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Clinico-Pathological and Biological Significance of Tyrosine Kinase Domain Gene Mutations and Overexpression of Epidermal Growth Factor Receptor for Lung Adenocarcinoma

Autor: Yoshihiko Koshiishi, Kouki Ohtsuka, Akiko Ooide, Takashi Watanabe, Tomoyuki Goya, Go Furuyashiki, Satsuki Matsushima, Hiroaki Ohnishi, Hiroshi Nogami

Publikováno v: Journal of Thoracic Oncology. 1:787-795

Introduction Mutations in the tyrosine kinase domain (TKD) of the epidermal growth factor receptor ( EGFR ) gene have proven to be clinically significant in non-small cell lung cancer. However, relationships between these mutations and EGFR expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::759626843761149654120c9129de13aa
https://doi.org/10.1016/s1556-0864(15)30407-x

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A Simple and Sensitive Method for Detecting Major Mutations Within the Tyrosine Kinase Domain of the Epidermal Growth Factor Receptor Gene in Non???small-cell Lung Carcinoma

Autor: Tomoyuki Goya, Kouki Ohtsuka, Takashi Watanabe, Hiroaki Ohnishi, Akiko Ooide, Satsuki Matsushima

Publikováno v: Diagnostic Molecular Pathology. 15:101-108

The detection of mutations in the epidermal growth factor receptor (EGFR) gene impacts therapeutic decision-making for non-small-cell lung carcinoma (NSCLC). Although direct sequencing has been most frequently used to detect EGFR mutations, this meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd20182809e21209e3960d5fc6161027
https://doi.org/10.1097/00019606-200606000-00007

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