Výsledky vyhledávání

A radioprotective agonist for p53 transactivation

Publikováno v: Molecular Cancer Therapeutics. 17(2):432-442

Inhibiting p53-dependent apoptosis by inhibitors of p53 is an effective strategy for preventing radiation-induced damage in hematopoietic lineages, while p53 and p21 also play radioprotective roles in the gastrointestinal epithelium. We previously id

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c357b9cc7ae5712599e289fb583f7c07
https://repo.lib.tokushima-u.ac.jp/111999

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Pranlukast reduces asthma exacerbations during autumn especially in 1- to 5-year-old boys

Autor: Midori Shigeta, Hiroyuki Kojima, Akiko Sawa, Akira Hoshioka, Hiroki Abe, Shuichi Suzuki, Yoshinori Sato, Naoki Shimojo, Yoshio Nakayama, Fumiya Yamaide, Mana Haraki, K. Saito, Yoshinori Morita, Eduardo Jose Campos Alberto, Yoichi Kohno, Toshikazu Tsubaki

Publikováno v: Asia Pacific Allergy

Background Leukotriene receptor antagonists have been used to prevent virus-induced asthma exacerbations in autumn. Its efficacy, however, might differ with age and sex. Objective This study aimed to investigate whether pranlukast added to usual asth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2697335f67e32e86f118260bd2053fed
http://europepmc.org/articles/PMC5287065

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Akademický článek

Covid-19 trouble at work: A comparative qualitative analysis of disclosure, sickness absence and return-to-work in the UK, the USA, Australia and Japan

Autor: Kaveri Qureshi, Jane Alice Evered, Rie Toyomoto, Anna Urbanowicz, Akiko Sawada, Lorraine Smith, Rika Sakuma Sato, Tanvi Rai

Publikováno v: SSM: Qualitative Research in Health, Vol 4, Iss , Pp 100307- (2023)

This paper addresses working people's narrated experiences of managing covid-related sickness in relation to employment. Bringing together the sociology of chronic illness and disability, and of work and organisations, we contribute to understandings

Externí odkaz: https://doaj.org/article/5e0c5a38bf76482d8f7878d62e1bd16b

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Akademický článek

Navigating responsible bio-political citizenship: Cross-country comparison of stigma in Covid-19 illness narratives in Germany, Japan, the UK and the USA

Autor: Anna Dowrick, Rachel Grob, Akiko Sawada, Anne Thier, Christine Holmberg, Rika Sakuma Sato

Publikováno v: SSM: Qualitative Research in Health, Vol 4, Iss , Pp 100291- (2023)

This paper aims to further understanding of discourses of responsible bio-political citizenship during the first year of the Covid-19 pandemic. This was an interview-based qualitative study comparing experiences of 103 people who were ill with Covid

Externí odkaz: https://doaj.org/article/101d6e87195a4914adec6f831a0068a0

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Design and Synthesis of 8-Hydroxyquinoline-based Radioprotective Agents

Autor: Ariyasu, Shinya, Akiko, Sawa, Morita, Akinori, Hanaya, Kengo, Hoshi, Misato, Ippei, Takahashi, Shin, Aoki

Publikováno v: Bioorganic & Medicinal Chemistry. 22(15):3891-3905

In radiation therapy, adverse side effects are often induced due to the excessive cell death that occurs in radiosensitive normal cells. The radiation-induced cell death of normal cells is caused, at least in part, by apoptosis, which undergoes via a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=jairo_______::4de8b441f51e13dcea83fda3eda6bebd
https://repo.qst.go.jp/records/46820

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Design and synthesis of 8-hydroxyquinoline-based radioprotective agents

Autor: I. Takahashi, Shin Aoki, Akiko Sawa, Kengo Hanaya, Misato Hoshi, Bing Wang, Shinya Ariyasu, Akinori Morita

Publikováno v: Bioorganic & Medicinal Chemistry. 22:3891-3905

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a18ba68ac05d9b82fa3b65aa4849a8
https://doi.org/10.1016/j.bmc.2014.06.017

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Akademický článek

Seasonal responses and host uniqueness of gut microbiome of Japanese macaques in lowland Yakushima

Autor: Akiko Sawada, Takashi Hayakawa, Yosuke Kurihara, Wanyi Lee, Goro Hanya

Publikováno v: Animal Microbiome, Vol 4, Iss 1, Pp 1-11 (2022)

Abstract Background Changes in the gut microbial composition is an important response to cope with the seasonal fluctuations in the environment such as food availability. We examined the bacterial gut microbiome of the wild nonhuman primate, Japanese

Externí odkaz: https://doaj.org/article/a74962af52bc472bab85ffcff6de81ba

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AS-2, a novel inhibitor of p53-dependent apoptosis, prevents apoptotic mitochondrial dysfunction in a transcription-independent manner and protects mice from a lethal dose of ionizing radiation

Autor: Takayoshi Onoda, Bing Wang, Shotaro Togami, Shinya Ariyasu, Shin Aoki, Kaoru Tanaka, Toshiya Inaba, Akinori Morita, Akiko Sawa, Mitsuru Nenoi, I. Takahashi, Tetsuo Asanuma

Publikováno v: Biochemical and biophysical research communications. 450(4)

In a previous study, we reported that some tetradentate zinc(II) chelators inhibit p53 through the denaturation of its zinc-requiring structure but a chelator, Bispicen, a potent inhibitor of in vitro apoptosis, failed to show any efficient radioprot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ebb2ad4b6066b1fd136a7cbb3b28b76
https://pubmed.ncbi.nlm.nih.gov/25026551

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