Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Akiko Ohkawa"'
1
Malonylated glycerolipids from the glandular trichome exudate of Ceratotheca triloba
Autor: Takaomi Sakai, Yoshinori Fujimoto, Kiyoshi Ohyama, Akiko Ohkawa
Publikováno v: Chem. Biodiv.. 9(No. 8):1611-1617
Chemical investigation of the glandular trichome exudate from Ceratotheca triloba (Pedaliaceae) led to the identification of nine 1-O-acetyl-2-O-[(R)-3-acetyloxy-fatty acyl]-3-O-malonylglycerols. Among these, 1-O-acetyl-2-O-[(R)-3-acetyloxyicosanoyl]
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f79e340c769cd8ce779f1bcfb389dd2b
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100652548
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2
The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF
Autor: Akiko Ohkawa, Kyoko Minowa, Yasuhiro Abe, Shin-ichi Tsunoda, Tetsuya Nomura, Shinsaku Nakagawa, Haruhiko Kamada, Yohei Mukai, Tsunetaka Ohta, Yasuo Yoshioka, Yasuo Tsutsumi, Hiroko Shibata, Madoka Taniai
Publikováno v: Biomaterials. 30:6638-6647
Blocking the binding of TNF-alpha to TNF receptor subtype-1 (TNFR1) is an important strategy for the treatment of rheumatoid arthritis (RA). We recently succeeded in developing a TNFR1-selective antagonistic TNF mutant, R1antTNF. Here, we report the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a80d1fe84312a5b3f67deb427ff5951
https://doi.org/10.1016/j.biomaterials.2009.08.041
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4
Creation of Novel Cell-Penetrating Peptides for Intracellular Drug Delivery Using Systematic Phage Display Technology Originated from Tat Transduction Domain
Autor: Yasuo Tsutsumi, Maki Kawamura, Takayuki Okamoto, Yohei Mukai, Tadanori Mayumi, Hiroko Shibata, Masaki Sato, Yasuhiro Abe, Sunao Imai, Shin-ichi Tsunoda, Shinsaku Nakagawa, Haruhiko Kamada, Kazuya Nagano, Akiko Ohkawa, Tetsuya Nomura, Toshiki Sugita
Publikováno v: Biological and Pharmaceutical Bulletin. 30:218-223
Many biologically active proteins need to be delivered intracellularly to exert their therapeutic action inside the cytoplasm. Cell penetrating peptides (CPPs) have been developed to efficiently deliver a wide variety of cargo in a fully biological a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4bc1c2037eef1f6068892ab881f1ac
https://doi.org/10.1248/bpb.30.218
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5
The therapeutic effect of TNFR1-selective antagonistic mutant TNF-alpha in murine hepatitis models
Autor: Shin-ichi Tsunoda, Yasuhiro Abe, Hiroko Shibata, Tetsuya Nomura, Shinsaku Nakagawa, Yohei Mukai, Haruhiko Kamada, Yasuo Yoshioka, Tsunetaka Ohta, Yasuo Tsutsumi, Madoka Taniai, Tadanori Mayumi, Akiko Ohkawa
Publikováno v: Cytokine. 44(2)
Tumor necrosis factor-alpha (TNF-alpha) is critically involved in a wide variety of inflammatory pathologies, such as hepatitis, via the TNF receptor-1 (TNFR1). To develop TNFR1-targeted anti-inflammatory drugs, we have already succeeded in creating
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f581970f0ad425a8b6516ce75763f57
https://pubmed.ncbi.nlm.nih.gov/18815054
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6
Changes in radiosensitivity of the in vitro fertilized mouse ova durin zygotic stage from fertilization to first cleavage
Autor: Osami Yukawa, Yoichi Matsuda, Takeshi Yamada, Akiko Ohkawa
Publikováno v: Journal of Radiation Research. 23:450-456
The radiosensitivity of mouse zygotes fertilized in vitro (BC3F1 ovum x ICR sperm) to X-rays has been measured as a function of time from fertilization to first cleavage. The dose of X-rays (LD50) required to prevent development of 50% of the zygotes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e79dfad3ead425bf734a02c9e2666c
https://doi.org/10.1269/jrr.23.450
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7
Distinction of G0 cells from senescent cells in cultures of non-cycling human fetal lung fibroblasts by anti-MAP-1 monoclonal antibody staining
Autor: Akiko Ohkawa, Chikako Sato, Tadao Ohno, Rie Kako
Publikováno v: Experimental Cell Research. 163:309-316
On staining with a monoclonal antibody raised against microtubule-associated protein-1 (MAP-1), dot-like structures were seen in the nuclei of interphase cells, but not in those of non-cycling G0-arrested cells. Dots were also not seen in the nuclei
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff8f2ab6c175767fbc85ca7717d7e12
https://doi.org/10.1016/0014-4827(86)90062-5
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8
Preliminary study on chromosomal aberrations in eggs of mice fertilized in vitro after X-irradiation
Autor: Akiko Ohkawa, Yoichi Matsuda, Izuo Tobari, Takeshi Yamada
Publikováno v: Mutation research. 121(2)
The X-ray induction of chromosomal aberrations in the eggs of mice fertilized in vitro was studied by using a fertilization technique developed by Yamada et al. (1982a,b). Mature sperm, eggs just before insemination and zygotes at the early pronuclea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c75620b8ad35090cdc6f06e7385e682f
https://pubmed.ncbi.nlm.nih.gov/6877270
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9
Factors controlling the appearance of the immunofluorescent nuclear dots revealed with monoclonal antibody against microtubule-associated protein-1
Autor: Akiko Ohkawa, T. Ohno, C. Sato
Publikováno v: Experimental cell research. 158(2)
A monoclonal antibody raised against microtubule-associated protein-1 (MAP-1) binds to nuclei of normal human fibroblasts, its binding site being detected as intranuclear immunofluorescent dots. The percentage of cells showing these dots increased wi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c478e1089bb55b23c91eb33139d1e4be
https://pubmed.ncbi.nlm.nih.gov/3891390
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10
Radiation-induced formation of apoptotic bodies in rat thymus
Autor: Harumi Ohyama, Takeshi Yamada, Ikuo Watanabe, Akiko Ohkawa
Publikováno v: Radiation research. 101(1)
The process of interphase death of thymocytes in whole-body X-irradiated rats were studied. Cell size distribution analysis indicates that cell fragments (= apoptotic bodies) appeared in the thymus and increased in number depending on dose (200-1000
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92a9eaecec028e491c2cf89bf1e7e71f
https://pubmed.ncbi.nlm.nih.gov/3881784
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