.gov/32392056
Publikováno v:
Journal of Pharmacological Sciences, Vol 111, Iss 3, Pp 317-321 (2009)
A pyrazolone compound acting as a formyl peptide receptor (FPR) 2/ALX–selective agonist has been reported, but its pharmacological activities on human FPRs (hFPRs) and mouse FPRs (mFprs) have not been well demonstrated. In this study, we found that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e5841bb68e9a89141c41403fdebb31
http://www.sciencedirect.com/science/article/pii/S1347861319310990
http://www.sciencedirect.com/science/article/pii/S1347861319310990
Autor:
Tomihisa Yokoyama, Hiroko Kimoto, Daigo Asano, Ryusuke Sugita, Kazufumi Kubota, Ryuta Koishi, Takeshi Kuroda, Yuki Domon, Akiko Shimizugawa, Sayaka Suzuki, Kazuhiko Tamaki, Yutaka Kitano, Tsuyoshi Shinozuka, Hiroyuki Kobayashi
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(22)
A novel class of NaV1.7 inhibitors has been identified by high-throughput screening followed by structure activity relationship studies. Among this series of compounds, piperidine 9o showed potent human and mouse NaV1.7 inhibitory activities with fai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40169ed87884e3ea4df0259263600814
https://pubmed.ncbi.nlm.nih.gov/26358159
https://pubmed.ncbi.nlm.nih.gov/26358159