Výsledky vyhledávání - "Akiko Maruko-Otake"

Akademický článek

Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity.

Autor: Kanae Ando, Akiko Maruko-Otake, Yosuke Ohtake, Motoki Hayashishita, Michiko Sekiya, Koichi M Iijima

Publikováno v: PLoS Genetics, Vol 12, Iss 3, p e1005917 (2016)

Abnormal accumulation of the microtubule-interacting protein tau is associated with neurodegenerative diseases including Alzheimer's disease (AD). β-amyloid (Aβ) lies upstream of abnormal tau behavior, including detachment from microtubules, phosph

Externí odkaz: https://doaj.org/article/18e3fc9c09d0432693cd26eb85b17eaa

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Akademický článek

Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1.

Autor: Kanae Iijima-Ando, Michiko Sekiya, Akiko Maruko-Otake, Yosuke Ohtake, Emiko Suzuki, Bingwei Lu, Koichi M Iijima

Publikováno v: PLoS Genetics, Vol 8, Iss 8, p e1002918 (2012)

Abnormal phosphorylation and toxicity of a microtubule-associated protein tau are involved in the pathogenesis of Alzheimer's disease (AD); however, what pathological conditions trigger tau abnormality in AD is not fully understood. A reduction in th

Externí odkaz: https://doaj.org/article/f4160c4cb2804153b144060302028448

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Ca2+/calmodulin-dependent protein kinase II promotes neurodegeneration caused by tau phosphorylated at Ser262/356 in a transgenic Drosophila model of tauopathy

Autor: Yosuke Ohtake, Taro Saito, Sawako Shimizu, Kanae Ando, Naoki Fujisaki, Shin-ichi Hisanaga, Koichi M. Iijima, Mikiko Oka, Akiko Maruko-Otake

Publikováno v: The Journal of Biochemistry. 162:335-342

Abnormal deposition of the microtubule-associated protein tau is a common pathological feature of multiple neurodegenerative diseases, including Alzheimer's disease (AD), and plays critical roles in their pathogenesis. Disruption of calcium homeostas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7a02d2dd5875123b203c89e1b931b3
https://doi.org/10.1093/jb/mvx038

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Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity

Autor: Kanae Ando, Yosuke Ohtake, Motoki Hayashishita, Akiko Maruko-Otake, Michiko Sekiya, Koichi M. Iijima

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 12, Iss 3, p e1005917 (2016)

Abnormal accumulation of the microtubule-interacting protein tau is associated with neurodegenerative diseases including Alzheimer’s disease (AD). β-amyloid (Aβ) lies upstream of abnormal tau behavior, including detachment from microtubules, phos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2290e46f1aa152c7540cb6c97702560a
https://pubmed.ncbi.nlm.nih.gov/27023670

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EDEM Function in ERAD Protects against Chronic ER Proteinopathy and Age-Related Physiological Decline in Drosophila

Autor: Emiko Suzuki, Kanae Ando, Stephen Hearn, Koichi M. Iijima, Michiko Sekiya, Yasufumi Sakakibara, Naoki Fujisaki, Akiko Maruko-Otake

Publikováno v: Developmental Cell. 41:652-664.e5

The unfolded protein response (UPR), which protects cells against accumulation of misfolded proteins in the endoplasmic reticulum (ER), is induced in several age-associated degenerative diseases. However, sustained UPR activation has negative effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfdf254e7267c6cbab873f55e5166889
https://doi.org/10.1016/j.devcel.2017.05.019

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Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1

Autor: Emiko Suzuki, Kanae Iijima-Ando, Michiko Sekiya, Akiko Maruko-Otake, Yosuke Ohtake, Koichi M. Iijima, Bingwei Lu

Publikováno v: PLoS Genetics, Vol 8, Iss 8, p e1002918 (2012)
PLoS Genetics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa0083208bff06bea3c9d4aed51bc94e
http://europepmc.org/articles/PMC3431335?pdf=render

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