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Correlation of plasma concentration and adverse effects of bosutinib: standard dose or dose-escalation regimens of bosutinib treatment for patients with chronic myeloid leukemia

Autor: Akiko Mita, Maiko Abumiya, Masatomo Miura, Takenori Niioka, Saori Takahashi, Tomoko Yoshioka, Yoshihiro Kameoka, Naoto Takahashi

Publikováno v: Experimental Hematology & Oncology, Vol 7, Iss 1, Pp 1-8 (2018)

Abstract Purpose To investigate the exposure-toxicity relationship of bosutinib and to identify the target trough plasma concentration (C0). Methods The toxicity and C0 of bosutinib in Japanese chronic myeloid leukemia (CML) patients were monitored e

Externí odkaz: https://doaj.org/article/63174987a30d4d5abe4393225503964d

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Quantitative Real-Time RT-PCR Systems to Detect SARS-CoV-2

Autor: Sumino, Yanase, Hiroyoshi, Sasahara, Momoko, Nabetani, Kensuke, Yamazawa, Keisuke, Aoyagi, Akiko, Mita, Yuichi, Honma, Yasuhiko, Chiba

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2511

Since the outbreak of coronavirus disease 2019 (COVID-19) on the Diamond Princess cruise ship docked at Yokohama Port on February 3, 2020, real-time reverse transcription-polymerase chain reaction (RT-PCR) testing using nasopharyngeal swab samples fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::99e2a1bb75621c5b6b91618c0a24688e
https://pubmed.ncbi.nlm.nih.gov/35838954

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A Novel Real-Time PCR-Based Screening Test with Pooled Fecal Samples for Bovine Johne’s Disease

Autor: Yasuyuki Mori, Reiko Nagata, Yasutaka Minegishi, Shingo Kishizuka, Satoko Kawaji, Akiko Mita, Yumi Saruyama, Masahiro Saito

Publikováno v: J Clin Microbiol

Johne’s disease (JD) is an economically important infectious disease in livestock farming caused by Mycobacterium avium subsp. paratuberculosis. As an alternative to serological tests, which are used mainly for the screening of whole herds, we deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05de3593d47b97710ec60f8abe81c5dc
https://doi.org/10.1128/jcm.01761-20

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Correlation of plasma concentration and adverse effects of bosutinib: standard dose or dose-escalation regimens of bosutinib treatment for patients with chronic myeloid leukemia

Autor: Maiko Abumiya, Masatomo Miura, Yoshihiro Kameoka, Saori Takahashi, Akiko Mita, Tomoko Yoshioka, Takenori Niioka, Naoto Takahashi

Publikováno v: Experimental Hematology & Oncology
Experimental Hematology & Oncology, Vol 7, Iss 1, Pp 1-8 (2018)

Purpose To investigate the exposure-toxicity relationship of bosutinib and to identify the target trough plasma concentration (C0). Methods The toxicity and C0 of bosutinib in Japanese chronic myeloid leukemia (CML) patients were monitored every 2 we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1a1f56824d31ffc162dbbffc30f19a
https://doi.org/10.1186/s40164-018-0101-1

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Effects of polymorphisms in NR1I2, CYP3A4, and ABC transporters on the steady-state plasma trough concentrations of bosutinib in Japanese patient with chronic myeloid leukemia

Autor: Saori Takahashi, Maiko Abumiya, Tomoko Yoshioka, Masatomo Miura, Yoshihiro Kameoka, Akiko Mita, Naoto Takahashi

Publikováno v: Medical oncology (Northwood, London, England). 35(6)

We investigated the effects of polymorphisms in NR1I2 (7635A>G, 8055C>T), CYP3A4 (20230G>A), ABCB1 (1199G>A, 1236C>T, 2677G>T/A, 3435C>T), and ABCG2 (421C>A) on the mean plasma trough concentrations (C0) of bosutinib at the steady-state in 30 Japanes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d7ff17b6adc567ba19423b62b4698e
https://pubmed.ncbi.nlm.nih.gov/29736778

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Comparison of fecal pooling methods and DNA extraction kits for the detection of Mycobacterium avium subspecies paratuberculosis

Autor: Tomoko Tasaki, Yasuyuki Mori, Katsuo Utiyama, Akiko Mita, Hitomi Mori, Tetsuo Nakagawa

Publikováno v: MicrobiologyOpen

The aim of the study was to develop a sensitive method using quantitative real‐time polymerase chain reaction (qPCR) with pooled fecal samples for the screening of Johne's disease (JD). Manufacturer‐specified and our new pooling method in combina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce80105f2a31b5d11afab53dfc54d72
https://doi.org/10.1002/mbo3.318

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Pharmacokinetic and Pharmacogenetic Analysis of Bosutinib in Japanese Patients with Chronic-Phase Chronic Myeloid Leukemia

Autor: Maiko Abumiya, Akiko Mita, Naoto Takahashi, Saori Takahashi, Masatomo Miura, Yoshihiro Kameoka

Publikováno v: Blood. 132:4271-4271

Bosutinib is a second-generation Abl tyrosine kinase inhibitor (TKI) that was developed for the treatment of patients with Philadelphia chromosome-positive chronic myeloid leukemia (CML). Mainly metabolized by cytochrome P450 (CYP) 3A4, this TKI is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::feb822bc91f267de25aead9acac24c3c
https://doi.org/10.1182/blood-2018-99-111905

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