Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Akiko Kume"'
Autor:
Yuko Kokubu, Tomoko Nagino, Katsunori Sasa, Tatsuo Oikawa, Katsuya Miyake, Akiko Kume, Mikiko Fukuda, Hiromitsu Fuse, Ryuichi Tozawa, Hidetoshi Sakurai
Publikováno v:
Stem Cells Translational Medicine, Vol 8, Iss 10, Pp 1017-1029 (2019)
Abstract Dysferlinopathy is a progressive muscle disorder that includes limb‐girdle muscular dystrophy type 2B and Miyoshi myopathy (MM). It is caused by mutations in the dysferlin (DYSF) gene, whose function is to reseal the muscular membrane. Tre
Externí odkaz:
https://doaj.org/article/b07e2c3175334def8fbba6cc177a30d7
Publikováno v:
2022 7th International STEM Education Conference (iSTEM-Ed).
Publikováno v:
2022 7th International STEM Education Conference (iSTEM-Ed).
Autor:
Akiko Kume, Tomoko Nagino, Katsunori Sasa, Hidetoshi Sakurai, Katsuya Miyake, Mikiko Fukuda, Ryuichi Tozawa, Tatsuo Oikawa, Yuko Kokubu, Hiromitsu Fuse
Publikováno v:
Stem Cells Translational Medicine, Vol 8, Iss 10, Pp 1017-1029 (2019)
Stem Cells Translational Medicine
Stem Cells Translational Medicine
Dysferlinopathy is a progressive muscle disorder that includes limb-girdle muscular dystrophy type 2B and Miyoshi myopathy (MM). It is caused by mutations in the dysferlin (DYSF) gene, whose function is to reseal the muscular membrane. Treatment with
Publikováno v:
Journal of Bioscience and Bioengineering. 123:230-238
To investigate the binding properties of a peptide sequence, we conducted principal component analysis (PCA) of the physicochemical features of a tetramer peptide library comprised of 512 peptides, and the variables were reduced to two principal comp
Development of a tactical screening method to investigate the characteristics of functional peptides
Publikováno v:
Biotechnology and Bioprocess Engineering. 21:119-127
Using spot-synthesized peptide arrays, a functional peptide can be screened as a high-binding peptide for a target molecule. We have developed a rational screening method for functional peptides by analyzing the physicochemical rules of high-binding
Autor:
Akiko Kume, Takashi Sugino, Tadashi Ashizawa, Koichi Mitsuya, Ken Yamaguchi, Haruo Miyata, Maho Omiya, Akira Iizuka, Yasuto Akiyama, Yoko Nakasu, Chie Oshita, Masaru Komiyama, Nakamasa Hayashi
Publikováno v:
Oncology Reports. 32:159-166
The frequent recurrence of glioblastoma multiforme (GBM) after standard treatment with temozolomide (TMZ) is a crucial issue to be solved in the clinical field. O6‑methylguanine‑DNA methyltransferase (MGMT) is considered one of the major mechanis
Autor:
Chie Oshita, Akiko Kume, Masaru Komiyama, Ken Yamaguchi, Koichi Mitsuya, Tadashi Ashizawa, Yoko Nakasu, Yasuto Akiyama, Akira Iizuka, Nakamasa Hayashi
Publikováno v:
Immunology Letters. 159:15-22
Antibody direct cloning from single B cells is simple and efficient and has been successful in antibody identification of infectious diseases. However, although a recent whole-exome sequencing revealed abundant heterogeneic mutation accumulation in c
Autor:
Koichi Mitsuya, Haruo Miyata, Chie Oshita, Masahiro Nogami, Nakamasa Hayashi, Akira Iizuka, Yoko Nakasu, Reiko Watanabe, Yasuto Akiyama, Ken Yamaguchi, Mika Yagoto, Ichiro Ito, Akiko Kume, Tadashi Ashizawa, Masaru Komiyama, Takashi Sugino
Publikováno v:
Oncology Reports. 31:1683-1690
Glioblastoma multiforme (GBM) is one of the most malignant and aggressive tumors, and has a very poor prognosis with a mean survival time of2 years, despite intensive treatment using chemo-radiation. Therefore, novel therapeutic approaches including
Autor:
Toshio Furuya, Akira Asai, Masami Otsuka, Masaru Komiyama, Mika Yagoto, Haruo Miyata, Koichi Mitsuya, Ken Yamaguchi, Yoko Nakasu, Chie Oshita, Kenji Matsuno, Akiko Kume, Tadashi Okawara, Akira Iizuka, Yasuto Akiyama, Reiko Watanabe, Takuma Oishi, Masahiro Nogami, Naohisa Ogo, Ichiro Ito, Tadashi Ashizawa
Publikováno v:
International Journal of Oncology. 43:219-227
Signal transducer and activator of transcription (STAT) 3, a member of a family of DNA-binding molecules, is a potential target in the treatment of cancer. The highly phosphorylated STAT3 in cancer cells contributes to numerous physiological and onco